PDB: 36840 件ウェブページステータス検索Chemie searchBIRD

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2HY8	PAK1 complex with ST2001 分子名称: (5S,6R,7R,9R)-12-HYDROXY-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[ B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE, Serine/threonine-protein kinase PAK 1 著者 Schulze-Gahmen, U, Lu, H. 登録日 2006-08-04 公開日 2006-11-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of the Complex Between Human Pak1-kinase and 3-Hydroxystaurosporine To be Published
2LNW	Identification and structural basis for a novel interaction between Vav2 and Arap3 分子名称: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, Guanine nucleotide exchange factor VAV2 著者 Wu, B, Zhang, J, Wu, J, Shi, Y. 登録日 2012-01-05 公開日 2012-11-21 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Identification and structural basis for a novel interaction between Vav2 and Arap3. J.Struct.Biol., 180, 2012
2HS2	Crystal structure of M46L mutant of HIV-1 protease complexed with TMC114 (darunavir) 分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Weber, I.T, Kovalevsky, A.Y, Liu, F. 登録日 2006-07-20 公開日 2006-10-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.22 Å) 主引用文献 Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114. J.Mol.Biol., 363, 2006
2I4Q	Human renin/PF02342674 complex 分子名称: (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE, Renin 著者 Holsworth, D.D, Jalaie, M, Zhang, E, Mcconnell, P, Mochalkin, I, Finzel, B.C. 登録日 2006-08-22 公開日 2006-10-24 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors. Bioorg.Med.Chem., 15, 2007
2LFJ	Solution structure of the monomeric derivative of BS-RNase 分子名称: Seminal ribonuclease 著者 Spadaccini, R, Picone, D. 登録日 2011-07-06 公開日 2012-02-08 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 NMR Studies on Structure and Dynamics of the Monomeric Derivative of BS-RNase: New Insights for 3D Domain Swapping. Plos One, 7, 2012
2L33	Solution NMR Structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E 分子名称: Interleukin enhancer-binding factor 3 著者 Liu, G, Janjua, H, Xiao, R, Acton, T.B, Ciccosanti, A, Shastry, R.B, Everett, J, Montelione, G.T, Northeast Structural Genomics Consortium, Northeast Structural Genomics Consortium (NESG) 登録日 2010-09-03 公開日 2010-09-22 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Northeast Structural Genomics Consortium Target HR4527E To be Published
2I94	NMR Structure of recoverin bound to rhodopsin kinase 分子名称: CALCIUM ION, Recoverin, Rhodopsin kinase 著者 Ames, J.B. 登録日 2006-09-05 公開日 2006-10-10 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structural Basis for Calcium-induced Inhibition of Rhodopsin Kinase by Recoverin. J.Biol.Chem., 281, 2006
2L4Q	Solution Structures of Oxidized and Reduced Thioredoxin C from M. tb 分子名称: Thioredoxin 著者 Olson, A.L, Cai, S, Sem, D.S. 登録日 2010-10-12 公開日 2011-10-12 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structures of Mycobacterium tuberculosis thioredoxin C and models of intact thioredoxin system suggest new approaches to inhibitor and drug design. Proteins, 81, 2013
6Y0B	Crystal structure of the cAMP-dependent protein kinase A cocrystallized with quinazolin-4-amine and PKI (5-24) 分子名称: DIMETHYL SULFOXIDE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ... 著者 Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2020-02-07 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published
2LGP	Solution structure of LA45 from LDLR 分子名称: CALCIUM ION, Low-density lipoprotein receptor 著者 Guttman, M, Komives, E.A. 登録日 2011-08-01 公開日 2011-11-30 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 The Structure, Dynamics, and Binding of the LA45 Module Pair of the Low-Density Lipoprotein Receptor Suggest an Important Role for LA4 in Ligand Release. Biochemistry, 50, 2011
2LTS	Solution structure of RDE-4(150-235) 分子名称: Protein RDE-4 著者 Deshmukh, M, Chiliveri, S. 登録日 2012-05-31 公開日 2013-12-04 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structure of RDE-4 dsRBDs and mutational studies provide insights into dsRNA recognition in the Caenorhabditis elegans RNAi pathway. Biochem.J., 458, 2014
2HS1	Ultra-high resolution X-ray crystal structure of HIV-1 protease V32I mutant with TMC114 (darunavir) inhibitor 分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Weber, I.T, Kovalevsky, A.Y. 登録日 2006-07-20 公開日 2006-10-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (0.84 Å) 主引用文献 Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114. J.Mol.Biol., 363, 2006
