9G34
 
 | | The HIV protease inhibitor darunavir binding to the active site of Cryphonectria parasitica endothiapepsin | | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | | 著者 | Falke, S, Senst, J.M, Guenther, S, Meents, A. | | 登録日 | 2024-07-11 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The HIV protease inhibitor darunavir binding to the active site of Cryphonectria
parasitica endothiapepsin
To Be Published
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9G35
 | | The HIV protease inhibitor lopinavir binding to the active site of Cryphonectria parasitica endothiapepsin | | 分子名称: | 1,2-ETHANEDIOL, Endothiapepsin, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... | | 著者 | Falke, S, Senst, J.M, Guenther, S, Meents, A. | | 登録日 | 2024-07-11 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The HIV protease inhibitor lopinavir binding to the active site of Cryphonectria parasitica endothiapepsin
To Be Published
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9IPU
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9G2A
 | | Staphylococcus aureus MazF in complex with nanobody 4 | | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Endoribonuclease MazF, ... | | 著者 | Prolic-Kalinsek, M, Zorzini, V, Haesaerts, S, Loris, R. | | 登録日 | 2024-07-10 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.046594 Å) | | 主引用文献 | Staphylococcus aureus MazF in complex with nanobody 4.
To Be Published
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9G2G
 | | Staphylococcus aureus MazF in complex with nanobody 5 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endoribonuclease MazF, Nanobody 5 | | 著者 | Prolic-Kalinsek, M, Zorzini, V, Haesaerts, S, Loris, R. | | 登録日 | 2024-07-10 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.80048239 Å) | | 主引用文献 | Nanobody-mediated activation and inhibition of Staphylococcus aureus MazF
To Be Published
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9G1Y
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9CKV
 | | Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Werther, R, Nguyen, A, Estrada Alamo, K.A, Wang, X, Campbell, M.G. | | 登録日 | 2024-07-09 | | 公開日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | De Novo Design of Integrin alpha5beta1 Modulating Proteins for Regenerative Medicine
To Be Published
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9G11
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9CK0
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9CK3
 | | Cryo-EM structure of in-vitro alpha-synuclein fibril | | 分子名称: | Alpha-synuclein | | 著者 | Sanchez, J.C, Borcik, C.G, Tonelli, M, Sibert, B, Rienstra, C.M, Wright, E.R. | | 登録日 | 2024-07-08 | | 公開日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.04 Å) | | 主引用文献 | Multimodal High-Resolution Structure Determination Of Alpha-Synuclein Fibrils
To Be Published
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9CJ9
 | | Crystal structure of human polymerase eta with incoming dAMPnPP nucleotide opposite O4-methyl threofuranosyl thymidine in DNA template at insertion stage | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(TFT)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... | | 著者 | Tomar, R, Stone, M.P, Egli, M. | | 登録日 | 2024-07-05 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.
Biochemistry, 63, 2024
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9FZK
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9FZC
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9FZD
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9CIW
 | | Penguinpox cGAMP PDE H72A mutant in complex with 2'3'-cGAMP | | 分子名称: | Penguinpox cGAMP PDE, [(2~{R},3~{R},4~{R},5~{S})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl [(2~{R},3~{R},4~{S},5~{R})-2-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-5-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl] hydrogen phosphate | | 著者 | Hobbs, S.J, Nomburg, J, Doudna, J.A, Kranzusch, P.J. | | 登録日 | 2024-07-05 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Animal and bacterial viruses share conserved mechanisms of immune evasion.
Cell, 187, 2024
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9FZO
 | | Pseudomonas aeruginosa penicillin binding protein 3 in complex with ceftazidime | | 分子名称: | ACYLATED CEFTAZIDIME, Peptidoglycan D,D-transpeptidase FtsI, SULFATE ION | | 著者 | Smith, H.G, Allen, M.D, Basak, S, Aniebok, V, Beech, M.J, Alshref, F.M, Farley, A.J.M, Schofield, C.J. | | 登録日 | 2024-07-05 | | 公開日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis of Pseudomonas aeruginosa penicillin binding protein 3 inhibition by the siderophore-antibiotic cefiderocol.
