6UDM

Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2726

Summary for 6UDM

• Entry DOI: 10.2210/pdb6udm/pdb
• Descriptor: Cytochrome P450 1A1, PROTOPORPHYRIN IX CONTAINING FE, [(8S)-8-(chloromethyl)-7,8-dihydro-6H-furo[3,2-e]indol-6-yl](5-fluoro-1H-indol-2-yl)methanone, ... (4 entities in total)
• Functional Keywords: cyp1a1, p450, oxidoreductase, duocarmycin
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 228332.61

Authors

Bart, A.G.,Scott, E.E. (deposition date: 2019-09-19, release date: 2020-09-23, Last modification date: 2023-10-11)

• Primary citation: Bart, A.G.,Morais, G.,Vangala, V.R.,Loadman, P.M.,Pors, K.,Scott, E.E.; Cytochrome P450 binding and bioactivation of tumor-targeted duocarmycin agents; Drug Metab.Dispos., 2021

Experimental method

X-RAY DIFFRACTION (3.075 Å)