PDB: 30476 件ウェブページステータス検索Chemie searchBIRD

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6A60	Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1 分子名称: (9cis)-retinoic acid, 3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid, Bile acid receptor, ... 著者 Wang, N, Liu, J. 登録日 2018-06-25 公開日 2018-10-10 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293, 2018
6A4Q	HEWL crystals soaked in 2.5M GuHCl for 110 minutes 分子名称: CHLORIDE ION, GLYCEROL, GUANIDINE, ... 著者 Tushar, R, Kini, R.M, Koh, C.Y, Hosur, M.V. 登録日 2018-06-20 公開日 2019-03-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 X-ray crystallographic analysis of time-dependent binding of guanidine hydrochloride to HEWL: First steps during protein unfolding. Int. J. Biol. Macromol., 122, 2019
6AI4	Structure of Transferase mutant-C21S,C199S 分子名称: Non-LEE encoded effector protein NleB 著者 Park, J.B, Yoo, Y, Kim, J. 登録日 2018-08-21 公開日 2018-10-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Transferase mutant-C21S,C199S To Be Published
6A8Q	R207A mutant of highly active EfBSH 分子名称: Bile salt hydrolase 著者 Ramasamy, S, Yadav, Y. 登録日 2018-07-10 公開日 2019-07-10 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 R207A mutant of highly active EfBSH To Be Published
6AC9	Crystal structure of human Vaccinia-related kinase 1 (VRK1) in complex with AMP-PNP 分子名称: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... 著者 Ngow, Y.S, Sreekanth, R, Yoon, H.S. 登録日 2018-07-25 公開日 2018-12-26 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Crystal structure of human vaccinia-related kinase 1 in complex with AMP-PNP, a non-hydrolyzable ATP analog. Protein Sci., 28, 2019
6AM7	Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9 分子名称: PHOSPHATE ION, SODIUM ION, Tryptophan synthase beta chain 1 著者 Buller, A.R, van Roye, P. 登録日 2017-08-09 公開日 2018-05-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble. J. Am. Chem. Soc., 140, 2018
5ZYM	Crystal structure of CERT START domain in complex with compound E25B 分子名称: 2-[4-[4-cyclopentyl-3-[(1~{R},2~{S})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol, GLYCEROL, LIPID-TRANSFER PROTEIN CERT 著者 Suzuki, M, Nakao, N, Ueno, M, Sakai, S, Egawa, D, Hanzawa, H, Kawasaki, S, Kumagai, K, Kobayashi, S, Hanada, K. 登録日 2018-05-25 公開日 2019-02-27 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT Commun Chem, 2019
6A4O	HEWL crystals soaked in 2.5M GuHCl for 20 minutes 分子名称: CHLORIDE ION, GLYCEROL, GUANIDINE, ... 著者 Tushar, R, Kini, R.M, Koh, C.Y, Hosur, M.V. 登録日 2018-06-20 公開日 2019-03-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 X-ray crystallographic analysis of time-dependent binding of guanidine hydrochloride to HEWL: First steps during protein unfolding. Int. J. Biol. Macromol., 122, 2019
6A34	Crystal structure of 5-methylthioribose 1-phosphate isomerase from Pyrococcus horikoshii OT3 - Form I 分子名称: HEXANE-1,6-DIOL, Putative methylthioribose-1-phosphate isomerase 著者 Kanaujia, S.P, Gogoi, P, Mordina, P. 登録日 2018-06-14 公開日 2018-12-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural insights into the catalytic mechanism of 5-methylthioribose 1-phosphate isomerase. J. Struct. Biol., 205, 2019
6A5H	The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of unidentified natural product 分子名称: 101015D 著者 Zhang, B, Ge, H.M. 登録日 2018-06-23 公開日 2019-02-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.618 Å) 主引用文献 Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products. Nature, 568, 2019
5I0U	Incompletely interpreted D-cysteine soak of Cysteine Dioxygenase at pH 7.0 分子名称: Cysteine dioxygenase type 1, D-CYSTEINE, FE (III) ION 著者 Kean, K.M, Driggers, C.M, Karplus, P.A. 登録日 2016-02-04 公開日 2017-02-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
8FUN	Enzymatically Active, Mn/Fe Metallated Form of AibH1H2 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Amidohydrolase, FE (III) ION, ... 著者 Powell, M.M, Rittle, J. 登録日 2023-01-17 公開日 2023-04-05 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Enzymatic Hydroxylation of Aliphatic C-H Bonds by a Mn/Fe Cofactor. J.Am.Chem.Soc., 145, 2023
8FUO	Fe-bound AibH1H2 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Amidohydrolase, FE (III) ION 著者 Powell, M.M, Rittle, J. 登録日 2023-01-17 公開日 2023-04-05 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Enzymatic Hydroxylation of Aliphatic C-H Bonds by a Mn/Fe Cofactor. J.Am.Chem.Soc., 145, 2023
