6UEZ
Human sterol 14a-demethylase (CYP51) in complex with the substrate lanosterol
Summary for 6UEZ
Entry DOI | 10.2210/pdb6uez/pdb |
Descriptor | Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, LANOSTEROL, ... (4 entities in total) |
Functional Keywords | monooxygenase, sterol biosynthesis, cytochrome p450, substrate-induced conformational change, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 105699.47 |
Authors | Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (deposition date: 2019-09-23, release date: 2020-06-10, Last modification date: 2023-10-11) |
Primary citation | Hargrove, T.Y.,Wawrzak, Z.,Guengerich, F.P.,Lepesheva, G.I. A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis. J.Biol.Chem., 295:9998-10007, 2020 Cited by PubMed: 32493730DOI: 10.1074/jbc.RA120.014064 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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