4AGV
| Structure of a tetrameric galectin from Cinachyrella sp. (Ball sponge) | 分子名称: | GALECTIN | 著者 | Freymann, D.M, Focia, P.J, Sakai, R, Swanson, G.T. | 登録日 | 2012-01-31 | 公開日 | 2012-08-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure of a Tetrameric Galectin from Cinachyrella Sp. (Ball Sponge). Acta Crystallogr.,Sect.D, 68, 2012
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1XD1
| Acarbose Rearrangement Mechanism Implied by the Kinetic and Structural Analysis of Human Pancreatic alpha-Amylase in Complex with Analogues and Their Elongated Counterparts | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACARBOSE DERIVED HEXASACCHARIDE, Alpha-amylase, ... | 著者 | Li, C, Begum, A, Numao, S, Park, K.H, Withers, S.G, Brayer, G.D. | 登録日 | 2004-09-03 | 公開日 | 2004-12-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Acarbose Rearrangement Mechanism Implied by the Kinetic and Structural Analysis of Human Pancreatic alpha-Amylase in Complex with Analogues and Their Elongated Counterparts Biochemistry, 44, 2005
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4H3F
| Structure of BACE Bound to 3-(5-((7aR)-2-imino-6-(6-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1H-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile | 分子名称: | 3-{5-[(2E,4aR,7aR)-2-imino-6-(6-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-7aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl}benzonitrile, Beta-secretase 1, L(+)-TARTARIC ACID | 著者 | Strickland, C, Mandal, M. | 登録日 | 2012-09-13 | 公開日 | 2012-11-07 | 最終更新日 | 2012-11-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation. J.Med.Chem., 55, 2012
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6VA2
| Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MH5 | 分子名称: | (2E,2'E)-2,2'-{dibenzo[b,d]thiene-2,8-diyldi[(1E)eth-1-yl-1-ylidene]}bis(N-methylhydrazine-1-carboximidamide), RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3'), RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3') | 著者 | Chen, J.L, Fountain, M.A, Disney, M.D. | 登録日 | 2019-12-16 | 公開日 | 2020-05-20 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. J.Am.Chem.Soc., 142, 2020
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1OGQ
| The crystal structure of PGIP (polygalacturonase inhibiting protein), a leucine rich repeat protein involved in plant defense | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, POLYGALACTURONASE INHIBITING PROTEIN | 著者 | Di Matteo, A, Federici, L, Mattei, B, Salvi, G, Johnson, K.A, Savino, C, De Lorenzo, G, Tsernoglou, D, Cervone, F. | 登録日 | 2003-05-08 | 公開日 | 2003-07-24 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Crystal Structure of Polygalacturonase-Inhibiting Protein (Pgip), a Leucine-Rich Repeat Protein Involved in Plant Defense Proc.Natl.Acad.Sci.USA, 100, 2003
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4BSJ
| Crystal structure of VEGFR-3 extracellular domains D4-5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3 | 著者 | Leppanen, V.-M, Tvorogov, D, Kisko, K, Prota, A.E, Jeltsch, M, Anisimov, A, Markovic-Mueller, S, Stuttfeld, E, Goldie, K.N, Ballmer-Hofer, K, Alitalo, K. | 登録日 | 2013-06-10 | 公開日 | 2013-07-31 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and Mechanistic Insights Into Vegfr-3 Ligand Binding and Activation Proc.Natl.Acad.Sci.USA, 110, 2013
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3B9K
| Crystal structure of CD8alpha-beta in complex with YTS 156.7 FAB | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab Light Chain, ... | 著者 | Shore, D, Wilson, I.A. | 登録日 | 2007-11-05 | 公開日 | 2008-11-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The Crystal Structure of CD8 in Complex with YTS156.7.7 Fab and Interaction with Other CD8 Antibodies Define the Binding Mode of CD8 alphabeta to MHC Class I J.Mol.Biol., 384, 2008
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1YA4
