PDB: 250 件ウェブページステータス検索Chemie searchBIRD

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3MP8	Crystal structure of Sgf29 tudor domain 分子名称: 4-(HYDROXYMETHYL)BENZAMIDINE, ACETIC ACID, GLYCEROL, ... 著者 Li, J, Wu, M, Ruan, J, Zang, J. 登録日 2010-04-26 公開日 2011-05-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation Embo J., 30, 2011
3MEW	Crystal structure of Novel Tudor domain-containing protein SGF29 分子名称: SAGA-associated factor 29 homolog 著者 Xu, C, Bian, C.B, Lam, R, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2010-03-31 公開日 2010-04-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. Embo J., 30, 2011
3SOW	Structure of UHRF1 PHD finger in complex with histone H3K4me3 1-9 peptide 分子名称: E3 ubiquitin-protein ligase UHRF1, Histone H3, ZINC ION 著者 Rajakumara, E, Patel, D.J. 登録日 2011-06-30 公開日 2011-08-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9501 Å) 主引用文献 PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression. Mol.Cell, 43, 2011
5WLE	Crystal structure of the PPS PHD finger in complex with H3K4me3 分子名称: H3K4me3 Peptide, Protein partner of snf, isoform A, ... 著者 Klein, B.J, Kutateladze, T.G. 登録日 2017-07-26 公開日 2017-10-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.952 Å) 主引用文献 A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO. Structure, 25, 2017
4HSU	Crystal structure of LSD2-NPAC with H3(1-26)in space group P21 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3, Lysine-specific histone demethylase 1B, ... 著者 Chen, F, Dong, Z, Fang, J, Xu, Y. 登録日 2012-10-30 公開日 2013-02-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.988 Å) 主引用文献 Structural insight into substrate recognition by histone demethylase LSD2/KDM1b. Cell Res., 23, 2013
5D6W	Crystal structure of double tudor domain of human lysine demethylase KDM4A 分子名称: Lysine-specific demethylase 4A, S,R MESO-TARTARIC ACID 著者 Wang, F, Su, Z, Denu, J.M, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2015-08-13 公開日 2015-11-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.992 Å) 主引用文献 Reader domain specificity and lysine demethylase-4 family function. Nat Commun, 7, 2016
4GUT	Crystal structure of LSD2-NPAC 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1B, ... 著者 Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. 登録日 2012-08-29 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
3QZV	Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide 分子名称: Histone H4, Nucleosome-remodeling factor subunit BPTF, ZINC ION 著者 Li, H, Ruthenburg, A.J, Patel, D.J. 登録日 2011-03-07 公開日 2011-06-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
3LPY	Crystal structure of the RRM domain of CyP33 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Peptidyl-prolyl cis-trans isomerase E, SULFATE ION 著者 Wang, Z, Patel, D.J. 登録日 2010-02-07 公開日 2010-07-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
2G6Q	Crystal structure of ING2 PHD finger in complex with H3K4Me3 peptide 分子名称: H3K4Me3 peptide, Inhibitor of growth protein 2, ZINC ION 著者 Pena, P.V, Zhao, R, Kutateladze, T.G. 登録日 2006-02-24 公開日 2006-07-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature, 442, 2006
5A1H	Crystal structure of human Spindlin3 分子名称: SPINDLIN-3 著者 Srikannathasan, V, Gileadi, C, Johansson, C, Shrestha, L, Tallon, R, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U. 登録日 2015-04-30 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Human Spindlin3 To be Published
3MET	Crystal structure of SGF29 in complex with H3K4me2 分子名称: GLYCEROL, Histone H3, SAGA-associated factor 29 homolog, ... 著者 Bian, C.B, Xu, C, Lam, R, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2010-03-31 公開日 2010-04-28 最終更新日 2011-08-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. Embo J., 30, 2011
5A3N	Crystal structure of human PLU-1 (JARID1B) in complex with KDOAM25a 分子名称: 1,2-ETHANEDIOL, 2-[[[2-[2-(dimethylamino)ethyl-ethyl-amino]-2-oxidanylidene-ethyl]amino]methyl]pyridine-4-carboxamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Srikannathasan, V, Johansson, C, Gileadi, C, Nuzzi, A, Ruda, G.F, Kopec, J, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Brennan, P, Oppermann, U. 登録日 2015-06-02 公開日 2015-07-08 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol, 24, 2017
