PDB: 36840 件ウェブページステータス検索Chemie searchBIRD

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2LMJ	Itk-sh3 分子名称: Tyrosine-protein kinase ITK/TSK 著者 Kristiansen, P, Bie Andersen, T, Huszenicza, Z, Andreotti, A.H, Spurkland, A. 登録日 2011-12-05 公開日 2012-12-05 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 The SH3 domains of the Tec family kinase Itk and the Src family kinase Lck compete for adjacent sites on T-cell specific adapter protein To be Published
2HW7	Crystal Structure of Mnk2-D228G in complex with Staurosporine 分子名称: MAP kinase-interacting serine/threonine-protein kinase 2, STAUROSPORINE, ZINC ION 著者 Jauch, R, Wahl, M.C. 登録日 2006-08-01 公開日 2006-08-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment. Embo J., 25, 2006
2HSY	Solution structure of Thioredoxin 2 from Saccharomyces cerevisiae 分子名称: Thioredoxin II 著者 Amorim, G.C, Valente, A.P, Almeida, F.C.L. 登録日 2006-07-24 公開日 2007-03-20 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 NMR solution structure of the reduced form of thioredoxin 2 from Saccharomyces cerevisiae J.Biomol.Nmr, 38, 2007
4IJP	Crystal Structure of Human PRPF4B kinase domain in complex with 4-{5-[(2-Chloro-pyridin-4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine 分子名称: 4-(5-{[(2-chloropyridin-4-yl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide, SULFATE ION, Serine/threonine-protein kinase PRP4 homolog 著者 Mechin, I, Haas, K, Chen, X, Zhang, Y, McLean, L. 登録日 2012-12-22 公開日 2013-08-28 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288, 2013
2HW6	Crystal structure of Mnk1 catalytic domain 分子名称: MAP kinase-interacting serine/threonine-protein kinase 1, SULFATE ION 著者 Jauch, R, Wahl, M.C. 登録日 2006-08-01 公開日 2006-08-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment. Embo J., 25, 2006
2L03	Spatial structure of water-soluble Lynx1 分子名称: Ly-6/neurotoxin-like protein 1 著者 Mineev, K.S, Shenkarev, Z.O, Arseniev, A.S. 登録日 2010-06-30 公開日 2011-01-19 最終更新日 2014-10-01 実験手法 SOLUTION NMR 主引用文献 NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1 J.Biol.Chem., 286, 2011
2HTW	N4 neuraminidase in complex with DANA 分子名称: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, Neuraminidase 著者 Russell, R.J, Haire, L.F, Stevens, D.J, Collins, P.J, Lin, Y.P, Blackburn, G.M, Hay, A.J, Gamblin, S.J, Skehel, J.J. 登録日 2006-07-26 公開日 2006-09-05 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature, 443, 2006
2HLV	Bovine Odorant Binding Protein deswapped triple mutant 分子名称: 3,6-BIS(METHYLENE)DECANOIC ACID, GLYCEROL, Odorant-binding protein 著者 Spinelli, S, Tegoni, M, Cambillau, C. 登録日 2006-07-10 公開日 2008-03-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Deswapping bovine odorant binding protein. Biochim.Biophys.Acta, 1784, 2008
6YLL	Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors 分子名称: Mitogen-activated protein kinase 6, ~{N}4-[3-(4-methoxyphenyl)-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]cyclohexane-1,4-diamine 著者 Graedler, U. 登録日 2020-04-07 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors. Bioorg.Med.Chem.Lett., 30, 2020
2HVZ	Solution structure of the RRM domain of SR rich factor 9G8 分子名称: Splicing factor, arginine/serine-rich 7 著者 Tintaru, A.M, Hautbergue, G.M, Golovanov, A.P, Lian, L.Y, Wilson, S.A. 登録日 2006-07-31 公開日 2006-11-21 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. Embo J., 25, 2006
2HV4	NMR solution structure refinement of yeast iso-1-ferrocytochrome c 分子名称: Cytochrome c iso-1, HEME C 著者 Assfalg, M, Bertini, I, Del Conte, R, Turano, P. 登録日 2006-07-27 公開日 2006-09-26 最終更新日 2021-10-20 実験手法 SOLUTION NMR 主引用文献 Cytochrome c and organic molecules: solution structure of the p-aminophenol adduct. Biochemistry, 46, 2007
6YNB	Crystal structure of cAMP-dependent Protein Kinase (PKA) in complex with short-chain Fasudil-derivative N-(2-aminoethyl)isoquinoline-5-sulfonamide (soaked) 分子名称: DIMETHYL SULFOXIDE, N-(2-AMINOETHYL)ISOQUINOLINE-5-SULFONAMIDE, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2020-04-13 公開日 2020-10-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Two Methods, One Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses. Chemmedchem, 16, 2021
2L59	Solution Structures of Oxidized and Reduced Thioredoxin C from M. tb 分子名称: Thioredoxin 著者 Olson, A.L, Cai, S, Sem, D.S. 登録日 2010-10-28 公開日 2011-10-26 最終更新日 2013-04-03 実験手法 SOLUTION NMR 主引用文献 Solution structures of Mycobacterium tuberculosis thioredoxin C and models of intact thioredoxin system suggest new approaches to inhibitor and drug design. Proteins, 81, 2013
