PDB: 1371 件ウェブページステータス検索Chemie searchBIRD

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6K3Q	Crystal Structure of P450BM3 with N-(3-cyclohexylpropanoyl)-L-prolyl-L-phenylalanine 分子名称: (2S)-2-[[(2S)-1-(3-cyclohexylpropanoyl)pyrrolidin-2-yl]carbonylamino]-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, DIMETHYL SULFOXIDE, ... 著者 Shoji, O, Yonemura, K. 登録日 2019-05-21 公開日 2020-05-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3 Acs Catalysis, 10, 2020
6LAA	Crystal structure of full-length CYP116B46 from Tepidiphilus thermophilus 分子名称: 1,2-ETHANEDIOL, CARBONATE ION, Cytochrome P450, ... 著者 Zhang, L.L, Ko, T.P, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. 登録日 2019-11-12 公開日 2020-06-10 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase. Nat Commun, 11, 2020
6L8I	Crystal structure of CYP97A3 mutant S290D/W300L/S304V 分子名称: PROTOPORPHYRIN IX CONTAINING FE, Protein LUTEIN DEFICIENT 5, chloroplastic 著者 Niu, G, Guo, Q, Liu, L. 登録日 2019-11-06 公開日 2020-06-10 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for plant lutein biosynthesis from alpha-carotene. Proc.Natl.Acad.Sci.USA, 117, 2020
6L8H	Crystal structure of CYP97C1 分子名称: Carotene epsilon-monooxygenase, chloroplastic, GLYCEROL, ... 著者 Niu, G, Guo, Q, Liu, L. 登録日 2019-11-06 公開日 2020-06-10 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for plant lutein biosynthesis from alpha-carotene. Proc.Natl.Acad.Sci.USA, 117, 2020
6L8J	Crystal structure of CYP97A3 mutant S290D/W300L/S304V in complex with retinal 分子名称: PROTOPORPHYRIN IX CONTAINING FE, Protein LUTEIN DEFICIENT 5, chloroplastic, ... 著者 Niu, G, Guo, Q, Liu, L. 登録日 2019-11-06 公開日 2020-06-10 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.399 Å) 主引用文献 Structural basis for plant lutein biosynthesis from alpha-carotene. Proc.Natl.Acad.Sci.USA, 117, 2020
6UEZ	Human sterol 14a-demethylase (CYP51) in complex with the substrate lanosterol 分子名称: LANOSTEROL, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE 著者 Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I. 登録日 2019-09-23 公開日 2020-06-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis. J.Biol.Chem., 295, 2020
6XZ8	Structure of aldosterone synthase (CYP11B2) in complex with N-[(1R)-1-[5-(6-chloro-1,1-dimethyl-3-oxo-isoindolin-2-yl)-3-pyridyl]ethyl]methanesulfonamide 分子名称: Cytochrome P450 11B2, mitochondrial, HEME C, ... 著者 Kuglstatter, A, Joseph, C, Benz, J. 登録日 2020-02-03 公開日 2020-06-24 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. J.Med.Chem., 63, 2020
6XZ9	Structure of aldosterone synthase (CYP11B2) in complex with 5-chloro-3,3-dimethyl-2-[5-[1-(1-methylpyrazole-4-carbonyl)azetidin-3-yl]oxy-3-pyridyl]isoindolin-1-one 分子名称: 5-chloranyl-3,3-dimethyl-2-[5-[1-(1-methylpyrazol-4-yl)carbonylazetidin-3-yl]oxypyridin-3-yl]isoindol-1-one, Cytochrome P450 11B2, mitochondrial, ... 著者 Kuglstatter, A, Joseph, C, Benz, J. 登録日 2020-02-03 公開日 2020-06-24 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. J.Med.Chem., 63, 2020
6WPL	Structure of Cytochrome P450tcu 分子名称: 5-EXO-HYDROXYCAMPHOR, Cytochrome P-450cam, subunit of camphor 5-monooxygenase system, ... 著者 Murarka, V.C, Batabyal, D, Amaya, J.A, Sevrioukova, I.F, Poulos, T.L. 登録日 2020-04-27 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.097 Å) 主引用文献 Unexpected Differences between Two Closely Related Bacterial P450 Camphor Monooxygenases. Biochemistry, 59, 2020
6KBH	Crystal structure of an intact type IV self-sufficient cytochrome P450 monooxygenase 分子名称: Cytochrome P450 monooxygenase, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... 著者 Gong, R, Wu, L.J, Zhang, Y, Liu, Z, Dou, S, Zhang, R.G, Xu, J.H, Tang, C, Zhou, J.H. 登録日 2019-06-25 公開日 2020-07-01 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of an intact type IV self-sufficient cytochrome P450 monooxygenase To Be Published
6WGW	CYP101D1 D259E Hydroxycamphor bound 分子名称: 5-EXO-HYDROXYCAMPHOR, CAMPHOR, Cytochrome P450 101D1, ... 著者 Amaya, J.A, Poulos, T.L, Batabyal, D. 登録日 2020-04-06 公開日 2020-07-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Proton Relay Network in the Bacterial P450s: CYP101A1 and CYP101D1. Biochemistry, 59, 2020
6WE6	Camphor bound P450cam D251E structure 分子名称: CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... 著者 Amaya, J.A, Poulos, T.L, Batabyal, D. 登録日 2020-04-01 公開日 2020-07-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Proton Relay Network in the Bacterial P450s: CYP101A1 and CYP101D1. Biochemistry, 59, 2020
6WFL	Camphor soaked P450cam D251E 分子名称: 5-EXO-HYDROXYCAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... 著者 Amaya, J.A, Poulos, T.L, Batabyal, D. 登録日 2020-04-03 公開日 2020-07-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Proton Relay Network in the Bacterial P450s: CYP101A1 and CYP101D1. Biochemistry, 59, 2020
