6UEZ
Human sterol 14a-demethylase (CYP51) in complex with the substrate lanosterol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lanosterol 14-alpha demethylase | polymer | 454 | 51806.5 | 2 | UniProt (Q16850) Pfam (PF00067) | Homo sapiens (Human) | LDM, CYPLI, Cytochrome P450 51A1, Cytochrome P450-14DM, Cytochrome P45014DM, Cytochrome P450LI, Sterol 14-alpha demethylase |
| 2 | C, E (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, F (A, B) | LANOSTEROL | non-polymer | 426.7 | 2 | Chemie (LAN) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 514 | Chemie (HOH) |
Sequence modifications
A, B: 61 - 503 (UniProt: Q16850)
| PDB | External Database | Details |
|---|---|---|
| Met 50 | - | expression tag |
| Ala 51 | - | expression tag |
| Lys 52 | - | expression tag |
| Lys 53 | - | expression tag |
| Thr 54 | - | expression tag |
| Ser 55 | - | expression tag |
| Ser 56 | - | expression tag |
| Lys 57 | - | expression tag |
| Gly 58 | - | expression tag |
| Lys 59 | - | expression tag |
| Leu 60 | - | expression tag |
| Ala 231 | Asp 231 | engineered mutation |
| Ala 314 | His 314 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 103613.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2086.4 | |
| All* | Total formula weight | 105699.5 |
