6EJX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ejx by Molmil](/molmil-images/mine/6ejx) | |
6EK7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ek7 by Molmil](/molmil-images/mine/6ek7) | YaxA from Yersinia enterocolitica | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, YaxA | 著者 | Braeuning, B, Groll, M. | 登録日 | 2017-09-25 | 公開日 | 2018-05-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure and mechanism of the two-component alpha-helical pore-forming toxin YaxAB. Nat Commun, 9, 2018
|
|
4WIJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wij by Molmil](/molmil-images/mine/4wij) | HUMAN SPLICING FACTOR, CONSTRUCT 1 | 分子名称: | Splicing factor, proline- and glutamine-rich | 著者 | lee, M, bond, c.s. | 登録日 | 2014-09-26 | 公開日 | 2015-04-01 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation. Nucleic Acids Res., 43, 2015
|
|
6EKN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ekn by Molmil](/molmil-images/mine/6ekn) | Crystal structure of MMP12 in complex with inhibitor BE7. | 分子名称: | (2~{S})-2-[2-[4-(4-methoxyphenyl)phenyl]sulfonylphenyl]pentanedioic acid, 1,2-ETHANEDIOL, CALCIUM ION, ... | 著者 | Ciccone, L, Tepshi, L, Nuti, E, Rossello, A, Stura, E.A. | 登録日 | 2017-09-26 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies. J. Med. Chem., 61, 2018
|
|
7YP1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yp1 by Molmil](/molmil-images/mine/7yp1) | Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 10E4 (localized refinement) | 分子名称: | 10E4 heavy chain, 10E4 light chain, EBV gH, ... | 著者 | Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N. | 登録日 | 2022-08-02 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection. Cell Rep Med, 4, 2023
|
|
6ENT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ent by Molmil](/molmil-images/mine/6ent) | Structure of the rat RKIP variant delta143-146 | 分子名称: | CHLORIDE ION, Phosphatidylethanolamine-binding protein 1, ZINC ION | 著者 | Koelmel, W, Hirschbeck, M, Schindelin, H, Lorenz, K, Kisker, C. | 登録日 | 2017-10-06 | 公開日 | 2017-12-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
6EL5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6el5 by Molmil](/molmil-images/mine/6el5) | Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation | 分子名称: | 8-(2-CHLORO-3,4,5-TRIMETHOXY-BENZYL)-2-FLUORO-9-PENT-4-YLNYL-9H-PURIN-6-YLAMINE, Heat shock protein HSP 90-alpha | 著者 | Musil, D, Lehmann, M, Eggenweiler, H.-M. | 登録日 | 2017-09-27 | 公開日 | 2018-05-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Estimation of Drug-Target Residence Times by tau-Random Acceleration Molecular Dynamics Simulations. J Chem Theory Comput, 14, 2018
|
|
7YOY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yoy by Molmil](/molmil-images/mine/7yoy) | Cryo-EM structure of EBV gHgL-gp42 in complex with mAbs 3E8 and 5E3 (localized refinement) | 分子名称: | 3E8 heavy chain, 3E8 light chain, 5E3 heavy chain, ... | 著者 | Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N. | 登録日 | 2022-08-02 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection. Cell Rep Med, 4, 2023
|
|
7YQ8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yq8 by Molmil](/molmil-images/mine/7yq8) | Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, 50-mer DNA, DNA topoisomerase 2-beta, ... | 著者 | Naganuma, M, Ehara, H, Kim, D, Nakagawa, R, Cong, A, Bu, H, Jeong, J, Jang, J, Schellenberg, M.J, Bunch, H, Sekine, S. | 登録日 | 2022-08-05 | 公開日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes. Nat Commun, 14, 2023
|
|
7YP2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yp2 by Molmil](/molmil-images/mine/7yp2) | Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 6H2 (localized refinement) | 分子名称: | 6H2 heavy chain, 6H2 light chain, Envelope glycoprotein H | 著者 | Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N. | 登録日 | 2022-08-02 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection. Cell Rep Med, 4, 2023
|
|
6EP3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ep3 by Molmil](/molmil-images/mine/6ep3) | Lar controls the expression of the Listeria monocytogenes agr system and mediates virulence. | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Lmo0651 protein, ... | 著者 | Pinheiro, J, Lisboa, J, Carvalho, F, Carreaux, A, Santos, N, Cabral, J, Sousa, S, Cabanes, D. | 登録日 | 2017-10-10 | 公開日 | 2018-07-25 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence. Nucleic Acids Res., 46, 2018
|
|
4WL3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wl3 by Molmil](/molmil-images/mine/4wl3) | |
4WLN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wln by Molmil](/molmil-images/mine/4wln) | |
6EPB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6epb by Molmil](/molmil-images/mine/6epb) | Structure of Chitinase 42 from Trichoderma harzianum | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Endochitinase 42, ... | 著者 | Ramirez-Escudero, M, Jimenez-Ortega, E, Sanz-Aparicio, J. | 登録日 | 2017-10-11 | 公開日 | 2018-09-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Use of chitin and chitosan to produce new chitooligosaccharides by chitinase Chit42: enzymatic activity and structural basis of protein specificity. Microb. Cell Fact., 17, 2018
|
|
7YOC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yoc by Molmil](/molmil-images/mine/7yoc) | |
4WML
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wml by Molmil](/molmil-images/mine/4wml) | Crystal structure of Saccharomyces cerevisiae OMP synthase in complex with PRP(CH2)P | 分子名称: | 1-O-[(R)-hydroxy(phosphonomethyl)phosphoryl]-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, Orotate phosphoribosyltransferase 1 | 著者 | Bang, M.B, Molich, U, Hansen, M.R, Grubmeyer, C, Harris, P. | 登録日 | 2014-10-09 | 公開日 | 2015-12-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Crystal structure of Saccharomyces cerevisia OMP synthase in complex with PRP(CH2)P To Be Published
|
|
6EPH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eph by Molmil](/molmil-images/mine/6eph) | Structure of the epsilon_1 / zeta_1 antitoxin toxin system from Neisseria gonorrhoeae in complex with UNAM. | 分子名称: | (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid, CITRATE ANION, Epsilon_1 antitoxin, ... | 著者 | Rocker, A, Meinhart, A. | 登録日 | 2017-10-11 | 公開日 | 2018-05-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The ng_ zeta 1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis. Nat Commun, 9, 2018
|
|
6ENP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6enp by Molmil](/molmil-images/mine/6enp) | Atomic resolution structure of human RNase 6 in the presence of phosphate anions in P21 space group. | 分子名称: | CHLORIDE ION, PHOSPHATE ION, Ribonuclease K6, ... | 著者 | Prats-Ejarque, G, Moussaoui, M, Boix, E. | 登録日 | 2017-10-05 | 公開日 | 2018-10-24 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.042 Å) | 主引用文献 | Characterization of an RNase with two catalytic centers. Human RNase6 catalytic and phosphate-binding site arrangement favors the endonuclease cleavage of polymeric substrates. Biochim Biophys Acta Gen Subj, 1863, 2019
|
|
4WG1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wg1 by Molmil](/molmil-images/mine/4wg1) | Room temperature crystal structure of lysozyme determined by serial synchrotron crystallography (micro focused beam - crystFEL) | 分子名称: | CHLORIDE ION, Lysozyme C | 著者 | Coquelle, N, Brewster, A.S, Kapp, U, Shilova, A, Weimhausen, B, Sauter, N.K, Burghammer, M, Colletier, J.P. | 登録日 | 2014-09-17 | 公開日 | 2015-05-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Raster-scanning serial protein crystallography using micro- and nano-focused synchrotron beams. Acta Crystallogr.,Sect.D, 71, 2015
|
|
6EPR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6epr by Molmil](/molmil-images/mine/6epr) | The ATAD2 bromodomain in complex with compound UZH-DS15 | 分子名称: | (~{N}~{Z},2~{R})-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-3~{H}-1,3-thiazol-2-ylidene]-1-[2-[4,4-bis(fluoranyl)cyclohexyl]ethyl]piperazine-2-carboxamide, ATPase family AAA domain-containing protein 2, SULFATE ION | 著者 | Sledz, P, Caflisch, A. | 登録日 | 2017-10-12 | 公開日 | 2018-10-31 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | 主引用文献 | Hitting a moving target: simulation and crystallography study of ATAD2 bromodomain blockers To Be Published
|
|
6EPT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ept by Molmil](/molmil-images/mine/6ept) | The ATAD2 bromodomain in complex with compound 12 | 分子名称: | (2~{R})-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-1,3-thiazol-2-yl]piperazine-2-carboxamide, (2~{S})-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-1,3-thiazol-2-yl]piperazine-2-carboxamide, ATPase family AAA domain-containing protein 2, ... | 著者 | Sledz, P, Caflisch, A. | 登録日 | 2017-10-12 | 公開日 | 2018-10-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers. Acs Med.Chem.Lett., 11, 2020
|
|
6ENV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6env by Molmil](/molmil-images/mine/6env) | |
4WGF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wgf by Molmil](/molmil-images/mine/4wgf) | YcaC from Pseudomonas aeruginosa with hexane-2,5-diol and covalent acrylamide | 分子名称: | (2R,5R)-hexane-2,5-diol, CHLORIDE ION, PROPIONAMIDE, ... | 著者 | Groftehauge, M.K, Truan, D, Vasil, A, Denny, P.W, Vasil, M.L, Pohl, E. | 登録日 | 2014-09-18 | 公開日 | 2015-07-29 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.34020686 Å) | 主引用文献 | Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide Adduct. Int J Mol Sci, 16, 2015
|
|
6EO8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eo8 by Molmil](/molmil-images/mine/6eo8) | Crystal structure of thrombin in complex with a novel glucose-conjugated potent inhibitor | 分子名称: | DIMETHYL SULFOXIDE, Hirudin variant-2, N-(2-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methoxy}-6-[3-(beta-D-glucopyranosyloxy)propoxy]phenyl)-1-(propan-2-yl)piperidine-4-carboxamide, ... | 著者 | Belviso, B.D, Caliandro, R, Aresta, B.M, De Candia, M, Altomare, C.D. | 登録日 | 2017-10-09 | 公開日 | 2017-12-13 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | How a beta-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties. J. Med. Chem., 57, 2014
|
|
6ER0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6er0 by Molmil](/molmil-images/mine/6er0) | |