4I51
| Methyltransferase domain of HUMAN EUCHROMATIC HISTONE METHYLTRANSFERASE 1, mutant Y1211A | 分子名称: | GLYCEROL, H3K9 NE-ALLYL PEPTIDE, Histone-lysine N-methyltransferase EHMT1, ... | 著者 | Dong, A, Zeng, H, Walker, J.R, Islam, K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Lou, M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2012-11-28 | 公開日 | 2012-12-19 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
4I5P
| Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain | 分子名称: | (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-(1H-pyrrol-2-yl)-7,8-dihydropteridin-6(5H)-one, Serine/threonine-protein kinase PLK2 | 著者 | Aubele, D.L, Hom, R.K, Adler, M, Galemmo Jr, R.A, Bowers, S, Truong, A.P, Pan, H, Beroza, P. | 登録日 | 2012-11-28 | 公開日 | 2013-12-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.738 Å) | 主引用文献 | Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain. Chemmedchem, 8, 2013
|
|
4KRC
| Crystal Structure of Pho85-Pcl10-ATP-gamma-S Complex | 分子名称: | Cyclin-dependent protein kinase PHO85, MAGNESIUM ION, PHO85 cyclin-10, ... | 著者 | Quiocho, F.A, Zheng, F. | 登録日 | 2013-05-16 | 公開日 | 2013-09-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.597 Å) | 主引用文献 | New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition. J.Biol.Chem., 288, 2013
|
|
4K99
| Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppdG(2 ,5 )pdG | 分子名称: | 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, 3'-deoxy-guanosine 5'-monophosphate, Cyclic GMP-AMP synthase, ... | 著者 | Gao, P, Wu, Y, Patel, D.J. | 登録日 | 2013-04-19 | 公開日 | 2013-05-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153, 2013
|
|
4MC0
| Hedycaryol apo | 分子名称: | Putative sesquiterpene cyclase | 著者 | Baer, P, Rabe, P, Cirton, C, Oliveira Mann, C, Kaufmann, N, Groll, M, Dickschat, J. | 登録日 | 2013-08-21 | 公開日 | 2014-01-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism. Chembiochem, 15, 2014
|
|
4P6F
| |
4L02
| Crystal Structure of SphK1 with inhibitor | 分子名称: | (2R,4S)-1-[2-(4-{[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]amino}phenyl)ethyl]-2-(hydroxymethyl)piperidin-4-ol, Sphingosine kinase 1 | 著者 | Min, X, Walker, N, Wang, Z. | 登録日 | 2013-05-30 | 公開日 | 2013-07-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
|
|
4PFC
| Crystal structure of insulin degrading enzyme complexed with inhibitor | 分子名称: | Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate | 著者 | Wang, Y, Guo, S. | 登録日 | 2014-04-28 | 公開日 | 2015-06-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem., 290, 2015
|
|
4L27
| Crystal structure of delta1-39 and delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag | 分子名称: | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE | 著者 | Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A. | 登録日 | 2013-06-04 | 公開日 | 2013-09-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.391 Å) | 主引用文献 | Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
4L3V
| Crystal structure of delta516-525 human cystathionine beta-synthase | 分子名称: | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE | 著者 | Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A. | 登録日 | 2013-06-07 | 公開日 | 2013-09-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.628 Å) | 主引用文献 | Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
4L7V
| Crystal structure of Protein L-isoaspartyl-O-methyltransferase of Vibrio cholerae | 分子名称: | ACETATE ION, CALCIUM ION, Protein-L-isoaspartate O-methyltransferase, ... | 著者 | Chatterjee, T, Mukherjee, D, Chakrabarti, P. | 登録日 | 2013-06-14 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal structure and activity of protein L-isoaspartyl-O-methyltransferase from Vibrio cholerae, and the effect of AdoHcy binding. Arch.Biochem.Biophys., 583, 2015
|
|
4L28
| Crystal structure of delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag | 分子名称: | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE | 著者 | Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A. | 登録日 | 2013-06-04 | 公開日 | 2013-09-18 | 最終更新日 | 2013-10-16 | 実験手法 | X-RAY DIFFRACTION (2.626 Å) | 主引用文献 | Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
3MOY
| |
2M8J
| Structure of Pin1 WW domain phospho-mimic S16E | 分子名称: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Luh, L.M, Kirchner, D.K, Loehr, F, Haensel, R, Doetsch, V. | 登録日 | 2013-05-22 | 公開日 | 2014-04-09 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition. J.Am.Chem.Soc., 135, 2013
|
|
5DU6
| Crystal structure of M. tuberculosis EchA6 bound to ligand GSK059A. | 分子名称: | (5R,7R)-5-(4-ethylphenyl)-N-(4-fluorobenzyl)-7-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, Probable enoyl-CoA hydratase echA6 | 著者 | Cox, J.A.G, Besra, G.S, Futterer, K. | 登録日 | 2015-09-18 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Nat Microbiol, 1, 2016
|
|
2M0X
| |
4X4N
| |
4X4W
| |
3MDF
| Crystal structure of the RRM domain of Cyclophilin 33 | 分子名称: | Peptidyl-prolyl cis-trans isomerase E | 著者 | Hom, R.A, Chang, P.Y, Roy, S, Mussleman, C.A, Glass, K.C, Seleznevia, A.I, Gozani, O, Ismagilov, R.F, Cleary, M.L, Kutateladze, T.G. | 登録日 | 2010-03-30 | 公開日 | 2010-05-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J.Mol.Biol., 400, 2010
|
|
4XDP
| Crystal structure of human KDM4C catalytic domain bound to tris | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | 著者 | Swinger, K.K, Boriack-Sjodin, P.A. | 登録日 | 2014-12-19 | 公開日 | 2015-03-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening. J Biomol Screen, 20, 2015
|
|
4D7Q
| Crystal structure of a chimeric protein with the Sec7 domain of Legionella pneumophila RalF and the capping domain of Rickettsia prowazekii RalF | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Folly-Klan, M, Sancerne, B, Alix, E, Roy, C.R, Cherfils, J, Campanacci, V. | 登録日 | 2014-11-27 | 公開日 | 2015-01-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | On the Use of Legionella/Rickettsia Chimeras to Investigate the Structure and Regulation of Rickettsia Effector Ralf. J.Struct.Biol., 189, 2015
|
|
3EE0
| Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1)) | 分子名称: | Thrombin heavy chain, Thrombin light chain | 著者 | Gandhi, P.S, Page, M.J, Chen, Z, Bush-Pelc, L, Di Cera, E. | 登録日 | 2008-09-03 | 公開日 | 2009-07-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Molecular Basis for the Kinetic Differences of the W215A/E217A Mutant of Human and Murine Thrombin To be Published
|
|
5ERN
| |
4DZ0
| |
5EOY
| Pseudomonas aeruginosa SeMet-PilM bound to ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Type 4 fimbrial biogenesis protein PilM | 著者 | McCallum, M, Tammam, S, Robinson, H, Shah, M, Calmettes, C, Moraes, T, Burrows, L.L, Howell, P.L. | 登録日 | 2015-11-10 | 公開日 | 2016-04-27 | 最終更新日 | 2016-06-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM. J.Biol.Chem., 291, 2016
|
|