6EL6
Glucocorticoid Receptor in complex with compound 4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucocorticoid receptor | polymer | 280 | 32187.1 | 1 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 2 | B (B) | Nuclear receptor coactivator 2 | polymer | 14 | 1708.9 | 1 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | ~{N}-[(1~{R},2~{S})-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide | non-polymer | 460.5 | 1 | Chemie (B9Q) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A: 500 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 498 | - | expression tag |
| Ser 499 | - | expression tag |
| Asp 517 | Asn 517 | engineered mutation |
| Met 571 | Val 571 | engineered mutation |
| Ser 602 | Phe 602 | engineered mutation |
| Asp 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33896.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 522.6 | |
| All* | Total formula weight | 34418.6 |