6KFW	The cytochrome P450 enzyme CxnD for C-S bond formation in chuangxinmycin biosynthesis 分子名称: (2R)-3-(1H-indol-3-yl)-2-methylsulfanyl-propanoic acid, CxnD, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Hong, B. 登録日 2019-07-09 公開日 2020-07-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Cytochrome P450 Catalyzing C-S Bond Formation in S-Heterocyclization of Chuangxinmycin Biosynthesis. Angew.Chem.Int.Ed.Engl., 60, 2021
6M4P	Cytochrome P450 monooxygenase StvP2 substrate-bound structure 分子名称: 6-methoxy-streptovaricin C, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Sun, G, Hu, C, Mei, Q, Luo, M, Chen, X, Li, Z, Liu, Y, Deng, Z, Zhang, Z, Sun, Y. 登録日 2020-03-08 公開日 2020-08-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis. Nat Commun, 11, 2020
6M4Q	Cytochrome P450 monooxygenase StvP2 substrate-free structure 分子名称: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Sun, G, Hu, C, Mei, Q, Luo, M, Chen, X, Li, Z, Liu, Y, Deng, Z, Zhang, Z, Sun, Y. 登録日 2020-03-08 公開日 2020-08-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis. Nat Commun, 11, 2020
6U31	The crystal structure of 4-(1H-imidazol-1-yl)benzoate-bound CYP199A4 分子名称: 4-(1H-imidazol-1-yl)benzoic acid, CHLORIDE ION, Cytochrome P450, ... 著者 Podgorski, M.N, Bruning, J.B, Bell, S.G. 登録日 2019-08-21 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.578 Å) 主引用文献 To Be, or Not to Be, an Inhibitor: A Comparison of Azole Interactions with and Oxidation by a Cytochrome P450 Enzyme. Inorg.Chem., 61, 2022
6L3A	Cytochrome P450 107G1 (RapN) with everolimus 分子名称: Cytochrome P450, Everolimus, PROTOPORPHYRIN IX CONTAINING FE 著者 Km, V.C, Kim, D.H, Lim, Y.R, Lee, I.H, Lee, J.H, Kang, L.W. 登録日 2019-10-10 公開日 2020-09-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural insights into CYP107G1 from rapamycin-producing Streptomyces rapamycinicus. Arch.Biochem.Biophys., 692, 2020
6L39	Cytochrome P450 107G1 (RapN) 分子名称: Cytochrome P450, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ... 著者 Kim, V.C, Kim, D.H, Lim, Y.R, Lee, I.H, Lee, J.H, Kang, L.W. 登録日 2019-10-10 公開日 2020-09-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 Structural insights into CYP107G1 from rapamycin-producing Streptomyces rapamycinicus. Arch.Biochem.Biophys., 692, 2020
6UDL	Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2700 分子名称: Cytochrome P450 1A1, PROTOPORPHYRIN IX CONTAINING FE, [(1S)-1-(chloromethyl)-1,6-dihydropyrrolo[3,2-e]indol-3(2H)-yl](5-methoxy-1H-indol-2-yl)methanone 著者 Bart, A.G, Scott, E.E. 登録日 2019-09-19 公開日 2020-09-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Cytochrome P450 binding and bioactivation of tumor-targeted duocarmycin agents Drug Metab.Dispos., 2021
6KZS	Crystal structure of cytochrome P450mel 107F1 in complex with heme and imidazole 分子名称: Cytochrome P-450, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE 著者 Hou, X.D, Rao, Y.J, Icyishaka, P, Li, C.X, Lou, J.L. 登録日 2019-09-25 公開日 2020-09-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.601 Å) 主引用文献 Crystallization and X-ray analysis of cytochrome P450mel 107F1 with biaryl coupling reactivity To Be Published
6KZT	Crystal structure of cytochrome P450mel 107F1 with biaryl coupling reactivity 分子名称: Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE 著者 Hou, X.D, Rao, Y.J, Icyishaka, P, Li, C.X, Lou, J.L. 登録日 2019-09-25 公開日 2020-09-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Crystallization and X-ray analysis of cytochrome P450mel 107F1 with biaryl coupling reactivity To Be Published
6L69	Crystal structure of CYP154C2 from Streptomyces avermitilis 分子名称: Cytochrome P450 hydroxylase, PROTOPORPHYRIN IX CONTAINING FE 著者 Xu, L.H, Fushinobu, S. 登録日 2019-10-28 公開日 2020-09-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Regio- and stereoselective hydroxylation of testosterone by a novel cytochrome P450 154C2 from Streptomyces avermitilis. Biochem.Biophys.Res.Commun., 522, 2020
6UDM	Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2726 分子名称: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Cytochrome P450 1A1, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Bart, A.G, Scott, E.E. 登録日 2019-09-19 公開日 2020-09-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.075 Å) 主引用文献 Cytochrome P450 binding and bioactivation of tumor-targeted duocarmycin agents Drug Metab.Dispos., 2021
6L1A	Crystal Structure of P450BM3 with N-enanthoyl-L-prolyl-L-phenylalanine 分子名称: (2S)-2-[[(2S)-1-heptanoylpyrrolidin-2-yl]carbonylamino]-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, DIMETHYL SULFOXIDE, ... 著者 Shoji, O, Yonemura, K. 登録日 2019-09-28 公開日 2020-09-30 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3 Acs Catalysis, 10, 2020

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