PDB: 19228 件ウェブページステータス検索Chemie searchBIRD

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6G9N	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: (2~{R})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(3-methylphenyl)-2-oxidanyl-ethyl]propanamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2018-04-11 公開日 2018-05-30 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
6GAW	Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. This file contains the complete 55S ribosome. 分子名称: 12S ribosomal RNA, mitochondrial, 16S ribosomal RNA, ... 著者 Kummer, E, Leibundgut, M, Boehringer, D, Ban, N. 登録日 2018-04-13 公開日 2018-08-22 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. Nature, 560, 2018
5VYT	Crystal structure of the WbkC N-formyltransferase (F142A variant) from Brucella melitensis 分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Gdp-mannose 4,6-dehydratase / gdp-4-amino-4,6-dideoxy-d-mannose formyltransferase, ... 著者 Riegert, A.S, Chantigian, D.P, Thoden, J.B, Holden, H.M. 登録日 2017-05-26 公開日 2017-07-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis. Biochemistry, 56, 2017
8CSR	Human mitochondrial small subunit assembly intermediate (State C) 分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... 著者 Harper, N.J, Burnside, C, Klinge, S. 登録日 2022-05-13 公開日 2022-12-14 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (2.54 Å) 主引用文献 Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
8CSS	Human mitochondrial small subunit assembly intermediate (State D) 分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... 著者 Harper, N.J, Burnside, C, Klinge, S. 登録日 2022-05-13 公開日 2022-12-14 最終更新日 2023-02-08 実験手法 ELECTRON MICROSCOPY (2.36 Å) 主引用文献 Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
5W13	ADC-7 in complex with boronic acid transition state inhibitor SM23 分子名称: (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID, Beta-lactamase 著者 Smolen, K.A, Powers, R.A, Wallar, B.J. 登録日 2017-06-01 公開日 2017-11-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel beta-Lactamase Inhibitors. ACS Infect Dis, 4, 2018
8CSQ	Human mitochondrial small subunit assembly intermediate (State B) 分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... 著者 Harper, N.J, Burnside, C, Klinge, S. 登録日 2022-05-13 公開日 2022-12-14 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.54 Å) 主引用文献 Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
5LZA	Structure of the 70S ribosome with SECIS-mRNA and P-site tRNA (Initial complex, IC) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Fischer, N, Neumann, P, Bock, L.V, Maracci, C, Wang, Z, Paleskava, A, Konevega, A.L, Schroeder, G.F, Grubmueller, H, Ficner, R, Rodnina, M.V, Stark, H. 登録日 2016-09-29 公開日 2016-11-23 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature, 540, 2016
8CSP	Human mitochondrial small subunit assembly intermediate (State A) 分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... 著者 Harper, N.J, Burnside, C, Klinge, S. 登録日 2022-05-13 公開日 2022-12-14 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.66 Å) 主引用文献 Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
5W12	ADC-7 in complex with boronic acid transition state inhibitor EC04 分子名称: 3-[(2R)-2-borono-2-{[(thiophen-2-yl)acetyl]amino}ethyl]benzoic acid, Beta-lactamase 著者 Smolen, K.A, Powers, R.A, Wallar, B.J. 登録日 2017-06-01 公開日 2017-11-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel beta-Lactamase Inhibitors. ACS Infect Dis, 4, 2018
8CSU	Human mitochondrial small subunit assembly intermediate (State C*) 分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... 著者 Harper, N.J, Burnside, C, Klinge, S. 登録日 2022-05-13 公開日 2022-12-14 最終更新日 2023-02-08 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
5VQP	Crystal structure of human pro-TGF-beta1 分子名称: Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A. 登録日 2017-05-09 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Prodomain-growth factor swapping in the structure of pro-TGF-beta 1. J. Biol. Chem., 293, 2018
6G8X	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: 4-chloranyl-1~{H}-indazol-3-amine, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2018-04-10 公開日 2018-05-30 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
