PDB: 5425 件ウェブページステータス検索Chemie searchBIRD

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6TED	Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric elongation activation by RTF1 分子名称: DNA (37-MER), DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase subunit, ... 著者 Vos, S.M, Farnung, L, Cramer, P. 登録日 2019-11-11 公開日 2020-07-22 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation. Nat.Struct.Mol.Biol., 27, 2020
6T7B	Structure of human Sox2 transcription factor in complex with a nucleosome 分子名称: DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... 著者 Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P. 登録日 2019-10-21 公開日 2020-04-29 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (5.1 Å) 主引用文献 Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature, 580, 2020
4H9P	Complex structure 3 of DAXX/H3.3(sub5,G90A)/H4 分子名称: Death domain-associated protein 6, Histone H3.3, Histone H4, ... 著者 Elsasser, S.J, Huang, H, Lewis, P.W, Chin, J.W, Allis, D.C, Patel, D.J. 登録日 2012-09-24 公開日 2012-10-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.198 Å) 主引用文献 DAXX chaperone envelops an H3.3/H4 dimer dictating H3.3-specific read out To be Published
4H75	Crystal structure of human Spindlin1 in complex with a histone H3K4(me3) peptide 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, Histone H3, ... 著者 Yang, N, Wang, W, Wang, Y, Wang, M, Zhao, Q, Rao, Z, Zhu, B, Xu, R.M. 登録日 2012-09-20 公開日 2012-10-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.098 Å) 主引用文献 Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. Proc.Natl.Acad.Sci.USA, 109, 2012
2P1B	Crystal structure of human nucleophosmin-core 分子名称: Nucleophosmin 著者 Lee, H.H, Kim, H.S, Kang, J.Y, Lee, B.I, Ha, J.Y, Yoon, H.J, Lim, S.O, Jung, G, Suh, S.W. 登録日 2007-03-03 公開日 2007-03-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface Proteins, 69, 2007
4FXF	Structure of M2 pyruvate kinase in complex with phenylalanine 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Walkinshaw, M.D, Morgan, H.P. 登録日 2012-07-03 公開日 2013-03-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation. Proc.Natl.Acad.Sci.USA, 110, 2013
4HGA	Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX 分子名称: Death domain-associated protein 6, Histone H3.3, Histone H4, ... 著者 Liu, C.P, Xiong, C.Y, Wang, M.Z, Yu, Z.L, Yang, N, Chen, P, Zhang, Z.G, Li, G.H, Xu, R.M. 登録日 2012-10-07 公開日 2012-11-07 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.799 Å) 主引用文献 Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Nat.Struct.Mol.Biol., 19, 2012
4GQB	Crystal Structure of the human PRMT5:MEP50 Complex 分子名称: (2S,5S,6E)-2,5-diamino-6-[(3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxydihydrofuran-2(3H)-ylidene]hexanoic acid, Histone H4 peptide, Methylosome protein 50, ... 著者 Antonysamy, S, Bonday, Z, Campbell, R, Doyle, B, Druzina, Z, Gheyi, T, Han, B, Jungheim, L.N, Qian, Y, Rauch, C, Russell, M, Sauder, J.M, Wasserman, S.R, Weichert, K, Willard, F.S, Zhang, A, Emtage, S. 登録日 2012-08-22 公開日 2012-10-17 最終更新日 2018-11-21 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Crystal structure of the human PRMT5:MEP50 complex. Proc.Natl.Acad.Sci.USA, 109, 2012
4GUT	Crystal structure of LSD2-NPAC 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1B, ... 著者 Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. 登録日 2012-08-29 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
4H9N	Complex structure 1 of DAXX/H3.3(sub5)/H4 分子名称: Death domain-associated protein 6, Histone H3.3, Histone H4, ... 著者 Elsasser, S.J, Huang, H, Lewis, P.W, Chin, J.W, Allis, D.C, Patel, D.J. 登録日 2012-09-24 公開日 2012-10-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 DAXX chaperone envelops an H3.3/H4 dimer dictating H3.3-specific read out To be Published
4JPG	2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as Novel PKM2 Activators 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 2-(1H-benzimidazol-1-ylmethyl)-4H-pyrido[1,2-a]pyrimidin-4-one, Pyruvate kinase isozymes M1/M2 著者 Greasley, S.E, Hickey, M, Phonephaly, H, Cronin, C. 登録日 2013-03-19 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators. Bioorg.Med.Chem.Lett., 23, 2013
7TUB	The beta-tubulin folding intermediate IV 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... 著者 Zhao, Y, Frydman, J, Chiu, W. 登録日 2022-02-02 公開日 2022-12-28 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT. Cell, 185, 2022
7TRG	The beta-tubulin folding intermediate I 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... 著者 Zhao, Y, Frydman, J, Chiu, W. 登録日 2022-01-28 公開日 2022-12-28 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT. Cell, 185, 2022
