7YGN
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![BU of 7ygn by Molmil](/molmil-images/mine/7ygn) | Cryo-EM structure of the Mili in complex with piRNA | 分子名称: | MAGNESIUM ION, Piwi-like protein 2, piRNA | 著者 | Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. | 登録日 | 2022-07-11 | 公開日 | 2024-01-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024
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2F8S
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![BU of 2f8s by Molmil](/molmil-images/mine/2f8s) | Crystal structure of Aa-Ago with externally-bound siRNA | 分子名称: | 5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*AP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3', Argonaute protein | 著者 | Yuan, Y.R, Chen, H.Y, Patel, D.J. | 登録日 | 2005-12-03 | 公開日 | 2006-10-31 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA. Structure, 14, 2006
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3HJF
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![BU of 3hjf by Molmil](/molmil-images/mine/3hjf) | Crystal structure of T. thermophilus Argonaute E546 mutant protein complexed with DNA guide strand and 15-nt RNA target strand | 分子名称: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | 著者 | Wang, Y, Li, H, Sheng, G, Patel, D.J. | 登録日 | 2009-05-21 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.056 Å) | 主引用文献 | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
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5XP8
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![BU of 5xp8 by Molmil](/molmil-images/mine/5xp8) | Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 4A5 on the guide strand | 分子名称: | DNA (5'-D(*AP*GP*T)-3'), DNA (5'-D(*CP*AP*AP*CP*C*AP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*TP*GP*AP*GP*AP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), ... | 著者 | Sheng, G, Gogakos, T, Wang, J, Zhao, H, Serganov, A, Juranek, S, Tuschl, T, Patel, J.D, Wang, Y. | 登録日 | 2017-06-01 | 公開日 | 2018-04-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. Nucleic Acids Res., 45, 2017
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3HXM
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![BU of 3hxm by Molmil](/molmil-images/mine/3hxm) | Structure of an argonaute complexed with guide DNA and target RNA duplex containing two mismatches. | 分子名称: | Argonaute, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), MAGNESIUM ION, ... | 著者 | Wang, Y, Li, H, Sheng, G, Patel, D.J. | 登録日 | 2009-06-21 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
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2F8T
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![BU of 2f8t by Molmil](/molmil-images/mine/2f8t) | |
4W5Q
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![BU of 4w5q by Molmil](/molmil-images/mine/4w5q) | |
5WEA
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![BU of 5wea by Molmil](/molmil-images/mine/5wea) | Human Argonaute2 Helix-7 Mutant | 分子名称: | PHENOL, Protein argonaute-2, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*U)-3') | 著者 | Schirle, N.T, Klum, S.M, MacRae, I.J. | 登録日 | 2017-07-08 | 公開日 | 2017-11-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition. EMBO J., 37, 2018
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4F1N
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![BU of 4f1n by Molmil](/molmil-images/mine/4f1n) | Crystal structure of Kluyveromyces polysporus Argonaute with a guide RNA | 分子名称: | KpAGO, RNA 5'-R(P*UP*AP*AP*AP*AP*AP*AP*AP*A)-3' | 著者 | Nakanishi, K, Weinberg, D.E, Bartel, D.P, Patel, D.J. | 登録日 | 2012-05-07 | 公開日 | 2012-06-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.187 Å) | 主引用文献 | Structure of yeast Argonaute with guide RNA. Nature, 486, 2012
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2NUB
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![BU of 2nub by Molmil](/molmil-images/mine/2nub) | Structure of Aquifex aeolicus Argonuate | 分子名称: | Argonaute | 著者 | Rashid, U.J, Paterok, D, Koglin, A, Gohlke, H, Piehler, J, Chen, J.C.-H. | 登録日 | 2006-11-09 | 公開日 | 2007-02-06 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function. J.Biol.Chem., 282, 2007
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7YG6
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![BU of 7yg6 by Molmil](/molmil-images/mine/7yg6) | Cryo-EM structure of the EfPiwi(N959K) in complex with piRNA | 分子名称: | MAGNESIUM ION, Piwi, piRNA | 著者 | Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. | 登録日 | 2022-07-11 | 公開日 | 2024-01-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024
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7YFQ
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![BU of 7yfq by Molmil](/molmil-images/mine/7yfq) | Cryo-EM structure of the EfPiwi (N959K)-piRNA-target ternary complex | 分子名称: | MAGNESIUM ION, Piwi, RNA (5'-R(*UP*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*AP*A)-3'), ... | 著者 | Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. | 登録日 | 2022-07-08 | 公開日 | 2024-02-14 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024
