PDB: 127 件ウェブページステータス検索Chemie searchBIRD

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5KKN	Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630 分子名称: 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide, Acetyl-CoA carboxylase 2 著者 Wang, R, Paul, D, Tong, L. 登録日 2016-06-22 公開日 2016-07-13 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc.Natl.Acad.Sci.USA, 113, 2016
5DOU	Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 de Cima, S, Polo, L.M, Fita, I, Rubio, V. 登録日 2015-09-11 公開日 2015-12-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5, 2015
3JRW	Phosphorylated BC domain of ACC2 分子名称: Acetyl-CoA carboxylase 2 著者 Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S. 登録日 2009-09-09 公開日 2010-01-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK Biochem.Biophys.Res.Commun., 391, 2010
3VA7	Crystal structure of the Kluyveromyces lactis Urea Carboxylase 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, GLYCEROL, KLLA0E08119p, ... 著者 Fan, C, Xiang, S. 登録日 2011-12-29 公開日 2012-02-01 最終更新日 2013-07-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of urea carboxylase provides insights into the carboxyltransfer reaction J.Biol.Chem., 287, 2012
2VR1	Crystal structure of Biotin carboxylase from E. coli in complex with ATP analog, ADPCF2P. 分子名称: BIOTIN CARBOXYLASE, CHLORIDE ION, PHOSPHODIFLUOROMETHYLPHOSPHONIC ACID-ADENYLATE ESTER 著者 Mochalkin, I, Waldrop, G.L. 登録日 2008-03-24 公開日 2008-09-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase. Protein Sci., 17, 2008
6W2J	CPS1 bound to allosteric inhibitor H3B-374 分子名称: (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone, 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], ... 著者 Larsen, N.A, Nguyen, T.V. 登録日 2020-03-05 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1. Acs Med.Chem.Lett., 11, 2020
8GK8	R21A Staphylococcus aureus pyruvate carboxylase 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, COENZYME A, ... 著者 Laseke, A.J, St.Maurice, M. 登録日 2023-03-17 公開日 2023-08-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Allosteric Site at the Biotin Carboxylase Dimer Interface Mediates Activation and Inhibition in Staphylococcus aureus Pyruvate Carboxylase. Biochemistry, 62, 2023
8J7D	Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... 著者 Liu, D.S, Su, J.Y. 登録日 2023-04-27 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state To Be Published
8FXI	Cryo-EM structure of Stanieria sp. CphA2 in complex with ADPCP and 4x(beta-Asp-Arg) 分子名称: 1-[(4-aminopyrimidin-5-yl)amino]-2,5-anhydro-1-deoxy-6-O-[(S)-hydroxy{[(R)-hydroxy(phosphonomethyl)phosphoryl]oxy}phosphoryl]-D-allitol, 4x(beta-Asp-Arg), MAGNESIUM ION, ... 著者 Markus, L.M, Sharon, I, Strauss, M, Schmeing, T.M. 登録日 2023-01-24 公開日 2023-06-14 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structure and function of a hexameric cyanophycin synthetase 2. Protein Sci., 32, 2023
4HQ6	BC domain in the presence of citrate 分子名称: Acetyl-CoA carboxylase 2 著者 Heo, Y.S. 登録日 2012-10-25 公開日 2013-10-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Insights into the Regulation of ACC2 by Citrate Bull.Korean Chem.Soc., 34, 2013
3HBL	Crystal Structure of S. aureus Pyruvate Carboxylase T908A Mutant 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Tong, L, Yu, L.P.C. 登録日 2009-05-04 公開日 2009-06-30 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
8J4Z	Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... 著者 Liu, D.S, Su, J.Y. 登録日 2023-04-21 公開日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.73 Å) 主引用文献 Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate To Be Published
8FXH	Cryo-EM structure of Stanieria sp. CphA2 分子名称: RimK domain-containing protein ATP-grasp 著者 Markus, L.M, Sharon, I, Strauss, M, Schmeing, T.M. 登録日 2023-01-24 公開日 2023-06-14 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structure and function of a hexameric cyanophycin synthetase 2. Protein Sci., 32, 2023
4HNV	Crystal structure of R54E mutant of S. aureus Pyruvate carboxylase 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Yu, L.P.C, Tong, L. 登録日 2012-10-21 公開日 2013-01-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis. Biochemistry, 52, 2013
4HNT	crystal structure of F403A mutant of S. aureus Pyruvate carboxylase 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Yu, L.P.C, Tong, L. 登録日 2012-10-21 公開日 2013-01-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis. Biochemistry, 52, 2013
2GPS	Crystal Structure of the Biotin Carboxylase Subunit, E23R mutant, of Acetyl-CoA Carboxylase from Escherichia coli. 分子名称: Biotin carboxylase 著者 Shen, Y, Chou, C.Y, Chang, G.G, Tong, L. 登録日 2006-04-18 公開日 2006-07-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Is dimerization required for the catalytic activity of bacterial biotin carboxylase? Mol.Cell, 22, 2006
3BG5	Crystal Structure of Staphylococcus Aureus Pyruvate Carboxylase 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Xiang, S, Tong, L. 登録日 2007-11-26 公開日 2008-02-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nat.Struct.Mol.Biol., 15, 2008
8J99	Human 3-methylcrotonyl-CoA carboxylase in BCS-mcoa state 分子名称: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, Methylcrotonoyl-CoA carboxylase subunit alpha, ... 著者 Liu, D.S, Su, J.Y. 登録日 2023-05-02 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Human 3-methylcrotonyl-CoA carboxylase in BCS-mcoa state To Be Published
3U9T	Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, free enzyme 分子名称: Methylcrotonyl-CoA carboxylase, alpha-subunit, beta-subunit 著者 Huang, C.S, Tong, L. 登録日 2011-10-19 公開日 2011-12-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase Nature, 481, 2012
3HB9	Crystal Structure of S. aureus Pyruvate Carboxylase A610T Mutant 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Tong, L, Yu, L.P.C. 登録日 2009-05-04 公開日 2009-06-30 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
3HO8	Crystal Structure of S. aureus Pyruvate Carboxylase in complex with Coenzyme A 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, MANGANESE (II) ION, ... 著者 Tong, L, Yu, L.P.C. 登録日 2009-06-01 公開日 2009-06-30 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
7TA5	Crystal structure of cyanophycin synthetase 2 from Gloeothece citriformis 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BICINE, D(-)-TARTARIC ACID, ... 著者 Sharon, I, Schmeing, T.M. 登録日 2021-12-20 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure and Function of the beta-Asp-Arg Polymerase Cyanophycin Synthetase 2. Acs Chem.Biol., 17, 2022
8HZ5	The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus 分子名称: Biotin carboxylase 著者 Shen, J, Wu, W, Xu, X. 登録日 2023-01-08 公開日 2024-01-10 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus To be published
4HNU	crystal structure of K442E mutant of S. aureus Pyruvate carboxylase 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Yu, L.P.C, Tong, L. 登録日 2012-10-21 公開日 2013-01-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis. Biochemistry, 52, 2013
5KS8	Crystal structure of two-subunit pyruvate carboxylase from Methylobacillus flagellatus 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, MANGANESE (II) ION, PYRUVIC ACID, ... 著者 Choi, P.H, Tong, L. 登録日 2016-07-07 公開日 2016-10-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 A distinct holoenzyme organization for two-subunit pyruvate carboxylase. Nat Commun, 7, 2016

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