PDB: 81877 件ウェブページステータス検索Chemie searchBIRD

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3RIL	The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease 分子名称: (3S,4R,5R,6S)-azepane-3,4,5,6-tetrol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, ... 著者 Orwig, S.D, Lieberman, R.L. 登録日 2011-04-13 公開日 2012-03-14 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease Biochemistry, 50, 2011
5JCJ	Trypanosoma brucei PTR1 in complex with inhibitor NMT-H037 (compound 7) 分子名称: 2-(3,4-dihydroxyphenyl)-3,6-dihydroxy-4H-1-benzopyran-4-one, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Landi, G, Pozzi, C, Di Pisa, F, Dello Iacono, L, Mangani, S. 登録日 2016-04-15 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs. J.Med.Chem., 59, 2016
4K7R	Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation 分子名称: (2S)-1-(pentanoyloxy)propan-2-yl hexanoate, Cation efflux system protein CusC 著者 Su, C.-C, Lei, H.-T, Bolla, J.R, Yu, E.W. 登録日 2013-04-17 公開日 2013-10-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.094 Å) 主引用文献 Crystal Structures of CusC Review Conformational Changes Accompanying Folding and Transmembrane Channel Formation. J.Mol.Biol., 426, 2014
6T7N	Trypanosoma cruzi farnesyl diphosphate synthase in complex with IPP and Mn 分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl diphosphate synthase, MANGANESE (II) ION 著者 Magari, F, Heine, A, Klebe, G. 登録日 2019-10-22 公開日 2020-11-18 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Trypanosoma cruzi farnesyl diphosphate synthase in complex with IPP and Mn To Be Published
3PNB	Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis in complex with coenzyme A 分子名称: COENZYME A, Phosphopantetheine adenylyltransferase 著者 Wubben, T.J, Mesecar, A.D. 登録日 2010-11-18 公開日 2011-06-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Structure of Mycobacterium tuberculosisphosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation. Acta Crystallogr.,Sect.F, 67, 2011
2H7W	Crystal structure of Chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi 分子名称: Chagasin 著者 Figueiredo da Silva, A.A, Guimaraes, B.G. 登録日 2006-06-05 公開日 2006-10-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi. J.Struct.Biol., 157, 2007
4HWY	Trypanosoma brucei procathepsin B solved from 40 fs free-electron laser pulse data by serial femtosecond X-ray crystallography 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cysteine peptidase C (CPC), beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Redecke, L, Nass, K, DePonte, D.P, White, T.A, Rehders, D, Barty, A, Stellato, F, Liang, M, Barends, T.R.M, Boutet, S, Williams, G.W, Messerschmidt, M, Seibert, M.M, Aquila, A, Arnlund, D, Bajt, S, Barth, T, Bogan, M.J, Caleman, C, Chao, T.-C, Doak, R.B, Fleckenstein, H, Frank, M, Fromme, R, Galli, L, Grotjohann, I, Hunter, M.S, Johansson, L.C, Kassemeyer, S, Katona, G, Kirian, R.A, Koopmann, R, Kupitz, C, Lomb, L, Martin, A.V, Mogk, S, Neutze, R, Shoemann, R.L, Steinbrener, J, Timneanu, N, Wang, D, Weierstall, U, Zatsepin, N.A, Spence, J.C.H, Fromme, P, Schlichting, I, Duszenko, M, Betzel, C, Chapman, H. 登録日 2012-11-09 公開日 2012-12-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser. Science, 339, 2013
3S8H	Structure of dihydrodipicolinate synthase complexed with 3-Hydroxypropanoic acid(HPA)at 2.70 A resolution 分子名称: 3-HYDROXY-PROPANOIC ACID, Dihydrodipicolinate synthase 著者 Kumar, M, Kaur, N, Kumar, S, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. 登録日 2011-05-28 公開日 2011-06-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure of dihydrodipicolinate synthase complexed with 3-Hydroxypropanoic acid(HPA)at 2.70 A resolution TO BE PUBLISHED
8PUI	human PHOX2B C-terminal domain including the polyA fragment at 298K 分子名称: Paired mesoderm homeobox protein 2B 著者 Anton, R, Trevino, M.A, Pantoja-Uceda, D, Felix, S, Babu, M, Cabrita, E.J, Zweckstetter, M, Tinnefeld, P, Vera, A.M, Oroz, J. 登録日 2023-07-17 公開日 2024-03-13 実験手法 SOLUTION NMR 主引用文献 Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions. Nat Commun, 15, 2024
8PTL	human PHOX2B C-terminal domain including the polyA fragment at 278K 分子名称: Paired mesoderm homeobox protein 2B 著者 Anton, R, Trevino, M.A, Pantoja-Uceda, D, Felix, S, Babu, M, Cabrita, E.J, Zweckstetter, M, Tinnefeld, P, Vera, A.M, Oroz, J. 登録日 2023-07-14 公開日 2024-03-13 実験手法 SOLUTION NMR 主引用文献 Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions. Nat Commun, 15, 2024
6SDP	Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment 4np 分子名称: Farnesyl diphosphate synthase, P-NITROPHENOL, SULFATE ION, ... 著者 Magari, F, Heine, A, Klebe, G. 登録日 2019-07-29 公開日 2020-08-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment 4np To Be Published
3PJQ	Trypanosoma cruzi trans-sialidase-like inactive isoform (including the natural mutation Tyr342His) in complex with lactose 分子名称: Trans-sialidase, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose 著者 Oppezzo, P, Baraibar, M, Obal, G, Pritsch, O, Alzari, P.M, Buschiazzo, A. 登録日 2010-11-10 公開日 2011-06-08 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity. Biochim.Biophys.Acta, 1814, 2011
