1YKZ
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![BU of 1ykz by Molmil](/molmil-images/mine/1ykz) | Effect of alcohols on protein hydration | 分子名称: | CHLORIDE ION, Lysozyme C, PENTANAL, ... | 著者 | Deshpande, A, Nimsadkar, S, Mande, S.C. | 登録日 | 2005-01-18 | 公開日 | 2005-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Effect of alcohols on protein hydration: crystallographic analysis of hen egg-white lysozyme in the presence of alcohols. Acta Crystallogr.,Sect.D, 61, 2005
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1YJB
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![BU of 1yjb by Molmil](/molmil-images/mine/1yjb) | SUBTILISIN BPN' 8397+1 (E.C. 3.4.21.14) (MUTANT WITH MET 50 REPLACED BY PHE, ASN 76 REPLACED BY ASP, GLY 169 REPLACED BY ALA, GLN 206 REPLACED BY CYS, ASN 218 REPLACED BY SER AND LYS 256 REPLACED BY TYR) (M50F, N76D, G169A, Q206C, N218S, AND K256Y) IN 35% DIMETHYLFORMAMIDE | 分子名称: | CALCIUM ION, SUBTILISIN 8397+1 | 著者 | Kidd, R.D, Farber, G.K. | 登録日 | 1996-01-16 | 公開日 | 1996-07-11 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Breaking the low barrier hydrogen bond in a serine protease. Protein Sci., 8, 1999
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6DCD
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1YL0
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![BU of 1yl0 by Molmil](/molmil-images/mine/1yl0) | Effect of alcohols on protein hydration | 分子名称: | CHLORIDE ION, ISOPROPYL ALCOHOL, Lysozyme C, ... | 著者 | Deshpande, A, Nimsadkar, S, Mande, S.C. | 登録日 | 2005-01-18 | 公開日 | 2005-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Effect of alcohols on protein hydration: crystallographic analysis of hen egg-white lysozyme in the presence of alcohols. Acta Crystallogr.,Sect.D, 61, 2005
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1YL1
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![BU of 1yl1 by Molmil](/molmil-images/mine/1yl1) | Effect of alcohols on protein hydration | 分子名称: | Lysozyme C, SODIUM ION, TRIFLUOROETHANOL | 著者 | Deshpande, A.A, Nimsadkar, S, Mande, S.C. | 登録日 | 2005-01-18 | 公開日 | 2005-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Effect of alcohols on protein hydration: crystallographic analysis of hen egg-white lysozyme in the presence of alcohols. Acta Crystallogr.,Sect.D, 61, 2005
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1YM0
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![BU of 1ym0 by Molmil](/molmil-images/mine/1ym0) | Crystal Structure of Earthworm Fibrinolytic Enzyme Component B: a Novel, Glycosylated Two-chained Trypsin | 分子名称: | MAGNESIUM ION, SULFATE ION, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, F, Wang, C, Li, M, Zhang, J.P, Gui, L.L, An, X.M, Chang, W.R. | 登録日 | 2005-01-20 | 公開日 | 2005-04-19 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Crystal structure of earthworm fibrinolytic enzyme component B: a novel, glycosylated two-chained trypsin. J.Mol.Biol., 348, 2005
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6DI8
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![BU of 6di8 by Molmil](/molmil-images/mine/6di8) | Crystal structure of bovine alpha-chymotrypsin in space group P65 | 分子名称: | Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... | 著者 | Marshall, A.C, Keiller, B.G, Bruning, J.B. | 登録日 | 2018-05-23 | 公開日 | 2019-01-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.859 Å) | 主引用文献 | Crystal Structure of Bovine Alpha-Chymotrypsin in Space Group P65 Crystals, 8, 2018
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6DCG
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![BU of 6dcg by Molmil](/molmil-images/mine/6dcg) | Discovery of MK-8353: An Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology | 分子名称: | (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | Boga, S.B, Deng, Y, Zhu, L, Nan, Y, Cooper, A, Shipps Jr, G.W, Doll, R, Shih, N, Zhu, H, Sun, R, Wang, T, Paliwal, S, Tsui, H, Gao, X, Yao, X, Desai, J, Wang, J, Alhassan, A.B, Kelly, J, Patel, M, Muppalla, K, Gudipati, S, Zhang, L, Buevich, A, Hesk, D, Carr, D, Dayananth, P, Mei, H, Cox, K, Sherborne, B, Hruza, A.W, Xiao, L, Jin, W, Long, B, Liu, G, Taylor, S.A, Kirschmeier, P, Windsor, W.T, Bishop, R, Samatar, A.A. | 登録日 | 2018-05-06 | 公開日 | 2018-08-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology. ACS Med Chem Lett, 9, 2018