7TTN	The beta-tubulin folding intermediate II 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... 著者 Zhao, Y, Frydman, J, Chiu, W. 登録日 2022-02-01 公開日 2022-12-28 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT. Cell, 185, 2022
7TTT	The beta-tubulin folding intermediate III 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... 著者 Zhao, Y, Frydman, J, Chiu, W. 登録日 2022-02-01 公開日 2022-12-28 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT. Cell, 185, 2022
4OPX	Structure of Human PARP-1 bound to a DNA double strand break in complex with (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide 分子名称: (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide, DNA (26-MER), Poly [ADP-ribose] polymerase 1, ... 著者 Pascal, J.M, Steffen, J.D. 登録日 2014-02-06 公開日 2014-07-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.314 Å) 主引用文献 Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors. J.Med.Chem., 57, 2014
4OQB	Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-{4-[2-(morpholin-4-yl)ethoxy]benzylidene}-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide 分子名称: (2Z)-2-{4-[2-(morpholin-4-yl)ethoxy]benzylidene}-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide, DNA (26-MER), Poly [ADP-ribose] polymerase 1, ... 著者 Pascal, J.M, Steffen, J.D. 登録日 2014-02-07 公開日 2014-07-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.362 Å) 主引用文献 Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors. J.Med.Chem., 57, 2014
7VBA	Structure of the pre state human RNA Polymerase I Elongation Complex 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (5'-D(P*A*CP*TP*GP*TP*CP*CP*TP*CP*TP*GP*GP*C)-3'), DNA (5'-D(P*GP*CP*CP*AP*GP*AP*GP*AP*CP*AP*GP*CP*GP*AP*GP*TP*CP*AP*GP*CP*AP*A)-3'), ... 著者 Zhao, D, Liu, W, Chen, K, Yang, H, Xu, Y. 登録日 2021-08-31 公開日 2022-02-16 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Structure of the human RNA polymerase I elongation complex. Cell Discov, 7, 2021
7VBC	Back track state of human RNA Polymerase I Elongation Complex 分子名称: DNA (5'-D(*GP*TP*AP*CP*TP*GP*TP*CP*CP*TP*CP*TP*GP*G)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*AP*GP*CP*GP*TP*GP*TP*CP*AP*GP*CP*AP*AP*TP*A)-3'), DNA-directed RNA polymerase I subunit RPA1, ... 著者 Zhao, D, Liu, W, Chen, K, Yang, H, Xu, Y. 登録日 2021-08-31 公開日 2022-02-16 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structure of the human RNA polymerase I elongation complex. Cell Discov, 7, 2021
7VBB	Structure of the post state human RNA Polymerase I Elongation Complex 分子名称: DNA (25-MER), DNA (5'-D(*CP*TP*GP*TP*CP*CP*TP*CP*TP*GP*GP*CP*GP*A)-3'), DNA-directed RNA polymerase I subunit RPA1, ... 著者 Zhao, D, Liu, W, Chen, K, Yang, H, Xu, Y. 登録日 2021-08-31 公開日 2022-03-02 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Structure of the human RNA polymerase I elongation complex. Cell Discov, 7, 2021
4QGC	crystal structure of PKM2-K422R mutant 分子名称: GLYCEROL, POTASSIUM ION, Pyruvate kinase PKM, ... 著者 Wang, P, Sun, C, Zhu, T, Xu, Y. 登録日 2014-05-22 公開日 2015-02-25 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.296 Å) 主引用文献 Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell, 6, 2015
4QG6	crystal structure of PKM2-Y105E mutant 分子名称: PROLINE, Pyruvate kinase PKM 著者 Wang, P, Sun, C, Zhu, T, Xu, Y. 登録日 2014-05-22 公開日 2015-02-25 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.207 Å) 主引用文献 Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell, 6, 2015
4QG9	crystal structure of PKM2-R399E mutant 分子名称: ACETATE ION, MAGNESIUM ION, Pyruvate kinase PKM 著者 Wang, P, Sun, C, Zhu, T, Xu, Y. 登録日 2014-05-22 公開日 2015-02-25 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.381 Å) 主引用文献 Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell, 6, 2015
7V1M	Structural basis for the co-chaperone relationship of sNASP and ASF1b 分子名称: Histone H3.3, Histone H4, Histone chaperone ASF1B, ... 著者 Bao, H, Huang, H. 登録日 2021-08-04 公開日 2022-04-20 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.834 Å) 主引用文献 NASP maintains histone H3-H4 homeostasis through two distinct H3 binding modes. Nucleic Acids Res., 50, 2022
7UCJ	Mammalian 80S translation initiation complex with mRNA and Harringtonine 分子名称: 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... 著者 Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. 登録日 2022-03-16 公開日 2022-06-01 最終更新日 2022-08-17 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Mol.Cell, 82, 2022

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