6SE2	Trypanosoma cruzi farnesyl diphosphate synthase apo structure with zinc ions 分子名称: Farnesyl diphosphate synthase, SULFATE ION, ZINC ION 著者 Magari, F, Heine, A, Klebe, G. 登録日 2019-07-29 公開日 2020-08-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Trypanosoma cruzi farnesyl diphosphate synthase apo structure with zinc ions To Be Published
6SF9	Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment j71 分子名称: CAFFEINE, Farnesyl diphosphate synthase, SULFATE ION 著者 Magari, F, Heine, A, Klebe, G. 登録日 2019-08-01 公開日 2020-08-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment j71 To Be Published
3RK4	Structure of Rhodococcus rhodochrous haloalkane dehalogenase mutant DhaA31 分子名称: CHLORIDE ION, Haloalkane dehalogenase 著者 Lahoda, M, Stsiapanava, A, Mesters, J, Chaloupkova, R, Damborsky, J, Kuta Smatanova, I. 登録日 2011-04-17 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Crystallographic analysis of 1,2,3-trichloropropane biodegradation by the haloalkane dehalogenase DhaA31. Acta Crystallogr.,Sect.D, 70, 2014
6SDO	Trypanosoma cruzi farnesyl diphosphate synthase in complex with 3np 分子名称: 3-nitrophenol, Farnesyl diphosphate synthase, SULFATE ION, ... 著者 Magari, F, Heine, A, Klebe, G. 登録日 2019-07-29 公開日 2020-08-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Trypanosoma cruzi farnesyl diphosphate synthase in complex with 3np To Be Published
6SDN	Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment j82 分子名称: 4-NITROCATECHOL, Farnesyl diphosphate synthase, SULFATE ION, ... 著者 Magari, F, Heine, A, Klebe, G. 登録日 2019-07-29 公開日 2020-08-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment j82 To Be Published
6SFA	Trypanosoma cruzi farnesyl diphosphate synthase apo structure with Mn ions 分子名称: Farnesyl diphosphate synthase, MANGANESE (II) ION, SULFATE ION 著者 Magari, F, Heine, A, Klebe, G. 登録日 2019-08-01 公開日 2020-08-26 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Trypanosoma cruzi farnesyl diphosphate synthase apo structure with Mn ions To Be Published
6SDQ	Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment 2m5n 分子名称: 2-methoxy-5-nitro-phenol, Farnesyl diphosphate synthase, SULFATE ION, ... 著者 Magari, F, Heine, A, Klebe, G. 登録日 2019-07-29 公開日 2020-08-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment 2m5n To Be Published
4M36	Crystal structure of Trypanosoma brucei protein arginine methyltransferase 7 分子名称: Protein arginine N-methyltransferase 7 著者 Wang, C, Zhu, Y, Shi, Y. 登録日 2013-08-06 公開日 2014-04-23 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.042 Å) 主引用文献 Structural determinants for the strict monomethylation activity by trypanosoma brucei protein arginine methyltransferase 7. Structure, 22, 2014
4M37	Crystal structure of Trypanosoma brucei protein arginine methyltransferase 7 complex with AdoHcy 分子名称: Protein arginine N-methyltransferase 7, S-ADENOSYL-L-HOMOCYSTEINE 著者 Wang, C, Zhu, Y, Shi, Y. 登録日 2013-08-06 公開日 2014-04-23 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural determinants for the strict monomethylation activity by trypanosoma brucei protein arginine methyltransferase 7. Structure, 22, 2014
1TZJ	Crystal Structure of 1-aminocyclopropane-1-carboxylate deaminase complexed with d-vinyl glycine 分子名称: 1-aminocyclopropane-1-carboxylate deaminase, D-VINYLGLYCINE, PYRIDOXAL-5'-PHOSPHATE, ... 著者 Karthikeyan, S, Zhou, Q, Zhao, Z, Kao, C.L, Tao, Z, Robinson, H, Liu, H.W, Zhang, H. 登録日 2004-07-10 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Structural Analysis of Pseudomonas 1-Aminocyclopropane-1-carboxylate Deaminase Complexes: Insight into the Mechanism of a Unique Pyridoxal-5'-phosphate Dependent Cyclopropane Ring-Opening Reaction Biochemistry, 43, 2004
8OF2	Trypanosoma brucei pteridine reductase 1 (TbPTR1) in complex with 2,4,6 triamminopyrimidine (TAP) 分子名称: 1,2-ETHANEDIOL, ACETATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Tassone, G, Landi, G, Mangani, S, Pozzi, C. 登録日 2023-03-13 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents. Eur.J.Med.Chem., 264, 2023
3P54	Crystal Structure of the Japanese Encephalitis Virus Envelope Protein, strain SA-14-14-2. 分子名称: envelope glycoprotein 著者 Luca, V.C, Nelson, C.A, AbiMansour, J.P, Diamond, M.S, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2010-10-07 公開日 2010-12-08 最終更新日 2012-02-08 実験手法 X-RAY DIFFRACTION (2.097 Å) 主引用文献 Crystal structure of the Japanese encephalitis virus envelope protein. J.Virol., 86, 2012
3PAC	Crystal structure of PduT a trimeric bacterial microcompartment protein with 4Fe-4S cluster binding site 分子名称: Shell protein 著者 Pang, A.H, Warren, M.J, Pickersgill, R.W. 登録日 2010-10-19 公開日 2010-12-01 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Structure of PduT, a trimeric bacterial microcompartment protein with a 4Fe-4S cluster-binding site Acta Crystallogr.,Sect.D, 67, 2011

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