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6DJ1
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![BU of 6dj1 by Molmil](/molmil-images/mine/6dj1) | Wild-type HIV-1 protease in complex with Lopinavir | 分子名称: | CHLORIDE ION, HIV-1 protease, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... | 著者 | Wang, Y.-F, Wong-Sam, A.E, Zhang, Y, Weber, I.T. | 登録日 | 2018-05-24 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease. ACS Omega, 3, 2018
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6DJM
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![BU of 6djm by Molmil](/molmil-images/mine/6djm) | Cryo-EM structure of AMPPNP-actin filaments | 分子名称: | Actin, alpha skeletal muscle, MAGNESIUM ION, ... | 著者 | Chou, S.Z, Pollard, T.D. | 登録日 | 2018-05-25 | 公開日 | 2019-02-27 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides. Proc.Natl.Acad.Sci.USA, 116, 2019
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1YPU
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![BU of 1ypu by Molmil](/molmil-images/mine/1ypu) | |
1YN8
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![BU of 1yn8 by Molmil](/molmil-images/mine/1yn8) | |
6DH0
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![BU of 6dh0 by Molmil](/molmil-images/mine/6dh0) | Crystal structure of HIV-1 Protease NL4-3 I84V Mutant in complex with darunavir | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease | 著者 | Lockbaum, G.J, Schiffer, C.A. | 登録日 | 2018-05-18 | 公開日 | 2018-12-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | 主引用文献 | Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5, 2019
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6DH8
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![BU of 6dh8 by Molmil](/molmil-images/mine/6dh8) | Crystal structure of HIV-1 Protease NL4-3 I50V Mutant in complex with UMass6 | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-ethylbutyl)amino}-1-benzyl-2-hydroxypropyl]carbamate, Protease, SULFATE ION | 著者 | Lockbaum, G.J, Schiffer, C.A. | 登録日 | 2018-05-18 | 公開日 | 2018-12-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.951 Å) | 主引用文献 | Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5, 2019
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6DI4
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6DJ7
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![BU of 6dj7 by Molmil](/molmil-images/mine/6dj7) | HIV-1 protease with mutation L76V in complex with GRL-5010 (gem-difluoro-bis-tetrahydrofuran as P2 ligand) | 分子名称: | (3R,3aS,6aS)-4,4-difluorohexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate, ACETATE ION, CHLORIDE ION, ... | 著者 | Wong-Sam, A.E, Wang, Y.F, Weber, I.T. | 登録日 | 2018-05-24 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease. ACS Omega, 3, 2018
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6DUJ
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6DWQ
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![BU of 6dwq by Molmil](/molmil-images/mine/6dwq) | Subtilisin serine protease modified with the protease inhibitor cyanobenzylsulfonylfluoride | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, KerA, ... | 著者 | Luo, M, Eaton, C.N, Phillips-Piro, C.M. | 登録日 | 2018-06-27 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Paired Spectroscopic and Crystallographic Studies of Protease Active Sites Chemistryselect, 4, 2019
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6D40
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8WZT
