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6PFV
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Structure of S. venezuelae RisG-WhiG-c-di-GMP complex: orthorhombic crystal form
分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), AmfC protein, RNA polymerase sigma factor
著者Schumacher, M.A.
登録日2019-06-22
公開日2019-11-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献c-di-GMP Arms an Anti-sigma to Control Progression of Multicellular Differentiation in Streptomyces.
Mol.Cell, 77, 2020
1TI7
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BU of 1ti7 by Molmil
CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR, IN COMPLEX WITH NADP AT 1.7A RESOLUTION
分子名称: CHLORIDE ION, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Lamb, H.K, Leslie, K, Dodds, A.L, Nutley, M, Cooper, A, Johnson, C, Thompson, P, Stammers, D.K, Hawkins, A.R.
登録日2004-06-02
公開日2004-06-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides.
J.Biol.Chem., 278, 2003
6I7V
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BU of 6i7v by Molmil
Ribosomal protein paralogs bL31 and bL36
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ...
著者Pulk, A, Cate, J.H.D, Remme, J, Lilleorg, S, Reier, K, Peil, L, Liiv, A, Tammsalu, T.
登録日2018-11-19
公開日2018-12-05
最終更新日2024-04-24
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Bacterial ribosome heterogeneity: Changes in ribosomal protein composition during transition into stationary growth phase.
Biochimie, 156, 2018
8D4U
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BU of 8d4u by Molmil
Crystal Structure of Neutrophil Elastase Inhibited by Eap2 from S. aureus
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular Adherence Protein, ...
著者Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
登録日2022-06-02
公開日2022-12-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family.
J.Biol.Chem., 299, 2023
8D4Q
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BU of 8d4q by Molmil
Crystal Structure of Neutrophil Elastase Inhibited by Eap1 from S. aureus
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular Adherence Protein, Neutrophil elastase
著者Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
登録日2022-06-02
公開日2022-12-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family.
J.Biol.Chem., 299, 2023
8B0V
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BU of 8b0v by Molmil
Crystal structure of C-terminal domain of Pseudomonas aeruginosa LexA G91D mutant
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
著者Vascon, F, De Felice, S, Chinellato, M, Maso, L, Cendron, L.
登録日2022-09-08
公開日2024-03-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural investigations on the SOS response in Pseudomonas aeruginosa
To Be Published
8C7O
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BU of 8c7o by Molmil
Unliganded transcriptional pleiotropic repressor CodY from Staphylococcus aureus
分子名称: ACETATE ION, Global transcriptional regulator CodY, SULFATE ION
著者Hainzl, T, Sauer-Eriksson, A.E.
登録日2023-01-16
公開日2023-06-28
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural insights into CodY activation and DNA recognition.
Nucleic Acids Res., 51, 2023
8C7S
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BU of 8c7s by Molmil
Transcriptional pleiotropic repressor CodY from Staphylococcus aureus in complex with Ile, GTP, and a 30-bp DNA fragment encompassing two overlapping binding sites
分子名称: DNA (30-MER), GUANOSINE-5'-TRIPHOSPHATE, Global transcriptional regulator CodY (Fragment), ...
著者Hainzl, T, Sauer-Eriksson, A.E.
登録日2023-01-17
公開日2023-07-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Structural insights into CodY activation and DNA recognition.
Nucleic Acids Res., 51, 2023
6T9M
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BU of 6t9m by Molmil
Crystal structure of the Chitinase Domain of the Spore Coat Protein CotE from Clostridium difficile
分子名称: DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, Peptide in active site, ...
著者Whittingham, J.L, Dodson, E.J, Wilkinson, A.J.
登録日2019-10-28
公開日2020-07-22
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystal structures of the GH18 domain of the bifunctional peroxiredoxin-chitinase CotE from Clostridium difficile.
Acta Crystallogr.,Sect.F, 76, 2020
8TZX
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BU of 8tzx by Molmil
Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1
分子名称: (3S)-3-(5-{(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione, 1,2-ETHANEDIOL, DNA damage-binding protein 1, ...
著者Clifton, M.C, Ma, X, Ornelas, E.
登録日2023-08-28
公開日2024-07-10
最終更新日2024-07-17
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
Science, 385, 2024
2IJI
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BU of 2iji by Molmil
Structure of F14H mutant of ColE1 Rom protein
分子名称: Regulatory protein rop
著者Struble, E.B.
登録日2006-09-29
公開日2007-10-16
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献New crystal structures of ColE1 Rom and variants resulting from mutation of a surface exposed residue: Implications for RNA-recognition.
Proteins, 72, 2008
7TDP
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BU of 7tdp by Molmil
Structure of Paenibacillus polymyxa GS bound to Met-Sox-P-ADP (Transition state complex) to 1.98 Angstom
分子名称: ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ...
著者Schumacher, M.A.
登録日2022-01-02
公開日2022-06-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
Nat Commun, 13, 2022
7TDV
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BU of 7tdv by Molmil
Crystal structure of S. aureus glutamine synthetase in Met-Sox-P/ADP transition state complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ...
著者Schumacher, M.A.
登録日2022-01-03
公開日2022-06-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
Nat Commun, 13, 2022
7TEN
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BU of 7ten by Molmil
Crystal structure of the Listeria monocytogenes GS-Met-Sox-P- ADP complex to 3.5 Angstrom
分子名称: ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase, L-METHIONINE-S-SULFOXIMINE PHOSPHATE
著者Schumacher, M.A.
