PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

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8PSS	Tilapia Lake Virus polymerase in cRNA pre-initiation state mode B (core-endo only) 分子名称: 5' cRNA end - cRNA loop (40-mer), MAGNESIUM ION, Polymerase acidic protein (PA-like), ... 著者 Arragain, B, Cusack, S. 登録日 2023-07-13 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family. Nat Commun, 14, 2023
8PT6	Tilapia Lake Virus polymerase in vRNA initiation state (replicase conformation) 分子名称: 5' vRNA end - vRNA loop (40-mer), DNA (5'-D(*(CTP))-3'), MAGNESIUM ION, ... 著者 Arragain, B, Cusack, S. 登録日 2023-07-13 公開日 2023-12-27 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family. Nat Commun, 14, 2023
8PSZ	Tilapia Lake Virus polymerase in vRNA elongation state with additional mode B promoter (transcriptase conformation) 分子名称: 5' vRNA end - vRNA loop (40-mer), MAGNESIUM ION, Polymerase acidic protein (PA-like), ... 著者 Arragain, B, Cusack, S. 登録日 2023-07-13 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (2.42 Å) 主引用文献 Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family. Nat Commun, 14, 2023
8POH	Influenza A/H7N9 polymerase symmetric dimer bound to the promoter (PA K289A/C489R) 分子名称: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... 著者 Arragain, B, Cusack, S. 登録日 2023-07-04 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8PNQ	Influenza A/H7N9 polymerase in elongation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, ... 著者 Arragain, B, Cusack, S. 登録日 2023-06-30 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8PNP	Influenza A/H7N9 polymerase in pre-initiation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A 分子名称: 51-mer vRNA loop (v51_mut_S), Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Arragain, B, Cusack, S. 登録日 2023-06-30 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (2.49 Å) 主引用文献 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8PM0	Influenza A/H7N9 polymerase in replicase-like conformation in pre-initiation state with Pol II pS5 CTD peptide mimic bound in site 1A/2A 分子名称: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... 著者 Arragain, B, Cusack, S. 登録日 2023-06-27 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8T94	Influenza PAN endonuclease with 6-(4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid 分子名称: (6M)-3-hydroxy-4-oxo-6-[(4M)-4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-2-carboxylic acid, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Cohen, S.M. 登録日 2023-06-23 公開日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry, 63, 2024
8T81	Influenza PAN endonuclease E23K mutant with 6-(4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid 分子名称: (6M)-3-hydroxy-4-oxo-6-[(4M)-4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-2-carboxylic acid, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Cohen, S.M. 登録日 2023-06-21 公開日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry, 63, 2024
8JSL	The structure of EBOV L-VP35-RNA complex 分子名称: Polymerase cofactor VP35, RNA-directed RNA polymerase L, The leader sequence of EBOV, ... 著者 Qi, P, Yi, S. 登録日 2023-06-20 公開日 2023-09-27 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Molecular mechanism of de novo replication by the Ebola virus polymerase. Nature, 622, 2023
8JSN	The structure of EBOV L-VP35-RNA complex (conformation 2) 分子名称: Polymerase cofactor VP35, RNA-directed RNA polymerase L, The leader sequence of EBOV genome, ... 著者 Qi, P, Yi, S. 登録日 2023-06-20 公開日 2023-09-27 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Molecular mechanism of de novo replication by the Ebola virus polymerase. Nature, 622, 2023
8JSM	The structure of EBOV L-VP35-RNA complex (conformation 1) 分子名称: Polymerase cofactor VP35, RNA-directed RNA polymerase L, The leader sequence of EBOV genome., ... 著者 Qi, P, Yi, S. 登録日 2023-06-20 公開日 2023-09-27 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Molecular mechanism of de novo replication by the Ebola virus polymerase. Nature, 622, 2023
8T6Z	Influenza PAN endonuclease I38T mutant with 6-(4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid 分子名称: (6M)-3-hydroxy-4-oxo-6-[(4M)-4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-2-carboxylic acid, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Cohen, S.M. 登録日 2023-06-19 公開日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry, 63, 2024
8T67	Influenza PA-N Endonuclease I38T Mutant (amino acids 52-74 truncation) 分子名称: MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Cohen, S.M. 登録日 2023-06-15 公開日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry, 63, 2024
8T5W	Influenza PAN endonuclease I38T mutant with Baloxavir 分子名称: Baloxavir acid, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Cohen, S.M. 登録日 2023-06-14 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry, 63, 2024
8T5Z	Influenza PA-N Endonuclease (amino acids 52-74 truncation) 分子名称: MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Cohen, S.M. 登録日 2023-06-14 公開日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry, 63, 2024
8PEG	Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... 著者 Fluegel, T, Schacherl, M. 登録日 2023-06-13 公開日 2024-03-06 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM. Nat Commun, 15, 2024
8T12	Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered. 分子名称: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION 著者 Biswal, M, Lu, J, Song, J. 登録日 2023-06-01 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered. To Be Published
8T13	Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 disordered 分子名称: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION 著者 Biswal, M, Lu, J, Song, J. 登録日 2023-06-01 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 disordered To Be Published
8JH2	RNA polymerase II elongation complex bound with Elf1, Spt4/5 and foreign DNA, stalled at SHL(-1) of the nucleosome 分子名称: DNA (218-MER), DNA (40-MER), DNA-directed RNA polymerase subunit, ... 著者 Akatsu, M, Fujita, R, Ogasawara, M, Ehara, H, Kujirai, T, Takizawa, Y, Sekine, S, Kurumizaka, H. 登録日 2023-05-22 公開日 2023-11-29 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (5.7 Å) 主引用文献 Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA. J.Biol.Chem., 299, 2023
8JH4	RNA polymerase II elongation complex containing 60 bp upstream DNA loop, stalled at SHL(-1) of the nucleosome 分子名称: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... 著者 Akatsu, M, Fujita, R, Ogasawara, M, Ehara, H, Kujirai, T, Takizawa, Y, Sekine, S, Kurumizaka, H. 登録日 2023-05-22 公開日 2023-11-29 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA. J.Biol.Chem., 299, 2023
8JH3	RNA polymerase II elongation complex containing 40 bp upstream DNA loop, stalled at SHL(-1) of the nucleosome 分子名称: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... 著者 Akatsu, M, Fujita, R, Ogasawara, M, Ehara, H, Kujirai, T, Takizawa, Y, Sekine, S, Kurumizaka, H. 登録日 2023-05-22 公開日 2023-11-29 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA. J.Biol.Chem., 299, 2023
8P4F	Structural insights into human co-transcriptional capping - structure 6 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (38-MER), ... 著者 Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. 登録日 2023-05-20 公開日 2023-07-19 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural insights into human co-transcriptional capping. Mol.Cell, 2023
8P4E	Structural insights into human co-transcriptional capping - structure 5 分子名称: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (26-MER), DNA (35-MER), ... 著者 Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. 登録日 2023-05-20 公開日 2023-07-19 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural insights into human co-transcriptional capping. Mol.Cell, 2023
8P4A	Structural insights into human co-transcriptional capping - structure 1 分子名称: DNA (29-MER), DNA (38-MER), DNA-directed RNA polymerase II subunit E, ... 著者 Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. 登録日 2023-05-20 公開日 2023-08-16 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural insights into human co-transcriptional capping. Mol.Cell, 83, 2023

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