Chem Sci, 2024
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9FZP
 | | Pseudomonas aeruginosa penicillin binding protein 3 in complex with cefepime | | 分子名称: | CEFOTAXIME, C3' cleaved, open, ... | | 著者 | Smith, H.G, Allen, M.D, Basak, S, Aniebok, V, Beech, M.J, Alshref, F.M, Farley, A.J.M, Schofield, C.J. | | 登録日 | 2024-07-05 | | 公開日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis of Pseudomonas aeruginosa penicillin binding protein 3 inhibition by the siderophore-antibiotic cefiderocol.
Chem Sci, 2024
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9CIQ
 | | Crystal structure of human polymerase eta with incoming threofuranosyl thymine nucleoside triphosphate opposite template dA | | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | | 著者 | Patra, A, Tomar, R, Stone, M.P, Egli, M. | | 登録日 | 2024-07-04 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.
Biochemistry, 63, 2024
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9FZ8
 | | Pseudomonas aeruginosa penicillin binding protein 3 | | 分子名称: | Peptidoglycan D,D-transpeptidase FtsI | | 著者 | Smith, H.G, Allen, M.D, Basak, S, Aniebok, V, Beech, M.J, Alshref, F.M, Farley, A.J.M, Schofield, C.J. | | 登録日 | 2024-07-04 | | 公開日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Structural basis of Pseudomonas aeruginosa penicillin binding protein 3 inhibition by the siderophore-antibiotic cefiderocol.
Chem Sci, 2024
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9FZ7
 | | Pseudomonas aeruginosa penicillin binding protein 3 in complex with cefiderocol | | 分子名称: | ACYLATED CEFTAZIDIME, Peptidoglycan D,D-transpeptidase FtsI | | 著者 | Smith, H.G, Allen, M.D, Basak, S, Aniebok, V, Beech, M.J, Alshref, F.M, Farley, A.J.M, Schofield, C.J. | | 登録日 | 2024-07-04 | | 公開日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis of Pseudomonas aeruginosa penicillin binding protein 3 inhibition by the siderophore-antibiotic cefiderocol.
Chem Sci, 2024
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9FYO
 | | Lacto-N-biosidase from Trueperella pyogenes | | 分子名称: | NICKEL (II) ION, TrpyGH20, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Vuillemin, M, Siebenhaar, S, Zeuner, B, Morth, J.P. | | 登録日 | 2024-07-03 | | 公開日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | Discovery of Lacto-N-biosidases and a Novel N-Acetyllactosaminidase Activity in the CAZy Family GH20: Functional Diversity and Structural Insights.
Chembiochem, 2024
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9CIH
 | | Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide across O4-methyl threofuranosyl thymidine in DNA template at extension stage | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), DNA (5'-D(*CP*AP*TP*GP*(A1A0L)P*TP*GP*AP*CP*GP*CP*T)-3'), ... | | 著者 | Tomar, R, Stone, M.P, Egli, M. | | 登録日 | 2024-07-03 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.
Biochemistry, 63, 2024
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9FYL
 | | Lacto-N-biosidase from Treponema denticola ATCC 35405, HisTag bound in active site | | 分子名称: | Glycoside hydrolase family 20 catalytic domain-containing protein, ZINC ION | | 著者 | Vuillemin, M, Siebenhaar, S, Zeuner, B, Morth, J.P. | | 登録日 | 2024-07-03 | | 公開日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Discovery of Lacto-N-biosidases and a Novel N-Acetyllactosaminidase Activity in the CAZy Family GH20: Functional Diversity and Structural Insights.
Chembiochem, 2024
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9FYM
 | | Lacto-N-biosidase from Treponema denticola ATCC 35405 | | 分子名称: | Glycoside hydrolase family 20 catalytic domain-containing protein, IMIDAZOLE, SODIUM ION, ... | | 著者 | Vuillemin, M, Siebenhaar, S, Zeuner, B, Morth, J.P. | | 登録日 | 2024-07-03 | | 公開日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Discovery of Lacto-N-biosidases and a Novel N-Acetyllactosaminidase Activity in the CAZy Family GH20: Functional Diversity and Structural Insights.
Chembiochem, 2024
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9FYP
 | | Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH. | | 分子名称: | Alpha-synuclein, CHLORIDE ION | | 著者 | Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R. | | 登録日 | 2024-07-03 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (2.23 Å) | | 主引用文献 | On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation.
Elife, 12, 2024
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