2L5P	Solution NMR structure of protein lipocalin 12 from rat epididymis 分子名称: Lipocalin 12 著者 Peng, Y, Lin, D. 登録日 2010-11-03 公開日 2011-04-13 最終更新日 2011-09-14 実験手法 SOLUTION NMR 主引用文献 Solution structure of the protein lipocalin 12 from rat epididymis Proteins, 79, 2011
6YPJ	Crystal Structure of CK2alpha with Compound 1 bound 分子名称: 4-[(4-phenyl-1,3-thiazol-2-yl)amino]benzoic acid, ACETATE ION, Casein kinase II subunit alpha 著者 Brear, P, Hyvonen, M. 登録日 2020-04-16 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Proposed Allosteric Inhibitors Bind to the ATP Site of CK2 alpha. J.Med.Chem., 63, 2020
2L8M	Reduced and CO-bound cytochrome P450cam (CYP101A1) 分子名称: CAMPHOR, CARBON MONOXIDE, CHLORIDE ION, ... 著者 Pochapsky, T.C, Pochapsky, S.S, Dang, M, Asciutto, E, Madura, J. 登録日 2011-01-19 公開日 2011-02-16 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Experimentally Restrained Molecular Dynamics Simulations for Characterizing the Open States of Cytochrome P450(cam). Biochemistry, 50, 2011
2HSP	SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA 分子名称: PHOSPHOLIPASE C-GAMMA (SH3 DOMAIN) 著者 Kohda, D, Hatanaka, H, Odaka, M, Inagaki, F. 登録日 1994-06-13 公開日 1994-08-31 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SH3 domain of phospholipase C-gamma. Cell(Cambridge,Mass.), 72, 1993
2LHM	CRYSTAL STRUCTURES OF THE APO-AND HOLOMUTANT HUMAN LYSOZYMES WITH AN INTRODUCED CA2+ BINDING SITE 分子名称: HUMAN LYSOZYME 著者 Inaka, K, Matsushima, M. 登録日 1991-10-02 公開日 1992-04-15 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of the apo- and holomutant human lysozymes with an introduced Ca2+ binding site. J.Biol.Chem., 266, 1991
6YG0	Crystal structure of S287D,T291D MKK7 (MAP2K7), apo form 分子名称: Dual specificity mitogen-activated protein kinase kinase 7 著者 Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2020-03-27 公開日 2020-08-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities. Cell Chem Biol, 27, 2020
6YG6	Crystal structure of MKK7 (MAP2K7) covalently bound with type-II inhibitor TL10-105 分子名称: 1,2-ETHANEDIOL, Dual specificity mitogen-activated protein kinase kinase 7, ~{N}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{S})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide 著者 Chaikuad, A, Tan, L, Wang, J, Liang, Y, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2020-03-27 公開日 2020-08-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities. Cell Chem Biol, 27, 2020
2HOT	Phage selected homeodomain bound to modified DNA 分子名称: 3-PROP-2-YN-1-YL-1,3-OXAZOLIDIN-2-ONE, 5'-D(*AP*TP*CP*CP*GP*GP*GP*GP*AP*TP*TP*AP*CP*AP*TP*GP*GP*CP*AP*AP*A)-3', 5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*CP*CP*CP*CP*GP*GP*A)-3', ... 著者 Feldman, M.E, Simon, M.D, Shokat, K.M. 登録日 2006-07-16 公開日 2006-12-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Structure and properties of a re-engineered homeodomain protein-DNA interface. Acs Chem.Biol., 1, 2006
6YG5	Crystal structure of MKK7 (MAP2K7) in complex with ASC69 分子名称: Dual specificity mitogen-activated protein kinase kinase 7, [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile 著者 Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2020-03-27 公開日 2020-08-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities. Cell Chem Biol, 27, 2020
2HXL	crystal structure of Chek1 in complex with inhibitor 1 分子名称: 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE, Serine/threonine-protein kinase Chk1 著者 Yan, Y. 登録日 2006-08-03 公開日 2007-06-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
2HXK	Crystal structure of S-nitroso thioredoxin 分子名称: ETHANOL, Thioredoxin 著者 Weichsel, A, Montfort, W.R. 登録日 2006-08-03 公開日 2006-12-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Buried s-nitrosocysteine revealed in crystal structures of human thioredoxin. Biochemistry, 46, 2007
6YNR	Crystal structure of the cAMP-dependent protein kinase A in complex with 1,7-Naphthyridin-8-amine (soaked) and PKI (5-24) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,7-naphthyridin-8-amine, DIMETHYL SULFOXIDE, ... 著者 Oebbeke, M, Heine, A, Klebe, G. 登録日 2020-04-14 公開日 2020-10-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Two Methods, One Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses. Chemmedchem, 16, 2021

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