6EL6

Glucocorticoid Receptor in complex with compound 4

Summary for 6EL6

DescriptorGlucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordsglucocorticoid receptor, nuclear hormone receptor, steroid receptor, ligand complex, peptide complex, signaling protein
Biological sourceHomo sapiens (Human)
Cellular locationIsoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus  P04150
Nucleus Q15596
Total number of polymer chains2
Total molecular weight34418.64
Authors
Edman, K.,Wissler, L. (deposition date: 2017-09-28, release date: 2018-02-21, Last modification date: 2018-03-21)
Primary citation
Ripa, L.,Edman, K.,Dearman, M.,Edenro, G.,Hendrickx, R.,Ullah, V.,Chang, H.F.,Lepisto, M.,Chapman, D.,Geschwindner, S.,Wissler, L.,Svanberg, P.,Lawitz, K.,Malmberg, J.,Nikitidis, A.,Olsson, R.I.,Bird, J.,Llinas, A.,Hegelund-Myrback, T.,Berger, M.,Thorne, P.,Harrison, R.,Kohler, C.,Drmota, T.
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J. Med. Chem., 61:1785-1799, 2018
PubMed: 29424542 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.7b01690
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.255201.7%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6el6
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Molmil generated image of 6el6
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Molmil generated image of 6el6
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