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3HVR
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![BU of 3hvr by Molmil](/molmil-images/mine/3hvr) | Crystal structure of T. thermophilus Argonaute complexed with DNA guide strand and 19-nt RNA target strand with two Mg2+ at the cleavage site | 分子名称: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*TP*GP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | 著者 | Wang, Y, Li, H, Sheng, G, Patel, D.J. | 登録日 | 2009-06-16 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.211 Å) | 主引用文献 | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
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7SVA
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![BU of 7sva by Molmil](/molmil-images/mine/7sva) | |
5VM9
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![BU of 5vm9 by Molmil](/molmil-images/mine/5vm9) | Human Argonaute3 bound to guide RNA | 分子名称: | Protein argonaute-3, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*UP*U)-3'), RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*UP*U)-3') | 著者 | Park, M.S, Nakanishi, K. | 登録日 | 2017-04-26 | 公開日 | 2017-10-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.28 Å) | 主引用文献 | Human Argonaute3 has slicer activity. Nucleic Acids Res., 45, 2017
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3HM9
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![BU of 3hm9 by Molmil](/molmil-images/mine/3hm9) | Crystal structure of T. thermophilus Argonaute complexed with DNA guide strand and 19-nt RNA target strand | 分子名称: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | 著者 | Wang, Y, Li, H, Sheng, G, Patel, D.J. | 登録日 | 2009-05-28 | 公開日 | 2009-10-06 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
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5XQ2
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![BU of 5xq2 by Molmil](/molmil-images/mine/5xq2) | Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 5A6 on the guide strand | 分子名称: | DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(*AP*GP*T)-3'), DNA (5'-D(P*TP*GP*AP*AP*GP*AP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), ... | 著者 | Sheng, G, Gogakos, T, Wang, J, Zhao, H, Serganov, A, Juranek, S, Tuschl, T, Patel, D, Wang, Y. | 登録日 | 2017-06-06 | 公開日 | 2017-10-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | 主引用文献 | Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes Nucleic Acids Res., 45, 2017
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6MDZ
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![BU of 6mdz by Molmil](/molmil-images/mine/6mdz) | |
7YFX
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![BU of 7yfx by Molmil](/molmil-images/mine/7yfx) | Cryo-EM structure of Hili in complex with piRNA | 分子名称: | MAGNESIUM ION, Piwi-like protein 2, piRNA | 著者 | Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. | 登録日 | 2022-07-09 | 公開日 | 2024-01-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024
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7YFY
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![BU of 7yfy by Molmil](/molmil-images/mine/7yfy) | Cryo-EM structure of the Mili-piRNA- target ternary complex | 分子名称: | MAGNESIUM ION, Piwi-like protein 2, RNA (5'-R(P*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*AP*A)-3'), ... | 著者 | Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. | 登録日 | 2022-07-09 | 公開日 | 2024-01-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024
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8QG0
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![BU of 8qg0 by Molmil](/molmil-images/mine/8qg0) | Archaeoglobus fulgidus AfAgo complex with AfAgo-N protein (fAfAgo) bound with 17 nt RNA guide and 17 nt DNA target | 分子名称: | AfAgo-N protein, DNA target 17 nt, Piwi protein, ... | 著者 | Manakova, E.N, Zaremba, M, Pocevicuite, R, Golovinas, E, Zagorskaite, E, Silanskas, A. | 登録日 | 2023-09-05 | 公開日 | 2024-01-24 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein. Nucleic Acids Res., 52, 2024
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7KX9
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![BU of 7kx9 by Molmil](/molmil-images/mine/7kx9) | Cryo-EM structure of Ephydatia fluviatilis PiwiA-piRNA-target complex | 分子名称: | MAGNESIUM ION, Piwi-A, RNA (5'-R(P*UP*CP*UP*CP*UP*UP*GP*AP*GP*UP*UP*GP*GP*AP*CP*AP*AP*AP*UP*GP*GP*CP*AP*(OMG))-3'), ... | 著者 | Anzelon, T.A, Chowdhury, S, Lander, G.C, MacRae, I.J. | 登録日 | 2020-12-03 | 公開日 | 2021-07-14 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis for piRNA targeting. Nature, 597, 2021
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6MFR
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![BU of 6mfr by Molmil](/molmil-images/mine/6mfr) | |
2YHB
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![BU of 2yhb by Molmil](/molmil-images/mine/2yhb) | |
7SWQ
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![BU of 7swq by Molmil](/molmil-images/mine/7swq) | |