Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7YGN
DownloadVisualize
BU of 7ygn by Molmil
Cryo-EM structure of the Mili in complex with piRNA
分子名称: MAGNESIUM ION, Piwi-like protein 2, piRNA
著者Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z.
登録日2022-07-11
公開日2024-01-24
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing.
Nat.Struct.Mol.Biol., 2024
2F8S
DownloadVisualize
BU of 2f8s by Molmil
Crystal structure of Aa-Ago with externally-bound siRNA
分子名称: 5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*AP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3', Argonaute protein
著者Yuan, Y.R, Chen, H.Y, Patel, D.J.
登録日2005-12-03
公開日2006-10-31
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA.
Structure, 14, 2006
3HJF
DownloadVisualize
BU of 3hjf by Molmil
Crystal structure of T. thermophilus Argonaute E546 mutant protein complexed with DNA guide strand and 15-nt RNA target strand
分子名称: 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ...
著者Wang, Y, Li, H, Sheng, G, Patel, D.J.
登録日2009-05-21
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.056 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
5XP8
DownloadVisualize
BU of 5xp8 by Molmil
Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 4A5 on the guide strand
分子名称: DNA (5'-D(*AP*GP*T)-3'), DNA (5'-D(*CP*AP*AP*CP*C*AP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*TP*GP*AP*GP*AP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), ...
著者Sheng, G, Gogakos, T, Wang, J, Zhao, H, Serganov, A, Juranek, S, Tuschl, T, Patel, J.D, Wang, Y.
登録日2017-06-01
公開日2018-04-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
3HXM
DownloadVisualize
BU of 3hxm by Molmil
Structure of an argonaute complexed with guide DNA and target RNA duplex containing two mismatches.
分子名称: Argonaute, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), MAGNESIUM ION, ...
著者Wang, Y, Li, H, Sheng, G, Patel, D.J.
登録日2009-06-21
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
2F8T
DownloadVisualize
BU of 2f8t by Molmil
Crystal structure of Aa-Ago with externally-bound siRNA
分子名称: 26-MER, Argonaute protein
著者Yuan, Y.R, Chen, H.Y, Patel, D.J.
登録日2005-12-03
公開日2006-10-31
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA.
Structure, 14, 2006
4W5Q
DownloadVisualize
BU of 4w5q by Molmil
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8
分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ...
著者Schirle, N.T, MacRae, I.J.
登録日2014-08-18
公開日2014-11-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.101 Å)
主引用文献Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
5WEA
DownloadVisualize
BU of 5wea by Molmil
Human Argonaute2 Helix-7 Mutant
分子名称: PHENOL, Protein argonaute-2, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*U)-3')
著者Schirle, N.T, Klum, S.M, MacRae, I.J.
登録日2017-07-08
公開日2017-11-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.12 Å)
主引用文献Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition.
EMBO J., 37, 2018
4F1N
DownloadVisualize
BU of 4f1n by Molmil
Crystal structure of Kluyveromyces polysporus Argonaute with a guide RNA
分子名称: KpAGO, RNA 5'-R(P*UP*AP*AP*AP*AP*AP*AP*AP*A)-3'
著者Nakanishi, K, Weinberg, D.E, Bartel, D.P, Patel, D.J.
登録日2012-05-07
公開日2012-06-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.187 Å)
主引用文献Structure of yeast Argonaute with guide RNA.
Nature, 486, 2012
2NUB
DownloadVisualize
BU of 2nub by Molmil
Structure of Aquifex aeolicus Argonuate
分子名称: Argonaute
著者Rashid, U.J, Paterok, D, Koglin, A, Gohlke, H, Piehler, J, Chen, J.C.-H.
登録日2006-11-09
公開日2007-02-06
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function.
J.Biol.Chem., 282, 2007
7YG6
DownloadVisualize
BU of 7yg6 by Molmil
Cryo-EM structure of the EfPiwi(N959K) in complex with piRNA
分子名称: MAGNESIUM ION, Piwi, piRNA
著者Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z.
登録日2022-07-11
公開日2024-01-24
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing.
Nat.Struct.Mol.Biol., 2024
7YFQ
DownloadVisualize
BU of 7yfq by Molmil
Cryo-EM structure of the EfPiwi (N959K)-piRNA-target ternary complex
分子名称: MAGNESIUM ION, Piwi, RNA (5'-R(*UP*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*AP*A)-3'), ...
著者Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z.
登録日2022-07-08
公開日2024-02-14
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing.
Nat.Struct.Mol.Biol., 2024
3HVR
DownloadVisualize
BU of 3hvr by Molmil
Crystal structure of T. thermophilus Argonaute complexed with DNA guide strand and 19-nt RNA target strand with two Mg2+ at the cleavage site
分子名称: 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*TP*GP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ...
著者Wang, Y, Li, H, Sheng, G, Patel, D.J.
登録日2009-06-16
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.211 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
7SVA
DownloadVisualize
BU of 7sva by Molmil
