8OUQ
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![BU of 8ouq by Molmil](/molmil-images/mine/8ouq) | Clr-11 from Rattus norvegicus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C-type lectin domain family 2 member D11 | 著者 | Skalova, T, Blaha, J, Kalouskova, B, Skorepa, O, Vanek, O, Dohnalek, J. | 登録日 | 2023-04-24 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Clr-11 from Rattus norvegicus To Be Published
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6O63
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4WFC
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![BU of 4wfc by Molmil](/molmil-images/mine/4wfc) | Structure of the Rrp6-Rrp47 interaction | 分子名称: | Exosome complex exonuclease RRP6, Exosome complex protein LRP1, SULFATE ION | 著者 | Schuch, B, Conti, E. | 登録日 | 2014-09-14 | 公開日 | 2014-10-29 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase. Embo J., 33, 2014
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5I4V
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![BU of 5i4v by Molmil](/molmil-images/mine/5i4v) | Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists | 分子名称: | Oxysterols receptor LXR-beta,Nuclear receptor coactivator 2, Retinoic acid receptor RXR-beta,Nuclear receptor coactivator 2, {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol | 著者 | Chen, G, McKeever, B.M. | 登録日 | 2016-02-12 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist. J.Med.Chem., 59, 2016
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7N6P
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![BU of 7n6p by Molmil](/molmil-images/mine/7n6p) | Crystal structure of the anti-EBOV and SUDV monoclonal antibody 1C3 Fab | 分子名称: | 1C3 Fab heavy chain, 1C3 Fab light chain | 著者 | Milligan, J.C, Yu, X, Buck, T, Saphire, E.O. | 登録日 | 2021-06-08 | 公開日 | 2022-04-06 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses. Cell, 185, 2022
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8SWF
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![BU of 8swf by Molmil](/molmil-images/mine/8swf) | Cryo-EM structure of NLRP3 open octamer | 分子名称: | NACHT, LRR and PYD domains-containing protein 3 | 著者 | Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S. | 登録日 | 2023-05-18 | 公開日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Cryo-EM structures of NLRP3 reveal its self-activation mechanism Nat Commun, 2024
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5IF4
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![BU of 5if4 by Molmil](/molmil-images/mine/5if4) | Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) inhibitors using Structure-Based Design | 分子名称: | 4-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-6-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Zhao, B. | 登録日 | 2016-02-25 | 公開日 | 2017-01-18 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.392 Å) | 主引用文献 | Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors. FEBS Lett., 591, 2017
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5LAL
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![BU of 5lal by Molmil](/molmil-images/mine/5lal) | Structure of Arabidopsis dirigent protein AtDIR6 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dirigent protein 6, ... | 著者 | Gasper, R, Kolesinski, P, Terlecka, B, Effenberger, I, Schaller, A, Hofmann, E. | 登録日 | 2016-06-14 | 公開日 | 2016-11-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Dirigent Protein Mode of Action Revealed by the Crystal Structure of AtDIR6. Plant Physiol., 172, 2016
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6OFZ
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![BU of 6ofz by Molmil](/molmil-images/mine/6ofz) | Crystal structure of human WDR5 | 分子名称: | WD repeat-containing protein 5 | 著者 | Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. | 登録日 | 2019-04-01 | 公開日 | 2020-04-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
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4WSP
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![BU of 4wsp by Molmil](/molmil-images/mine/4wsp) | Racemic crystal structure of Rv1738 from Mycobacterium tuberculosis (Form-I) | 分子名称: | CHLORIDE ION, protein DL-Rv1738 | 著者 | Bunker, R.D, Mandal, K, Kent, S.B.H, Baker, E.N. | 登録日 | 2014-10-28 | 公開日 | 2015-03-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography. Proc.Natl.Acad.Sci.USA, 112, 2015
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6OIP
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![BU of 6oip by Molmil](/molmil-images/mine/6oip) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 34 | 分子名称: | 2-fluoro-3-methyl-N'-[(naphthalen-2-yl)sulfonyl]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-04-09 | 公開日 | 2019-07-03 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
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7AJP
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![BU of 7ajp by Molmil](/molmil-images/mine/7ajp) | Crystal Structure of Human Adenovirus 56 Fiber Knob | 分子名称: | 1,2-ETHANEDIOL, Fiber, GLYCEROL, ... | 著者 | Strebl, M, Mindler, K, Stehle, T. | 登録日 | 2020-09-29 | 公開日 | 2021-01-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.382018 Å) | 主引用文献 | Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46. Proc.Natl.Acad.Sci.USA, 118, 2021
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7ALI
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![BU of 7ali by Molmil](/molmil-images/mine/7ali) | Crystal structure of the main protease (3CLpro/Mpro) of SARS-CoV-2 at 1.65A resolution (spacegroup P2(1)). | 分子名称: | 3C-like proteinase | 著者 | Costanzi, E, Demitri, N, Giabbai, B, Heroux, A, Storici, P. | 登録日 | 2020-10-06 | 公開日 | 2020-12-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L. Int J Mol Sci, 22, 2021
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6Y2B
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![BU of 6y2b by Molmil](/molmil-images/mine/6y2b) | Crystal structure of HLA-B2709 complexed with the nona-peptide mQ | 分子名称: | Beta-2-microglobulin, GLYCEROL, Lymphocyte antigen HLA-B27, ... | 著者 | Loll, B, Rueckert, C, Ziegler, B.-U, Ziegler, A. | 登録日 | 2020-02-15 | 公開日 | 2020-12-23 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | A CENTRAL PEPTIDE RESIDUE CAN CONTROL
MHC POLYMORPHISM-DEPENDENT ANTIGEN PRESENTATION to be published
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4X5R
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![BU of 4x5r by Molmil](/molmil-images/mine/4x5r) | Crystal structure of FimH in complex with a squaryl-phenyl alpha-D-mannopyranoside derivative | 分子名称: | 2-chloro-4-{[2-(4-methylpiperazin-1-yl)-3,4-dioxocyclobut-1-en-1-yl]amino}phenyl alpha-D-mannopyranoside, Protein FimH, SULFATE ION | 著者 | Preston, R.C, Jakob, R.P, Fiege, B, Zihlmann, P, Rabbani, S, Schwardt, O, Jiang, X, Ernst, B, Maier, T. | 登録日 | 2014-12-05 | 公開日 | 2015-05-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. Chembiochem, 16, 2015
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7AXL
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![BU of 7axl by Molmil](/molmil-images/mine/7axl) | Crystal structure of the hPXR-LBD in complex with estradiol and heptachlor endo-epoxide | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ESTRADIOL, Nuclear receptor subfamily 1 group I member 2, ... | 著者 | Delfosse, V, Granell, M, Blanc, P, Bourguet, W. | 登録日 | 2020-11-09 | 公開日 | 2021-01-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
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6ENG
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![BU of 6eng by Molmil](/molmil-images/mine/6eng) | Crystal structure of the 43K ATPase domain of Escherichia coli gyrase B in complex with an aminocoumarin | 分子名称: | CHLORIDE ION, Coumermycin A1, DNA gyrase subunit B, ... | 著者 | Vanden Broeck, A, McEwen, A.G, Lamour, V. | 登録日 | 2017-10-04 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis for DNA Gyrase Interaction with Coumermycin A1. J.Med.Chem., 62, 2019
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4WIG
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![BU of 4wig by Molmil](/molmil-images/mine/4wig) | Crystal structure of E47D mutant cytidine deaminase from Mycobacterium tuberculosis (MtCDA E47D) | 分子名称: | Cytidine deaminase, ZINC ION | 著者 | Trivella, D.B.B, Sanchez-Quitian, A.Z, Basso, L.A, Santos, D.S. | 登録日 | 2014-09-25 | 公開日 | 2015-08-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.758 Å) | 主引用文献 | Functional and structural evidence for the catalytic role played by glutamate-47 residue in the mode of action of Mycobacterium tuberculosis cytidine deaminase Rsc Adv, 5, 2015
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7TE1
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8PA2
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7N5Q
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6YES
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4WRK
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1BC8
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![BU of 1bc8 by Molmil](/molmil-images/mine/1bc8) | STRUCTURES OF SAP-1 BOUND TO DNA SEQUENCES FROM THE E74 AND C-FOS PROMOTERS PROVIDE INSIGHTS INTO HOW ETS PROTEINS DISCRIMINATE BETWEEN RELATED DNA TARGETS | 分子名称: | DNA (5'-D(*AP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*GP*GP*AP*AP*GP*T)-3'), PROTEIN (SAP-1 ETS DOMAIN), ... | 著者 | Mo, Y, Vaessen, B, Johnston, K, Marmorstein, R. | 登録日 | 1998-05-05 | 公開日 | 1998-12-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins. Mol.Cell, 2, 1998
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8PA1
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