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![BU of 8wzt by Molmil](/molmil-images/mine/8wzt) | SFX structure of an Mn-carbonyl complex immobilized in hen egg white lysozyme microcrystals, 1 microsecond after photoexcitation at RT. | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION, ... | 著者 | Maity, B, Shoji, M, Luo, F, Nakane, T, Abe, S, Owada, S, Kang, J, Tono, K, Tanaka, R, Thuc, T.T, Kojima, M, Hishikawa, Y, Tanaka, J, Tian, J, Noya, H, Nakasuji, Y, Asanuma, A, Yao, X, Iwata, S, Shigeta, Y, Nango, E, Ueno, T. | 登録日 | 2023-11-02 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Real-time observation of a metal complex-driven reaction intermediate using a porous protein crystal and serial femtosecond crystallography. Nat Commun, 15, 2024
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8WZF
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![BU of 8wzf by Molmil](/molmil-images/mine/8wzf) | Dark state SFX structure of hen egg white lysozyme microcrystals immobilized with a Mn carbonyl complex at RT. | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION, ... | 著者 | Maity, B, Shoji, M, Luo, F, Nakane, T, Abe, S, Owada, S, Kang, J, Tono, K, Tanaka, R, Thuc, T.T, Kojima, M, Hishikawa, Y, Tanaka, J, Tian, J, Noya, H, Nakasuji, Y, Asanuma, A, Yao, X, Iwata, S, Shigeta, Y, Nango, E, Ueno, T. | 登録日 | 2023-11-01 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Real-time observation of a metal complex-driven reaction intermediate using a porous protein crystal and serial femtosecond crystallography. Nat Commun, 15, 2024
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8WZG
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![BU of 8wzg by Molmil](/molmil-images/mine/8wzg) | SFX structure of an Mn-carbonyl complex immobilized in hen egg white lysozyme microcrystals, 10 ns after photoexcitation at RT. | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION, ... | 著者 | Maity, B, Shoji, M, Luo, F, Nakane, T, Abe, S, Owada, S, Kang, J, Tono, K, Tanaka, R, Thuc, T.T, Kojima, M, Hishikawa, Y, Tanaka, J, Tian, J, Noya, H, Nakasuji, Y, Asanuma, A, Yao, X, Iwata, S, Shigeta, Y, Nango, E, Ueno, T. | 登録日 | 2023-11-01 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Real-time observation of a metal complex-driven reaction intermediate using a porous protein crystal and serial femtosecond crystallography. Nat Commun, 15, 2024
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8WZV
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![BU of 8wzv by Molmil](/molmil-images/mine/8wzv) | SFX structure of an Mn-carbonyl complex immobilized in hen egg white lysozyme microcrystals, 1 microsecond after photoexcitation with 40 microJoules laser intensity at RT. | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION, ... | 著者 | Maity, B, Shoji, M, Luo, F, Nakane, T, Abe, S, Owada, S, Kang, J, Tono, K, Tanaka, R, Thuc, T.T, Kojima, M, Hishikawa, Y, Tanaka, J, Tian, J, Noya, H, Nakasuji, Y, Asanuma, A, Yao, X, Iwata, S, Shigeta, Y, Nango, E, Ueno, T. | 登録日 | 2023-11-02 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Real-time observation of a metal complex-driven reaction intermediate using a porous protein crystal and serial femtosecond crystallography. Nat Commun, 15, 2024
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8WKY
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![BU of 8wky by Molmil](/molmil-images/mine/8wky) | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S25 | 分子名称: | CALCIUM ION, Melanocortin receptor 4, N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)pyridine-3-carboxamide, ... | 著者 | Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S. | 登録日 | 2023-09-28 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. J.Med.Chem., 67, 2024
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8WKZ
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![BU of 8wkz by Molmil](/molmil-images/mine/8wkz) | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S31 | 分子名称: | CALCIUM ION, Melanocortin receptor 4, OLEIC ACID, ... | 著者 | Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S. | 登録日 | 2023-09-28 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. J.Med.Chem., 67, 2024
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