6UEZ

Human sterol 14a-demethylase (CYP51) in complex with the substrate lanosterol

Summary for 6UEZ

Entry DOI	10.2210/pdb6uez/pdb
Descriptor	Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, LANOSTEROL, ... (4 entities in total)
Functional Keywords	monooxygenase, sterol biosynthesis, cytochrome p450, substrate-induced conformational change, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	105699.47
Authors	Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (deposition date: 2019-09-23, release date: 2020-06-10, Last modification date: 2023-10-11)
Primary citation	Hargrove, T.Y.,Wawrzak, Z.,Guengerich, F.P.,Lepesheva, G.I. A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis. J.Biol.Chem., 295:9998-10007, 2020 Cited by PubMed: 32493730 DOI: 10.1074/jbc.RA120.014064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation