6UDM
Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2726
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cytochrome P450 1A1 | polymer | 491 | 55944.2 | 4 | UniProt (P04798) Pfam (PF00067) | Homo sapiens (Human) | CYPIA1,Cytochrome P450 form 6,Cytochrome P450-C,Cytochrome P450-P1,Hydroperoxy icosatetraenoate dehydratase |
| 2 | E, H, J, L (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, I, K, M (A, B, C, D) | [(8S)-8-(chloromethyl)-7,8-dihydro-6H-furo[3,2-e]indol-6-yl](5-fluoro-1H-indol-2-yl)methanone | non-polymer | 368.8 | 4 | Chemie (Q4P) | |||
| 4 | G (A) | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 1 | Chemie (CPS) |
Sequence modifications
A, B, C, D: 35 - 512 (UniProt: P04798)
| PDB | External Database | Details |
|---|---|---|
| Met 28 | - | expression tag |
| Ala 29 | - | expression tag |
| Lys 30 | - | expression tag |
| Lys 31 | - | expression tag |
| Thr 32 | - | expression tag |
| Ser 33 | - | expression tag |
| Ser 34 | - | expression tag |
| His 513 | - | expression tag |
| His 514 | - | expression tag |
| His 515 | - | expression tag |
| His 516 | - | expression tag |
| His 517 | - | expression tag |
| His 518 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 223776.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 4556.0 | |
| All* | Total formula weight | 228332.6 |