Cryo-EM structure of Arabidopsis Ago10-guide RNA complex
分子名称: MAGNESIUM ION, Protein argonaute 10, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3')
著者Xiao, Y, MacRae, I.J.
登録日2021-11-18
公開日2022-11-23
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Structural basis for RNA slicing by a plant Argonaute.
Nat.Struct.Mol.Biol., 30, 2023
5VM9
DownloadVisualize
BU of 5vm9 by Molmil
Human Argonaute3 bound to guide RNA
分子名称: Protein argonaute-3, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*UP*U)-3'), RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*UP*U)-3')
著者Park, M.S, Nakanishi, K.
登録日2017-04-26
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.28 Å)
主引用文献Human Argonaute3 has slicer activity.
Nucleic Acids Res., 45, 2017
3HM9
DownloadVisualize
BU of 3hm9 by Molmil
Crystal structure of T. thermophilus Argonaute complexed with DNA guide strand and 19-nt RNA target strand
分子名称: 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ...
著者Wang, Y, Li, H, Sheng, G, Patel, D.J.
登録日2009-05-28
公開日2009-10-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
5XQ2
DownloadVisualize
BU of 5xq2 by Molmil
Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 5A6 on the guide strand
分子名称: DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(*AP*GP*T)-3'), DNA (5'-D(P*TP*GP*AP*AP*GP*AP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), ...
著者Sheng, G, Gogakos, T, Wang, J, Zhao, H, Serganov, A, Juranek, S, Tuschl, T, Patel, D, Wang, Y.
登録日2017-06-06
公開日2017-10-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.33 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
6MDZ
DownloadVisualize
BU of 6mdz by Molmil
Human Argonaute2-miR-122 bound to a target RNA with two central mismatches (bu2)
分子名称: PHENOL, Protein argonaute-2, RNA (5'-R(P*AP*AP*AP*CP*AP*CP*CP*AP*UP*UP*UP*CP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), ...
著者Sheu-Gruttadauria, J, MacRae, I.J.
登録日2018-09-05
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural Basis for Target-Directed MicroRNA Degradation.
Mol.Cell, 75, 2019
7YFX
DownloadVisualize
BU of 7yfx by Molmil
Cryo-EM structure of Hili in complex with piRNA
分子名称: MAGNESIUM ION, Piwi-like protein 2, piRNA
著者Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z.
登録日2022-07-09
公開日2024-01-24
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing.
Nat.Struct.Mol.Biol., 2024
7YFY
DownloadVisualize
BU of 7yfy by Molmil
Cryo-EM structure of the Mili-piRNA- target ternary complex
分子名称: MAGNESIUM ION, Piwi-like protein 2, RNA (5'-R(P*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*AP*A)-3'), ...
著者Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z.
登録日2022-07-09
公開日2024-01-24
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing.
Nat.Struct.Mol.Biol., 2024
8QG0
DownloadVisualize
BU of 8qg0 by Molmil
Archaeoglobus fulgidus AfAgo complex with AfAgo-N protein (fAfAgo) bound with 17 nt RNA guide and 17 nt DNA target
分子名称: AfAgo-N protein, DNA target 17 nt, Piwi protein, ...
著者Manakova, E.N, Zaremba, M, Pocevicuite, R, Golovinas, E, Zagorskaite, E, Silanskas, A.
登録日2023-09-05
公開日2024-01-24
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein.
Nucleic Acids Res., 52, 2024
7KX9
DownloadVisualize
BU of 7kx9 by Molmil
Cryo-EM structure of Ephydatia fluviatilis PiwiA-piRNA-target complex
分子名称: MAGNESIUM ION, Piwi-A, RNA (5'-R(P*UP*CP*UP*CP*UP*UP*GP*AP*GP*UP*UP*GP*GP*AP*CP*AP*AP*AP*UP*GP*GP*CP*AP*(OMG))-3'), ...
著者Anzelon, T.A, Chowdhury, S, Lander, G.C, MacRae, I.J.
登録日2020-12-03
公開日2021-07-14
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis for piRNA targeting.
Nature, 597, 2021
6MFR
DownloadVisualize
BU of 6mfr by Molmil
Human Argonaute2-miR-122 bound to a target RNA with three central mismatches (bu3)
分子名称: PHENOL, PHOSPHATE ION, Protein argonaute-2, ...
著者Sheu-Gruttadauria, J, MacRae, I.J.
登録日2018-09-12
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural Basis for Target-Directed MicroRNA Degradation.
Mol.Cell, 75, 2019
2YHB
DownloadVisualize
BU of 2yhb by Molmil
Crystal Structure of the N. crassa QDE-2 AGO MID-PIWI Domains
分子名称: GLYCEROL, POST-TRANSCRIPTIONAL GENE SILENCING PROTEIN QDE-2, SULFATE ION
著者Boland, A, Weichenrieder, O.
登録日2011-04-27
公開日2011-06-15
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.65 Å)
主引用文献Crystal Structure of the Mid-Piwi Lobe of a Eukaryotic Argonaute Protein
Proc.Natl.Acad.Sci.USA, 108, 2011
7SWQ
DownloadVisualize
BU of 7swq by Molmil
Cryo-EM structure of Arabidopsis Ago10-guide-target RNA complex in a bent duplex conformation
分子名称: MAGNESIUM ION, Protein argonaute 10, RNA (5'-R(P*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), ...
著者Xiao, Y, MacRae, I.J.
登録日2021-11-21
公開日2022-11-23
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.79 Å)
主引用文献Structural basis for RNA slicing by a plant Argonaute.
Nat.Struct.Mol.Biol., 30, 2023

221051

件を2024-06-12に公開中

PDB statisticsPDBj update infoContact PDBjnumon