登録日2022-01-05
公開日2022-06-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
Nat Commun, 13, 2022
6HL0
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BU of 6hl0 by Molmil
Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide
分子名称: Bile acid receptor, NCoA-2 peptide (Nuclear receptor coactivator 2), LYS-GLU-ASN-ALA-LEU-LEU-ARG-TYR-LEU-LEU-ASP-LYS-ASP
著者Kudlinzki, D, Merk, D, Linhard, V.L, Saxena, K, Schubert-Zsilavecz, M, Schwalbe, H.
登録日2018-09-10
公開日2019-05-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Molecular tuning of farnesoid X receptor partial agonism.
Nat Commun, 10, 2019
6HL1
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BU of 6hl1 by Molmil
Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide and CDCA
分子名称: Bile acid receptor, CHENODEOXYCHOLIC ACID, NCoA-2 peptide (Nuclear receptor coactivator 2), ...
著者Kudlinzki, D, Merk, D, Linhard, V.L, Saxena, K, Schubert-Zsilavecz, M, Schwalbe, H.
登録日2018-09-10
公開日2019-05-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Molecular tuning of farnesoid X receptor partial agonism.
Nat Commun, 10, 2019
6CDA
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BU of 6cda by Molmil
Crystal structure of L34A CzrA in the Zn(II)bound state
分子名称: ArsR family transcriptional regulator, CHLORIDE ION, GLYCEROL, ...
著者Capdevila, D.A, Gonzalez-Gutierrez, G, Giedroc, D.P.
登録日2018-02-08
公開日2018-07-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Functional Role of Solvent Entropy and Conformational Entropy of Metal Binding in a Dynamically Driven Allosteric System.
J. Am. Chem. Soc., 140, 2018
4RQW
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BU of 4rqw by Molmil
Crystal structure of Myc3 N-terminal JAZ-binding domain [44-238] from Arabidopsis
分子名称: CALCIUM ION, Transcription factor MYC3
著者Ke, J, Zhang, F, Zhou, X.E, Brunzelle, J, Zhou, M, Xu, H.E, Melcher, K, He, S.Y.
登録日2014-11-05
公開日2015-08-12
最終更新日2015-09-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
Nature, 525, 2015
6E69
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BU of 6e69 by Molmil
Ortho-substituted phenyl sulfonyl fluoride and fluorosulfate as potent elastase inhibitory fragments
分子名称: 2-(fluorosulfonyl)benzene-1-sulfonic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wolan, D.W, Woehl, J.L, Kitamura, S.
登録日2018-07-24
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.
Proc.Natl.Acad.Sci.USA, 116, 2019
6F5M
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BU of 6f5m by Molmil
Crystal structure of highly glycosylated human leukocyte elastase in complex with a thiazolidinedione inhibitor
分子名称: 5-[[4-[[(2~{S})-4-methyl-1-oxidanylidene-1-[(2-propylphenyl)amino]pentan-2-yl]carbamoyl]phenyl]methyl]-2-oxidanylidene-1,3-thiazol-1-ium-4-olate, ACETATE ION, Neutrophil elastase, ...
著者Hochscherf, J, Pietsch, M, Tieu, W, Kuan, K, Hautmann, S, Abell, A, Guetschow, M, Niefind, K.
登録日2017-12-01
公開日2018-08-08
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6J9C
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BU of 6j9c by Molmil
Crystal structure of Arabidopsis thaliana transcription factor LEC2-DNA complex
分子名称: B3 domain-containing transcription factor LEC2, DNA (5'-D(*CP*AP*AP*TP*CP*CP*AP*TP*GP*CP*AP*GP*AP*AP*T)-3'), DNA (5'-D(*GP*AP*TP*TP*CP*TP*GP*CP*AP*TP*GP*GP*AP*TP*T)-3')
著者Hu, H, Du, J.
登録日2019-01-22
公開日2019-05-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.102 Å)
主引用文献Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis.
Nat.Plants, 5, 2019
3E2Q
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Crystal Structure Reduced PutA86-630 Mutant Y540S Complexed with trans-4-hydroxy-L-proline
分子名称: 4-HYDROXYPROLINE, FLAVIN-ADENINE DINUCLEOTIDE, PENTAETHYLENE GLYCOL, ...
著者Tanner, J.J.
登録日2008-08-06
公開日2009-02-03
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A conserved active site tyrosine residue of proline dehydrogenase helps enforce the preference for proline over hydroxyproline as the substrate.
Biochemistry, 48, 2009
3E2S
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BU of 3e2s by Molmil
Crystal Structure Reduced PutA86-630 Mutant Y540S Complexed with L-proline
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, PENTAETHYLENE GLYCOL, PROLINE, ...
著者Tanner, J.J.
登録日2008-08-06
公開日2009-02-03
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A conserved active site tyrosine residue of proline dehydrogenase helps enforce the preference for proline over hydroxyproline as the substrate.
Biochemistry, 48, 2009
3E2R
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Crystal Structure PutA86-630 Mutant Y540S Complexed with L-tetrahydro-2-furoic acid
分子名称: CITRIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, PENTAETHYLENE GLYCOL, ...
著者Tanner, J.J.
登録日2008-08-06
公開日2009-02-03
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献A conserved active site tyrosine residue of proline dehydrogenase helps enforce the preference for proline over hydroxyproline as the substrate.
Biochemistry, 48, 2009
3EPZ
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BU of 3epz by Molmil
Structure of the replication foci-targeting sequence of human DNA cytosine methyltransferase DNMT1
分子名称: DNA (cytosine-5)-methyltransferase 1, GLYCEROL, SODIUM ION, ...
著者Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2008-09-30
公開日2008-11-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.
J.Biol.Chem., 286, 2011

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