| Crystal Structure of Human Liver Carboxylesterase 1 in complex with tamoxifen | 分子名称: | (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CES1 protein, ... | 著者 | Fleming, C.D, Bencharit, S, Edwards, C.C, Hyatt, J.L, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R. | 登録日 | 2004-12-17 | 公開日 | 2005-08-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J.Mol.Biol., 352, 2005
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1YBW
| Protease domain of HGFA with no inhibitor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hepatocyte growth factor activator precursor | 著者 | Shia, S, Stamos, J, Kirchhofer, D, Fan, B, Wu, J, Corpuz, R.T, Santell, L, Lazarus, R.A, Eigenbrot, C. | 登録日 | 2004-12-21 | 公開日 | 2005-02-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. J.Mol.Biol., 346, 2005
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3R0Z
| Crystal structure of apo D-serine deaminase from Salmonella typhimurium | 分子名称: | 1,2-ETHANEDIOL, D-serine dehydratase, SULFATE ION | 著者 | Bharath, S.R, Shveta, B, Savithri, H.S, Murthy, M.R.N. | 登録日 | 2011-03-09 | 公開日 | 2011-06-29 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structures of open and closed forms of D-serine deaminase from Salmonella typhimurium - implications on substrate specificity and catalysis Febs J., 2011
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4H1E
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1ZBW
| Crystal structure of the complex formed between signalling protein from goat mammary gland (SPG-40) and a tripeptide Trp-Pro-Trp at 2.8A resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase-3 like protein 1, WPW | 著者 | Kumar, J, Ethayathulla, A.S, Srivastava, D.B, Singh, N, Sharma, S, Somvanshi, R.K, Dey, S, Singh, T.P. | 登録日 | 2005-04-09 | 公開日 | 2005-04-26 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the complex formed between signalling protein from goat mammary gland (SPG-40) and a tripeptide Trp-Pro-Trp at 2.8A resolution to be published
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3BXX
| Binding of two substrate analogue molecules to dihydroflavonol 4-reductase alters the functional geometry of the catalytic site | 分子名称: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, dihydroflavonol 4-reductase | 著者 | Trabelsi, N, Petit, P, Granier, T, Langlois d'Estaintot, B, Delrot, S, Gallois, B. | 登録日 | 2008-01-15 | 公開日 | 2008-10-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural evidence for the inhibition of grape dihydroflavonol 4-reductase by flavonols Acta Crystallogr.,Sect.D, D64, 2008
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1ZF2
| Four-stranded DNA Holliday Junction (CCC) | 分子名称: | 5'-D(*CP*CP*GP*GP*GP*CP*CP*CP*GP*G)-3' | 著者 | Hays, F.A, Teegarden, A.T, Jones, Z.J.R, Harms, M, Raup, D, Watson, J, Cavaliere, E, Ho, P.S. | 登録日 | 2005-04-19 | 公開日 | 2005-05-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | How sequence defines structure: a crystallographic map of DNA structure and conformation. Proc.Natl.Acad.Sci.Usa, 102, 2005
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1VTJ
| MOLECULAR STRUCTURE OF THE NETROPSIN-D(CGCGATATCGCG) COMPLEX: DNA CONFORMATION IN AN ALTERNATING AT SEGMENT; CONFORMATION 1 | 分子名称: | DNA (5'-D(*CP*GP*CP*GP*AP*TP*AP*TP*CP*GP*CP*G)-3'), NETROPSIN | 著者 | Coll, M, Aymami, J, Van Der Marel, G.A, Van Boom, J.H, Rich, A, Wang, A.H.-J. | 登録日 | 1999-09-14 | 公開日 | 2011-07-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular Structure of the Netropsin-d(CGCGATATCGCG) Complex: DNA Conformation in an Alternating AT Segment Biochemistry, 28, 1989
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1YYL
| crystal structure of CD4M33, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CD4M33, scorpion-toxin mimic of CD4, ... | 著者 | Huang, C.C, Stricher, F, Martin, L, Decker, J.M, Majeed, S, Barthe, P, Hendrickson, W.A, Robinson, J, Roumestand, C, Sodroski, J, Wyatt, R, Shaw, G.M, Vita, C, Kwong, P.D. | 登録日 | 2005-02-25 | 公開日 | 2005-05-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth. Structure, 13, 2005
