PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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5ZDZ	Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in Ca2+ 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (30-MER), ... 著者 Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. 登録日 2018-02-25 公開日 2018-04-25 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Cracking the DNA Code for V(D)J Recombination Mol. Cell, 70, 2018
5DYU	Crystal Structure of BAZ2B bromodomain in complex with fragment F39 分子名称: 1H-imidazol-5-ylmethanol, Bromodomain adjacent to zinc finger domain protein 2B 著者 Lolli, G, Caflisch, A. 登録日 2015-09-25 公開日 2016-03-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography. Acs Chem.Biol., 11, 2016
6B9M	Crystal structure of UHRF1 TTD domain in complex with the polybasic region 分子名称: E3 ubiquitin-protein ligase UHRF1 著者 Song, J, Tan, X. 登録日 2017-10-10 公開日 2018-02-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 An Intramolecular Interaction of UHRF1 Reveals Dual Control for Its Histone Association. Structure, 26, 2018
6BAA	Cryo-EM structure of the pancreatic beta-cell KATP channel bound to ATP and glibenclamide 分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... 著者 Martin, G.M, Yoshioka, C, Shyng, S.L. 登録日 2017-10-12 公開日 2017-11-01 最終更新日 2019-12-25 実験手法 ELECTRON MICROSCOPY (3.63 Å) 主引用文献 Anti-diabetic drug binding site in a mammalian KATPchannel revealed by Cryo-EM. Elife, 6, 2017
5ZE0	Hairpin Forming Complex, RAG1/2-Nicked(with Dideoxy) 12RSS/23RSS complex in Mg2+ 分子名称: 1,2-ETHANEDIOL, DNA (30-MER), DNA (39-MER), ... 著者 Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. 登録日 2018-02-25 公開日 2018-04-25 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Cracking the DNA Code for V(D)J Recombination Mol. Cell, 70, 2018
5A8L	Human eRF1 and the hCMV nascent peptide in the translation termination complex 分子名称: 28S RIBOSOMAL RNA, 60S RIBOSOMAL PROTEIN L12, 60S RIBOSOMAL PROTEIN L17, ... 著者 Matheisl, S, Berninghausen, O, Becker, T, Beckmann, R. 登録日 2015-07-16 公開日 2015-12-02 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structure of a Human Translation Termination Complex. Nucleic Acids Res., 43, 2015
6DJ4	Crystal Structure of Bacillus thuringiensis Cry1A.105 Tryptic Core 分子名称: Cry1A.105 著者 Rydel, T.J, Sturman, E.J, Lee, T.C. 登録日 2018-05-24 公開日 2018-09-12 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Safety of the Bacillus thuringiensis-derived Cry1A.105 protein: Evidence that domain exchange preserves mode of action and safety. Regul. Toxicol. Pharmacol., 99, 2018
4JWL	Complexe of ARNO Sec7 domain with the protein-protein interaction inhibitor N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at pH7.5 分子名称: Cytohesin-2, N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide 著者 Hoh, F, Rouhana, J. 登録日 2013-03-27 公開日 2013-10-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors J.Med.Chem., 56, 2013
6DCQ	Ectodomain of full length, wild type HIV-1 glycoprotein clone PC64M18C043 in complex with PGT151 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Rantalainen, K. 登録日 2018-05-08 公開日 2018-06-27 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design. Cell Rep, 23, 2018
6D7J	The Crystal Structure of Parabacteroides merdae Beta-Glucuronidase (GUS) with Glycerol in Active-Site 分子名称: Beta-Glucuronidase, GLYCEROL, POTASSIUM ION, ... 著者 Little, M.S, Redinbo, M.R. 登録日 2018-04-24 公開日 2019-05-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Active site flexibility revealed in crystal structures of Parabacteroides merdae beta-glucuronidase from the human gut microbiome. Protein Sci., 27, 2018
6C1V	MBD2 in complex with double-stranded DNA 分子名称: 12-mer DNA, Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION 著者 Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2018-01-05 公開日 2018-02-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. J. Biol. Chem., 293, 2018
6EL6	Glucocorticoid Receptor in complex with compound 4 分子名称: 1,2-ETHANEDIOL, Glucocorticoid receptor, Nuclear receptor coactivator 2, ... 著者 Edman, K, Wissler, L. 登録日 2017-09-28 公開日 2018-02-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J. Med. Chem., 61, 2018
6EOO	DPP8 - Apo, space group 20 分子名称: Dipeptidyl peptidase 8 著者 Ross, B.R, Huber, R. 登録日 2017-10-10 公開日 2018-02-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6ER3	Ruminococcus gnavus IT-sialidase CBM40 bound to alpha2,3 sialyllactose 分子名称: BNR/Asp-box repeat protein, GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose 著者 Owen, C.D, Tailford, L.E, Taylor, G.L, Juge, N. 登録日 2017-10-16 公開日 2018-05-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus. Nat Commun, 8, 2017