8FJ2	Crystal Structure of the Tick Evasin EVA-AAM1001(C8) Complexed to Human Chemokine CCL17 分子名称: C-C motif chemokine 17, Evasin P1243 著者 Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. 登録日 2022-12-19 公開日 2023-03-29 最終更新日 2023-07-26 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins. Nat Commun, 14, 2023
8FLO	X-ray crystal structure of substrate free CYP124A1 from Mycobacterium Marinum 分子名称: Cytochrome P450 124A1, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Ghith, A, Bruning, J.B, Bell, S.G. 登録日 2022-12-22 公開日 2023-03-29 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 The catalytic activity and structure of the lipid metabolizing CYP124 cytochrome P450 enzyme from Mycobacterium marinum. Arch.Biochem.Biophys., 737, 2023
8FJO	X-ray crystal structure of CYP124A1 from Mycobacterium Marinum in complex with farnesyl acetate 分子名称: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl acetate, AMMONIUM ION, Cytochrome P450 124A1, ... 著者 Ghith, A, Bruning, J.B, Bell, S.G. 登録日 2022-12-20 公開日 2023-03-29 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 The catalytic activity and structure of the lipid metabolizing CYP124 cytochrome P450 enzyme from Mycobacterium marinum. Arch.Biochem.Biophys., 737, 2023
5I34	Adenylosuccinate synthetase from Cryptococcus neoformans complexed with GDP and IMP 分子名称: Adenylosuccinate synthetase, GUANOSINE-5'-DIPHOSPHATE, INOSINIC ACID 著者 Blundell, R.D, Williams, S.J, Ericsson, D, Fraser, J.A, Kobe, B. 登録日 2016-02-09 公開日 2016-08-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans. Acs Infect Dis., 2, 2016
7VQM	GH2 beta-galacturonate AqGalA in complex with galacturonide 分子名称: CHLORIDE ION, GH2 beta-galacturonate AqGalA, beta-D-galactopyranuronic acid 著者 Yang, J. 登録日 2021-10-20 公開日 2021-11-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and Biochemical Basis of a Marine Bacterial Glycoside Hydrolase Family 2 beta-Glycosidase with Broad Substrate Specificity Appl.Environ.Microbiol., 88, 2022
5I4N	Crystal Structure of the E596A V617F Mutant JAK2 Pseudokinase Domain Bound to Mg-ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Shiau, A.K, Motamedi, A. 登録日 2016-02-12 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 alpha C helix. Biochem.J., 473, 2016
8FV0	SpeG spermidine N-acetyltransferase from Staphylococcus aureus in complex with spermine 分子名称: Diamine N-acetyltransferase, SPERMINE 著者 Tsimbalyuk, S, Forwood, J.K. 登録日 2023-01-18 公開日 2023-04-26 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 SpeG spermidine N-acetyltransferase from Staphylococcus aureus in complex with spermine To Be Published
8FHJ	Crystal structure of a FAD monooxygenease from Methylocystis sp. Strain SB2 分子名称: BROMIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Stewart, A.M, Sawaya, M.R, Stewart, C.E. 登録日 2022-12-14 公開日 2023-05-03 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Crystal structure of MbnF: an NADPH-dependent flavin monooxygenase from Methylocystis strain SB2. Acta Crystallogr.,Sect.F, 79, 2023
8FOG	Crystal structure of human DNA polymerase eta incorporating dITP across dT 分子名称: 2'-deoxyinosine 5'-triphosphate, CALCIUM ION, DNA polymerase eta, ... 著者 Jung, H. 登録日 2022-12-30 公開日 2023-05-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Crystal structure of human DNA polymerase eta incorporating dITP across dT To Be Published
8FNY	Nucleotide-bound structure of a functional construct of eukaryotic elongation factor 2 kinase. 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... 著者 Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. 登録日 2022-12-28 公開日 2023-05-03 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin. Proc.Natl.Acad.Sci.USA, 120, 2023
7VSW	Crystal structure of a Fab-like fragment of anti-mesothelin antibody 分子名称: heavy chain, light chain 著者 Yang, Z, Ying, T. 登録日 2021-10-27 公開日 2021-12-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Design of a Novel Fab-Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use. Small Methods, 6, 2022
8FK4	Structure of the catalytic domain of Streptococcus mutans GtfB complexed to acarbose in orthorhombic space group P21212 分子名称: 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, CALCIUM ION, Glucosyltransferase-I, ... 著者 Schormann, N, Deivanayagam, C. 登録日 2022-12-20 公開日 2023-05-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 The catalytic domains of Streptococcus mutans glucosyltransferases: a structural analysis. Acta Crystallogr.,Sect.F, 79, 2023

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