7ZGO
 
 | | Cryo-EM structure of human NKCC1 (TM domain) | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Nissen, P, Fenton, R, Neumann, C, Lindtoft Rosenbaek, L, Kock Flygaard, R, Habeck, M, Lykkegaard Karlsen, J, Wang, Y, Lindorff-Larsen, K, Gad, H, Hartmann, R, Lyons, J. | | 登録日 | 2022-04-04 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | | 主引用文献 | Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.
Embo J., 41, 2022
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8RIY
 | | Human NUDT5 with ibrutinib derivative | | 分子名称: | 1-(1-methylpiperidin-4-yl)-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine, ADP-sugar pyrophosphatase | | 著者 | Balikci-Akil, E, Elkins, J.M, Huber, K.V.M. | | 登録日 | 2023-12-19 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.288 Å) | | 主引用文献 | Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.
J.Med.Chem., 67, 2024
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6WC9
 | | Human open state TMEM175 in KCl | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | 著者 | Oh, S, Paknejad, N, Hite, R.K. | | 登録日 | 2020-03-30 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
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3KDP
 | | Crystal structure of the sodium-potassium pump | | 分子名称: | CHOLESTEROL, MAGNESIUM ION, Na+/K+ ATPase gamma subunit transcript variant a, ... | | 著者 | Morth, J.P, Pedersen, B.P, Nissen, P. | | 登録日 | 2009-10-23 | | 公開日 | 2010-02-16 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Crystal structure of the sodium-potassium pump.
Nature, 450, 2007
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7MKE
 | | Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2) | | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Saecker, R.M, Darst, S.A, Chen, J. | | 登録日 | 2021-04-23 | | 公開日 | 2021-09-29 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7MKI
 | | Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR (-5G to C) promoter DNA | | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Saecker, R.M, Darst, S.A, Chen, J. | | 登録日 | 2021-04-23 | | 公開日 | 2021-09-29 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6WOV
 | | Cryo-EM structure of recombinant mouse Ryanodine Receptor type 2 wild type in complex with FKBP12.6 | | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION | | 著者 | Iyer, K.A, Hu, Y, Nayak, A.R, Kurebayashi, N, Murayama, T, Samso, M. | | 登録日 | 2020-04-25 | | 公開日 | 2020-08-05 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | | 主引用文献 | Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM.
Sci Adv, 6, 2020
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4H9R
 | | Complex structure 5 of DAXX(E225A)/H3.3(sub5,G90A)/H4 | | 分子名称: | Death domain-associated protein 6, Histone H3.3, Histone H4, ... | | 著者 | Elsasser, S.J, Huang, H, Lewis, P.W, Chin, J.W, Allis, D.C, Patel, D.J. | | 登録日 | 2012-09-24 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.197 Å) | | 主引用文献 | DAXX chaperone envelops an H3.3/H4 dimer dictating H3.3-specific read out
To be Published
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4H9O
 | | Complex structure 2 of DAXX/H3.3(sub5,G90M)/H4 | | 分子名称: | Death domain-associated protein 6, Histone H3.3, Histone H4, ... | | 著者 | Elsasser, S.J, Huang, H, Lewis, P.W, Chin, J.W, Allis, D.C, Patel, D.J. | | 登録日 | 2012-09-24 | | 公開日 | 2012-10-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | | 主引用文献 | DAXX chaperone envelops an H3.3/H4 dimer dictating H3.3-specific read out
To be Published
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5XXQ
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5Y1U
 | | Crystal structure of RBBP4 bound to AEBP2 RRK motif | | 分子名称: | Histone-binding protein RBBP4, SULFATE ION, Zinc finger protein AEBP2 | | 著者 | Sun, A, Li, F, Wu, J, Shi, Y. | | 登録日 | 2017-07-21 | | 公開日 | 2018-04-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.141 Å) | | 主引用文献 | Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4
Protein Cell, 2017
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4PL5
