6UEZ
Human sterol 14a-demethylase (CYP51) in complex with the substrate lanosterol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lanosterol 14-alpha demethylase | polymer | 454 | 51806.5 | 2 | UniProt (Q16850) Pfam (PF00067) | Homo sapiens (Human) | LDM, CYPLI, Cytochrome P450 51A1, Cytochrome P450-14DM, Cytochrome P45014DM, Cytochrome P450LI, Sterol 14-alpha demethylase |
| 2 | C, E (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, F (A, B) | LANOSTEROL | non-polymer | 426.7 | 2 | Chemie (LAN) PubChem (856) PubChem (101257) PubChem (122860) PubChem (246983) PubChem (441678) PubChem (472761) PubChem (1548892) PubChem (5317296) PubChem (6432724) PubChem (6708538) PubChem (6708649) PubChem (7060882) PubChem (11539168) PubChem (12121697) PubChem (12305456) PubChem (12305458) PubChem (16758112) PubChem (20849111) PubChem (21117583) PubChem (21145180) PubChem (22790277) PubChem (71196171) PubChem (40467892) PubChem (40469707) PubChem (40567592) PubChem (44135612) PubChem (44537827) PubChem (46936757) PubChem (1738053) PubChem (25323077) PubChem (44889979) PubChem (51669123) PubChem (6606) PubChem (90965613) PubChem (71113052) PubChem (6710749) PubChem (138113753) PubChem (59006268) PubChem (162937266) PubChem (59959472) PubChem (66605770) PubChem (67124956) PubChem (90361096) PubChem (91001988) PubChem (91076457) PubChem (91110453) PubChem (91744939) PubChem (91884652) PubChem (118296821) PubChem (118653772) PubChem (124903224) PubChem (124903225) PubChem (124903226) PubChem (126738532) PubChem (129370188) PubChem (130287131) PubChem (134574185) PubChem (139481096) PubChem (146159068) PubChem (154828455) PubChem (154831549) PubChem (162937264) PubChem (162937265) PubChem (162937267) PubChem (162937268) PubChem (162937269) PubChem (162937270) PubChem (169543673) PubChem (172428973) PubChem (172634347) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 514 | Chemie (HOH) |
Sequence modifications
A, B: 61 - 503 (UniProt: Q16850)
| PDB | External Database | Details |
|---|---|---|
| Met 50 | - | expression tag |
| Ala 51 | - | expression tag |
| Lys 52 | - | expression tag |
| Lys 53 | - | expression tag |
| Thr 54 | - | expression tag |
| Ser 55 | - | expression tag |
| Ser 56 | - | expression tag |
| Lys 57 | - | expression tag |
| Gly 58 | - | expression tag |
| Lys 59 | - | expression tag |
| Leu 60 | - | expression tag |
| Ala 231 | Asp 231 | engineered mutation |
| Ala 314 | His 314 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 103613.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2086.4 | |
| All* | Total formula weight | 105699.5 |