6ERQ	Structure of the human mitochondrial transcription initiation complex at the HSP promoter 分子名称: DNA-directed RNA polymerase, mitochondrial, Dimethyladenosine transferase 2, ... 著者 Hillen, H.S, Morozov, Y.I, Sarfallah, A, Temiakov, D, Cramer, P. 登録日 2017-10-18 公開日 2017-11-15 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Structural Basis of Mitochondrial Transcription Initiation. Cell, 171, 2017
6BRR	Crystal structure of DNMT3A (R836A)-DNMT3L in complex with DNA containing two CpG sites 分子名称: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... 著者 Zhang, Z.M, Song, J. 登録日 2017-11-30 公開日 2018-01-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554, 2018
4M6W	Crystal structure of the C-terminal segment of FANCM in complex with FAAP24 分子名称: Fanconi anemia group M protein, Fanconi anemia-associated protein of 24 kDa, SULFATE ION 著者 Yang, H, Zhang, T, Tong, L, Ding, J. 登録日 2013-08-11 公開日 2013-10-02 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair. Nucleic Acids Res., 41, 2013
6EC6	Ruminococcus gnavus Beta-glucuronidase 分子名称: Beta-glucuronidase, CHLORIDE ION, GLYCEROL 著者 Biernat, K.A, Redinbo, M.R. 登録日 2018-08-07 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep, 9, 2019
6C4G	Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-601) 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Czabotar, P.E, Hodder, A.N, Nguyen, W, Sleebs, B.E, Boddey, J.A, Cowman, A.F. 登録日 2018-01-11 公開日 2018-06-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2position of PEXEL peptidomimetics. Eur J Med Chem, 154, 2018
6DCG	Discovery of MK-8353: An Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology 分子名称: (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 Boga, S.B, Deng, Y, Zhu, L, Nan, Y, Cooper, A, Shipps Jr, G.W, Doll, R, Shih, N, Zhu, H, Sun, R, Wang, T, Paliwal, S, Tsui, H, Gao, X, Yao, X, Desai, J, Wang, J, Alhassan, A.B, Kelly, J, Patel, M, Muppalla, K, Gudipati, S, Zhang, L, Buevich, A, Hesk, D, Carr, D, Dayananth, P, Mei, H, Cox, K, Sherborne, B, Hruza, A.W, Xiao, L, Jin, W, Long, B, Liu, G, Taylor, S.A, Kirschmeier, P, Windsor, W.T, Bishop, R, Samatar, A.A. 登録日 2018-05-06 公開日 2018-08-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology. ACS Med Chem Lett, 9, 2018
5E73	Crystal Structure of BAZ2B bromodomain in complex with acetylindole compound UZH47 分子名称: Bromodomain adjacent to zinc finger domain protein 2B, N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)acetamide 著者 Lolli, G, Spiliotopoulos, D, Unzue, A, Nevado, C, Caflisch, A. 登録日 2015-10-11 公開日 2015-10-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains. J. Med. Chem., 59, 2016
5WU1	Crystal structure of apo human Tut1, form I 分子名称: CHLORIDE ION, Speckle targeted PIP5K1A-regulated poly(A) polymerase 著者 Yamashita, S, Tomita, K. 登録日 2016-12-16 公開日 2017-05-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structures of U6 snRNA-specific terminal uridylyltransferase Nat Commun, 8, 2017
6EL9	Glucocorticoid Receptor in complex with AZD9567 分子名称: 1,2-ETHANEDIOL, 2,2-bis(fluoranyl)-~{N}-[(1~{R},2~{S})-3-methyl-1-[1-(1-methyl-6-oxidanylidene-pyridin-3-yl)indazol-5-yl]oxy-1-phenyl-butan-2-yl]propanamide, Glucocorticoid receptor, ... 著者 Edman, K, Wissler, L. 登録日 2017-09-28 公開日 2018-02-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J. Med. Chem., 61, 2018
2OZA	Structure of p38alpha complex 分子名称: MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14 著者 White, A, Pargellis, C.A, Studts, J.M, Werneburg, B.G, Farmer II, B.T. 登録日 2007-02-25 公開日 2007-04-03 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular basis of MAPK-activated protein kinase 2:p38 assembly Proc.Natl.Acad.Sci.Usa, 104, 2007
6H0M	17beta-hydroxysteroid dehydrogenase type 14 mutant K158A in complex with Nicotinamide Adenine Dinucleotide 分子名称: 17-beta-hydroxysteroid dehydrogenase 14, DIMETHYL SULFOXIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Badran, M, Klebe, G, Heine, A, Marchais-Oberwinkler, S. 登録日 2018-07-10 公開日 2019-07-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 17beta-hydroxysteroid dehydrogenase type 14 mutant K158A in complex with Nicotinamide Adenine Dinucleotide To Be Published

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