2LTR	Solution structure of RDE-4(32-136) 分子名称: Protein RDE-4 著者 Deshmukh, M, Chiliveri, S. 登録日 2012-05-31 公開日 2013-12-04 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structure of RDE-4 dsRBDs and mutational studies provide insights into dsRNA recognition in the Caenorhabditis elegans RNAi pathway. Biochem.J., 458, 2014
2HZC	Crystal structure of the N-terminal RRM of the U2AF large subunit 分子名称: HEXAETHYLENE GLYCOL, Splicing factor U2AF 65 kDa subunit, ZINC ION 著者 Thickman, K.R, Sickmier, E.A, Kielkopf, C.L. 登録日 2006-08-08 公開日 2006-08-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Alternative Conformations at the RNA-binding Surface of the N-terminal U2AF(65) RNA Recognition Motif. J.Mol.Biol., 366, 2007
6Y05	Crystal structure of the cAMP-dependent protein kinase A cocrystallized with adenine and PKI (5-24) 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ADENINE, ... 著者 Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2020-02-06 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published
2HTX	Crystal Structure Analysis of Hen Egg White Lysozyme Crosslinked by Polymerized Glutaraldehyde in Acidic Environment 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C, ... 著者 Wine, Y, Cohen-Hadar, N, Freeman, A, Lagziel-Simis, S, Frolow, F. 登録日 2006-07-26 公開日 2007-05-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Elucidation of the mechanism and end products of glutaraldehyde crosslinking reaction by X-ray structure analysis Biotechnol.Bioeng., 98, 2007
2L7F	Solution Structure of the Pitx2 Homeodomain 分子名称: Pituitary homeobox 2 著者 Doerdelmann, T, Rance, M, Baird-Titus, J.M, Kojetin, D.J. 登録日 2010-12-08 公開日 2011-12-14 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution Structure of the Pitx2 Homeodomain To be Published
2HUB	Structure of Hen Egg-White Lysozyme Determined from crystals grown in pH 7.5 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, D(-)-TARTARIC ACID, ... 著者 Frolow, F, Lagziel-Simis, S, Cohen-Hadar, N, Wine, Y, Freeman, A. 登録日 2006-07-26 公開日 2007-07-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.201 Å) 主引用文献 Monitoring influence of pH on the molecular and crystal structure of hen egg-white tetragonal lysozyme To be Published
4IC8	Crystal structure of the apo ERK5 kinase domain 分子名称: Mitogen-activated protein kinase 7 著者 Gogl, G, Remenyi, A. 登録日 2012-12-10 公開日 2013-02-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module. J.Biol.Chem., 288, 2013
2LQD	Reduced and CO-bound cytochrome P450cam (CYP101A1) 分子名称: CARBON MONOXIDE, Camphor 5-monooxygenase, POTASSIUM ION, ... 著者 Pochapsky, T.C, Pochapsky, S.S, Asciutto, E, Madura, J, Young, M.J. 登録日 2012-03-02 公開日 2012-05-09 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution Structural Ensembles of Substrate-Free Cytochrome P450(cam). Biochemistry, 51, 2012
2LCS	Yeast Nbp2p SH3 domain in complex with a peptide from Ste20p 分子名称: NAP1-binding protein 2, Serine/threonine-protein kinase STE20 著者 Gorelik, M, Davidson, A.R. 登録日 2011-05-07 公開日 2012-02-01 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Distinct Peptide Binding Specificities of Src Homology 3 (SH3) Protein Domains Can Be Determined by Modulation of Local Energetics across the Binding Interface. J.Biol.Chem., 287, 2012
2HUP	Crystal structure of human RAB43 in complex with GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-related protein RAB-43, ... 著者 Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2006-07-27 公開日 2006-08-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structure of human RAB43 in complex with GDP To be Published
2HU0	N1 neuraminidase in complex with oseltamivir 1 分子名称: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, Neuraminidase 著者 Russell, R.J, Haire, L.F, Stevens, D.J, Collins, P.J, Lin, Y.P, Blackburn, G.M, Hay, A.J, Gamblin, S.J, Skehel, J.J. 登録日 2006-07-26 公開日 2006-09-05 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature, 443, 2006
2LPM	Chemical Shift and Structure Assignments for Sma0114 分子名称: Two-component response regulator 著者 Sheftic, S.R, Gage, D.J, Alexandrescu, A.T. 登録日 2012-02-15 公開日 2012-09-12 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Nuclear Magnetic Resonance Structure and Dynamics of the Response Regulator Sma0114 from Sinorhizobium meliloti. Biochemistry, 51, 2012
2HUW	X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand 分子名称: Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION 著者 Benfield, A.P, Martin, S.F. 登録日 2006-07-27 公開日 2006-08-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 45, 2006

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