8CST	Human mitochondrial small subunit assembly intermediate (State E) 分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... 著者 Harper, N.J, Burnside, C, Klinge, S. 登録日 2022-05-13 公開日 2022-12-14 最終更新日 2023-02-08 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
5LQZ	Structure of F-ATPase from Pichia angusta, state1 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase OSCP subunit, ... 著者 Vinothkumar, K.R, Montgomery, M.G, Liu, S, Walker, J.E. 登録日 2016-08-17 公開日 2016-11-16 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (7 Å) 主引用文献 Structure of the mitochondrial ATP synthase fromPichia angustadetermined by electron cryo-microscopy. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
6GED	Adhesin domain of PrgB from Enterococcus faecalis bound to DNA 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(P*CP*GP*GP*GP*CP*CP*GP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*CP*GP*GP*CP*CP*CP*G)-3'), ... 著者 Schmitt, A, Berntsson, R.P.A. 登録日 2018-04-26 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.794 Å) 主引用文献 PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction. Mol. Microbiol., 109, 2018
6FN5	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Gelin, M, Labesse, G. 登録日 2018-02-02 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.932 Å) 主引用文献 None To be published
6KN8	Structure of human cardiac thin filament in the calcium bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... 著者 Fujii, T, Yamada, Y, Namba, K. 登録日 2019-08-03 公開日 2020-01-15 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Cardiac muscle thin filament structures reveal calcium regulatory mechanism. Nat Commun, 11, 2020
6G0I	Active Fe-PP1 分子名称: FE (III) ION, MANGANESE (II) ION, PHOSPHATE ION, ... 著者 Salvi, F, Barabas, O, Koehn, M. 登録日 2018-03-18 公開日 2018-11-21 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Effects of stably incorporated iron on protein phosphatase-1 structure and activity. FEBS Lett., 592, 2018
5LZF	Structure of the 70S ribosome with fMetSec-tRNASec in the hybrid pre-translocation state (H) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Fischer, N, Neumann, P, Bock, L.V, Maracci, C, Wang, Z, Paleskava, A, Konevega, A.L, Schroeder, G.F, Grubmueller, H, Ficner, R, Rodnina, M.V, Stark, H. 登録日 2016-09-29 公開日 2016-11-23 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature, 540, 2016
5LX5	CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782-RP. 分子名称: DIPHOSPHATE, Nicotinamide phosphoribosyltransferase, [(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-5-[[[4-[6-(ethylamino)-5-(2-piperidin-1-ylethylcarbamoyl)pyridin-2-yl]-2-fluoranyl-phenyl]carbamoylamino]methyl]pyridin-1-ium-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate 著者 Bertrand, T, Marquette, J.P. 登録日 2016-09-20 公開日 2017-10-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782-RP To Be Published
5TZW	CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 1-[(3,4-difluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine 分子名称: MAGNESIUM ION, ZINC ION, [(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl](3,4-difluorophenyl)methanone, ... 著者 Xu, R, Aertgeerts, K. 登録日 2016-11-22 公開日 2017-02-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. J. Med. Chem., 60, 2017
5U78	Crystal structure of ORP8 PH domain in P1211 space group 分子名称: Oxysterol-binding protein-related protein 8 著者 Ghai, R, Yang, H. 登録日 2016-12-12 公開日 2017-10-18 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.978 Å) 主引用文献 ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane. Nat Commun, 8, 2017
5U8T	Structure of Eukaryotic CMG Helicase at a Replication Fork and Implications 分子名称: Cell division control protein 45, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA replication complex GINS protein PSF1, ... 著者 Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, Li, H, O'Donnell, M.E. 登録日 2016-12-15 公開日 2017-02-08 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6H1K	The major G-quadruplex form of HIV-1 LTR 分子名称: DNA (28-MER) 著者 Phan, A.T, Heddi, B, Butovskaya, E, Bakalar, B, Richter, S.N. 登録日 2018-07-11 公開日 2018-10-17 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Major G-Quadruplex Form of HIV-1 LTR Reveals a (3 + 1) Folding Topology Containing a Stem-Loop. J. Am. Chem. Soc., 140, 2018

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