5A3W	Crystal structure of human PLU-1 (JARID1B) in complex with Pyridine-2, 6-dicarboxylic Acid (PDCA) 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, LYSINE-SPECIFIC DEMETHYLASE 5B, ... 著者 Srikannathasan, V, Johansson, C, Gileadi, C, Kopec, J, Strain-Damerell, C, Kupinska, K, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Oppermann, U. 登録日 2015-06-03 公開日 2015-06-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
2V85	Crystal structure of RAG2-PHD finger in complex with H3R2me1K4me3 peptide 分子名称: H3R2ME1K4ME3 PEPTIDE, VDJ RECOMBINATION-ACTIVATING PROTEIN 2, ZINC ION 著者 Ramon-Maiques, S, Yang, W. 登録日 2007-08-02 公開日 2007-12-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Plant Homeodomain Finger of Rag2 Recognizes Histone H3 Methylated at Both Lysine-4 and Arginine-2. Proc.Natl.Acad.Sci.USA, 104, 2007
2V88	Crystal structure of RAG2-PHD finger in complex with H3R2me2sK4me2 peptide 分子名称: H3R2ME2SK4ME3 PEPTIDE, VDJ RECOMBINATION-ACTIVATING PROTEIN 2, ZINC ION 著者 Ramon-Maiques, S, Yang, W. 登録日 2007-08-03 公開日 2007-12-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Plant Homeodomain Finger of Rag2 Recognizes Histone H3 Methylated at Both Lysine-4 and Arginine-2. Proc.Natl.Acad.Sci.USA, 104, 2007
2F6N	Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the free form 分子名称: ZINC ION, bromodomain PHD finger transcription factor 著者 Li, H, Patel, D.J. 登録日 2005-11-29 公開日 2006-07-11 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature, 442, 2006
2F6J	Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the H3(1-15)K4me3 bound state 分子名称: ZINC ION, bromodomain PHD finger transcription factor, histone H3, ... 著者 Li, H, Patel, D.J. 登録日 2005-11-29 公開日 2006-07-11 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature, 442, 2006
5Z8L	crystal structure of Arabidopsis thaliana EBS in complex with an H3K27me3 peptide 分子名称: Chromatin remodeling protein EBS, H3K27me3 peptide, ZINC ION 著者 Yang, Z, Du, J. 登録日 2018-01-31 公開日 2018-07-25 最終更新日 2018-09-19 実験手法 X-RAY DIFFRACTION (2.005 Å) 主引用文献 EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis. Nat. Genet., 50, 2018
5A3P	Crystal structure of the catalytic domain of human PLU1 (JARID1B). 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, LYSINE-SPECIFIC DEMETHYLASE 5B, ... 著者 Nowak, R, Srikannathasan, V, Johansson, C, Gileadi, C, Tallant, C, Kupinska, K, Strain-Damerell, C, Szykowska, A, von Delft, F, Burgess-Brown, N.A, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Oppermann, U. 登録日 2015-06-02 公開日 2015-06-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.008 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
2V86	Crystal structure of RAG2-PHD finger in complex with H3R2me2aK4me3 peptide 分子名称: H3R2ME2AK4ME3 PEPTIDE, VDJ RECOMBINATION-ACTIVATING PROTEIN 2, ZINC ION 著者 Ramon-Maiques, S, Yang, W. 登録日 2007-08-02 公開日 2007-12-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The Plant Homeodomain Finger of Rag2 Recognizes Histone H3 Methylated at Both Lysine-4 and Arginine-2. Proc.Natl.Acad.Sci.USA, 104, 2007
7XE2	Crystal structure of LSD2 in complex with trans-4-Br-PCPA 分子名称: 3-(4-bromophenyl)propanal, CITRATE ANION, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Niwa, H, Sato, S, Umehara, T. 登録日 2022-03-29 公開日 2022-09-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 Acs Med.Chem.Lett., 13, 2022
5F32	Crystal structure of human KDM4A in complex with compound 40 分子名称: 1,2-ETHANEDIOL, 8-(2-azanyl-1,3-thiazol-4-yl)-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... 著者 Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
6LUK	Crystal structure of the SAMD1 SAM domain in another crystal form 分子名称: Atherin, SULFATE ION 著者 Cao, Y, Zhou, Y, Wang, Z. 登録日 2020-01-29 公開日 2021-02-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.054 Å) 主引用文献 The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
5F3C	Crystal structure of human KDM4A in complex with compound 52d 分子名称: 8-[4-[2-[(4-fluorophenyl)methyl-methyl-amino]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Le Bihan, Y.-V, Westwood, I.M, van Montfort, R.L.M. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016

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