 | | Crystal structure of murine IRE1 in complex with OICR573 inhibitor | | 分子名称: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 3-methoxy-5-methyl-4'-(morpholin-4-yl)biphenyl-4-ol, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Sanches, M, Duffy, N, Talukdar, M, Thevakumaran, N, Chiovitti, D, Al-awar, R, Patterson, J.B, Sicheri, F. | | 登録日 | 2014-05-16 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Nat Commun, 5, 2014
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6TRD
 | | Cryo- EM structure of the Thermosynechococcus elongatus photosystem I in the presence of cytochrome c6 | | 分子名称: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | | 著者 | Koelsch, A, Radon, C, Baumert, A, Buerger, J, Mielke, T, Lisdat, F, Zouni, A, Wendler, P. | | 登録日 | 2019-12-18 | | 公開日 | 2020-09-16 | | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | | 主引用文献 | Current limits of structural biology: The transient interaction between cytochrome c6 and photosystem I
Curr.Opin.Struct.Biol., 2, 2020
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3MI2
 | | Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate | | 分子名称: | (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-5-O-phosphono-D-ribitol, Uridine 5'-monophosphate synthase | | 著者 | Liu, Y, To, T, Kotra, L.P, Pai, E.F. | | 登録日 | 2010-04-09 | | 公開日 | 2010-05-26 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase.
Bioorg.Med.Chem., 18, 2010
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7NSY
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7NSZ
 | | Drosophila PGRP-LB Y78F mutant | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Isoform A of Peptidoglycan-recognition protein LB, SODIUM ION, ... | | 著者 | Orlans, J, Aller, P, Da Silva, P. | | 登録日 | 2021-03-08 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction.
Int J Mol Sci, 22, 2021
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7NSX
 | | Drosophila PGRP-LB wild-type | | 分子名称: | Isoform A of Peptidoglycan-recognition protein LB, ZINC ION | | 著者 | Orlans, J, Aller, P, Da Silva, P. | | 登録日 | 2021-03-08 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction.
Int J Mol Sci, 22, 2021
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7NT0
 | | Drosophila PGRP-LB Y78F mutant in complex with tracheal cytotoxin (TCT) | | 分子名称: | GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA, Isoform A of Peptidoglycan-recognition protein LB, ZINC ION | | 著者 | Orlans, J, Aller, P, Da Silva, P. | | 登録日 | 2021-03-08 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction.
Int J Mol Sci, 22, 2021
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6TBA
 | | Virion of native gene transfer agent (GTA) particle | | 分子名称: | IRON/SULFUR CLUSTER, Phage major capsid protein, HK97 family, ... | | 著者 | Bardy, P, Fuzik, T, Hrebik, D, Pantucek, R, Beatty, J.T, Plevka, P. | | 登録日 | 2019-11-01 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.54 Å) | | 主引用文献 | Structure and mechanism of DNA delivery of a gene transfer agent.
Nat Commun, 11, 2020
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4MZZ
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4H9Q
 | | Complex structure 4 of DAXX(E225A)/H3.3(sub5)/H4 | | 分子名称: | Death domain-associated protein 6, Histone H3.3, Histone H4, ... | | 著者 | Elsasser, S.J, Huang, H, Lewis, P.W, Chin, J.W, Allis, D.C, Patel, D.J. | | 登録日 | 2012-09-24 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | DAXX chaperone envelops an H3.3/H4 dimer dictating H3.3-specific read out
To be Published
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4MPL
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4JL6
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4JLO
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4P0M
 | | Crystal structure of an evolved putative penicillin-binding protein homolog, Rv2911, from Mycobacterium tuberculosis | | 分子名称: | D-alanyl-D-alanine carboxypeptidase | | 著者 | Krieger, I, Yu, M, Bursey, E, Hung, L.-W, Terwilliger, T.C, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2014-02-21 | | 公開日 | 2014-03-12 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Subfamily-Specific Adaptations in the Structures of Two Penicillin-Binding Proteins from Mycobacterium tuberculosis.
Plos One, 9, 2014
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