6UDM
Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2726
Summary for 6UDM
Entry DOI | 10.2210/pdb6udm/pdb |
Descriptor | Cytochrome P450 1A1, PROTOPORPHYRIN IX CONTAINING FE, [(8S)-8-(chloromethyl)-7,8-dihydro-6H-furo[3,2-e]indol-6-yl](5-fluoro-1H-indol-2-yl)methanone, ... (4 entities in total) |
Functional Keywords | cyp1a1, p450, oxidoreductase, duocarmycin |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 228332.61 |
Authors | Bart, A.G.,Scott, E.E. (deposition date: 2019-09-19, release date: 2020-09-23, Last modification date: 2023-10-11) |
Primary citation | Bart, A.G.,Morais, G.,Vangala, V.R.,Loadman, P.M.,Pors, K.,Scott, E.E. Cytochrome P450 binding and bioactivation of tumor-targeted duocarmycin agents Drug Metab.Dispos., 2021 |
Experimental method | X-RAY DIFFRACTION (3.075 Å) |
Structure validation
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