6UDM
Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2726
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Cytochrome P450 1A1 | polymer | 491 | 55944.2 | 4 | UniProt (P04798) Pfam (PF00067) In PDB | Homo sapiens (Human) | CYPIA1,Cytochrome P450 form 6,Cytochrome P450-C,Cytochrome P450-P1,Hydroperoxy icosatetraenoate dehydratase |
2 | A, B, C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
3 | A, B, C, D | [(8S)-8-(chloromethyl)-7,8-dihydro-6H-furo[3,2-e]indol-6-yl](5-fluoro-1H-indol-2-yl)methanone | non-polymer | 368.8 | 4 | Chemie (Q4P) | |||
4 | A | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 1 | Chemie (CPS) |
Sequence modifications
A, B, C, D: 35 - 512 (UniProt: P04798)
PDB | External Database | Details |
---|---|---|
Met 28 | - | expression tag |
Ala 29 | - | expression tag |
Lys 30 | - | expression tag |
Lys 31 | - | expression tag |
Thr 32 | - | expression tag |
Ser 33 | - | expression tag |
Ser 34 | - | expression tag |
His 513 | - | expression tag |
His 514 | - | expression tag |
His 515 | - | expression tag |
His 516 | - | expression tag |
His 517 | - | expression tag |
His 518 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 223776.6 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 4556.0 | |
All* | Total formula weight | 228332.6 |