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2F7R
| Golgi alpha-mannosidase II complex with benzyl-aminocyclopentitetrol | 分子名称: | (1R,2R,3S,4S,5R)-5-(BENZYLAMINO)CYCLOPENTANE-1,2,3,4-TETROL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Rose, D.R. | 登録日 | 2005-12-01 | 公開日 | 2006-12-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Golgi alpha-mannosidase II complex with benzyl-aminocyclopentitetrol To be Published
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1ZBA
| Foot-and-Mouth Disease virus serotype A1061 complexed with oligosaccharide receptor. | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Coat protein VP1, Coat protein VP2, ... | 著者 | Fry, E.E, Newman, J.W, Curry, S, Najjam, S, Jackson, T, Blakemore, W, Lea, S.M, Miller, L, Burman, A, King, A.M, Stuart, D.I. | 登録日 | 2005-04-08 | 公開日 | 2005-06-28 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of Foot-and-mouth disease virus serotype A1061 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation. J.Gen.Virol., 86, 2005
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1GOE
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2CHH
| RALSTONIA SOLANACEARUM HIGH-AFFINITY MANNOSE-BINDING LECTIN | 分子名称: | CALCIUM ION, PROTEIN RSC3288, UNKNOWN ATOM OR ION, ... | 著者 | Mitchell, E.P, Wimmerova, M, Imberty, A. | 登録日 | 2006-03-15 | 公開日 | 2006-03-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | A new Ralstonia solanacearum high-affinity mannose-binding lectin RS-IIL structurally resembling the Pseudomonas aeruginosa fucose-specific lectin PA-IIL. Mol. Microbiol., 52, 2004
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2HRR
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2A2T
| crystal structure of d(AAATATTT) | 分子名称: | 5'-D(*AP*AP*AP*TP*AP*TP*TP*T)-3', CACODYLATE ION, MANGANESE (II) ION | 著者 | Valls, N, Richter, M, Subirana, J.A. | 登録日 | 2005-06-23 | 公開日 | 2005-11-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of a DNA duplex with all-AT base pairs. Acta Crystallogr.,Sect.D, 61, 2005
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4HCT
| Crystal structure of ITK in complex with compound 52 | 分子名称: | 3-{1-[(3R)-1-acryloylpiperidin-3-yl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-(3-tert-butylphenyl)benzamide, Tyrosine-protein kinase ITK/TSK | 著者 | Zapf, C.W, Gerstenberger, B.S, Xing, L, Limburg, D.C, Anderson, D.R, Caspers, N, Han, S, Aulabaugh, A, Kurumbail, R, Shakya, S, Li, X, Spaulding, V, Czerwinski, R.M, Seth, N, Medley, Q.G. | 登録日 | 2012-10-01 | 公開日 | 2012-11-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Covalent inhibitors of interleukin-2 inducible T cell kinase (itk) with nanomolar potency in a whole-blood assay. J.Med.Chem., 55, 2012
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1OC1
| ISOPENICILLIN N SYNTHASE aminoadipoyl-cysteinyl-aminobutyrate-FE COMPLEX | 分子名称: | DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VINYLGLYCINE, FE (II) ION, ISOPENICILLIN N SYNTHETASE, ... | 著者 | Long, A.J, Clifton, I.J, Roach, P.L, Baldwin, J.E, Schofield, C.J, Rutledge, P.J. | 登録日 | 2003-02-03 | 公開日 | 2004-02-02 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Studies on the Reaction of Isopenicillin N Synthase with the Substrate Analogue Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D-Alpha-Aminobutyrate Biochem.J., 372, 2003
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3BWJ
| Complex of PKA with the bisubstrate protein kinase inhibitor lead compound Arc-1034 | 分子名称: | (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-(6-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}butyl]amino}-6-oxohexyl)-3,4-dihydroxytetrahydrofuran-2-carboxamide, cAMP-dependent protein kinase, alpha-catalytic subunit | 著者 | Lavogina, D, Koenig, N, Uri, A, Bossemeyer, D. | 登録日 | 2008-01-09 | 公開日 | 2009-02-03 | 最終更新日 | 2019-09-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases. J.Med.Chem., 52, 2009
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