PDB: 36840 件ウェブページステータス検索Chemie searchBIRD

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8TXH	Crystal structure of KRAS G12D in complex with GDP and compound 14 分子名称: (4P)-2-amino-4-{4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}-6-(trifluoromethyl)quinazolin-7-yl}-7-fluoro-1-benzothiophene-3-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Chen, P, Irimia, A, Yang, Z. 登録日 2023-08-23 公開日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors. Acs Med.Chem.Lett., 14, 2023
8TXE	Crystal structure of KRAS G12D in complex with GDP and compound 5 分子名称: (6M)-6-(6-chloro-4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}quinazolin-7-yl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Chen, P, Irimia, A, Yang, Z. 登録日 2023-08-23 公開日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors. Acs Med.Chem.Lett., 14, 2023
8QAU	Outer kinetochore Ndc80-Dam1 alpha/beta-tubulin complex 分子名称: DASH complex subunit DAM1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Muir, K.W, Barford, D. 登録日 2023-08-23 公開日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.54 Å) 主引用文献 Mechanism of outer kinetochore assembly on microtubules and its regulation by mitotic error correction Biorxiv, 2023
8W41	Cryo-EM structure of Myosin VI in the autoinhibited state 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... 著者 Niu, F, Wei, Z. 登録日 2023-08-23 公開日 2024-02-21 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.54 Å) 主引用文献 Autoinhibition and activation of myosin VI revealed by its cryo-EM structure. Nat Commun, 15, 2024
8QA2	Cryo-EM structure of Cx26 solubilised in LMNG: classification on subunit A; Nconst-mon conformation 分子名称: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE 著者 Brotherton, D.H, Cameron, A.D. 登録日 2023-08-22 公開日 2024-06-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2. Elife, 13, 2024
8Q9Z	Cryo-EM structure of Cx26 gap junction K125E mutant in bicarbonate buffer (classification on hemichannel) 分子名称: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE 著者 Brotherton, D.H, Cameron, A.D. 登録日 2023-08-22 公開日 2024-06-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2. Elife, 13, 2024
8QA1	Cryo-EM structure of Cx26 solubilised in LMNG - Hemichannel classification NFlex conformation 分子名称: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE 著者 Brotherton, D.H, Cameron, A.D. 登録日 2023-08-22 公開日 2024-06-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2. Elife, 13, 2024
8QA3	Cryo-EM structure of Cx26 solubilised in LMNG: classification on subunit A; NFlex conformation 分子名称: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE 著者 Brotherton, D.H, Cameron, A.D. 登録日 2023-08-22 公開日 2024-06-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2. Elife, 13, 2024
8QA0	Cryo-EM structure of Cx26 solubilised in LMNG - hemichannel classification - NConst conformation 分子名称: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE 著者 Brotherton, D.H, Cameron, A.D. 登録日 2023-08-22 公開日 2024-06-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2. Elife, 13, 2024
8KI3	Structure of the human ATP synthase bound to bedaquiline (composite) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase F(0) complex subunit B1, ... 著者 Lai, Y, Zhang, Y, Gong, H. 登録日 2023-08-22 公開日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Structure of Mycobacterium tuberculosis ATP synthase To Be Published
8Q9S	STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE INHIBITOR SGC-CK2-1 分子名称: 1,2-ETHANEDIOL, Casein kinase II subunit alpha', ~{N}-[5-[[3-cyano-7-(cyclopropylamino)-3~{H}-pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methyl-phenyl]propanamide 著者 Werner, C, Lindenblatt, D, Niefind, K. 登録日 2023-08-21 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.352 Å) 主引用文献 Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2alpha Cys336Ser as an Exquisite Crystallographic Tool Kinases Phosphatases, 2023
8KH5	Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Nie, Y, Qiu, Z, Zheng, S, Chen, S. 登録日 2023-08-21 公開日 2023-10-18 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8KH4	Cryo-EM structure of the GPR161-Gs complex 分子名称: CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Nie, Y, Qiu, Z, Zheng, S, Chen, S. 登録日 2023-08-21 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8TWU	Crystal structure of Cytochrome P450 AspB bound to N1-methylated cyclo-L-Trp-L-Pro 分子名称: (3S,5S,8aS)-3-[(1-methyl-1H-indol-3-yl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, Cytochrome P450 AspB, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Gering, H.E, Li, X, Tang, H, Swartz, P.D, Chang, W.-C, Makris, T.M. 登録日 2023-08-21 公開日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization. J.Am.Chem.Soc., 145, 2023
8KGZ	Crystal structure of single-chain Fv antibody against antigen peptide from SARS-CoV2 S-spike protein 分子名称: Thioredoxin 1,scFv 著者 Ma, Q.Q, Zhang, B.L, Cheng, X.Y, Huang, Y.Q, Su, Z.D. 登録日 2023-08-20 公開日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Crystal structure of sheep scFv antibody against an antigen peptide of SARS-CoV2 S-spike protein To Be Published
8TWD	Structure of IraM-bound RssB 分子名称: ACETATE ION, Anti-adapter protein IraM, Regulator of RpoS 著者 Brugger, C, Deaconescu, A.M. 登録日 2023-08-20 公開日 2024-01-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 IraM remodels the RssB segmented helical linker to stabilize sigma s against degradation by ClpXP. J.Biol.Chem., 300, 2023
8KGK	Cryo-EM structure of the GPR61-Gs complex 分子名称: G-protein coupled receptor 61, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Nie, Y, Qiu, Z, Zheng, S. 登録日 2023-08-19 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8Q91	Structure of the human 20S U5 snRNP core 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Schneider, S, Galej, W.P. 登録日 2023-08-19 公開日 2024-03-27 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure of the human 20S U5 snRNP. Nat.Struct.Mol.Biol., 31, 2024
8Q8B	Crystal structure of Apis mellifera glutathione transferase delta 1, mutant C127S 分子名称: Glutathione S-transferase D1 isoform X1, SULFATE ION 著者 Schwartz, M, Neiers, F. 登録日 2023-08-18 公開日 2023-10-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-activity analysis suggests an olfactory function for the unique antennal delta glutathione transferase of Apis mellifera. Febs Lett., 597, 2023
8Q89	Crystal structure of Apis mellifera glutathione transferase delta 1 in a covalent dimeric state 分子名称: Glutathione S-transferase D1 isoform X1 著者 Schwartz, M, Neiers, F. 登録日 2023-08-18 公開日 2023-10-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure-activity analysis suggests an olfactory function for the unique antennal delta glutathione transferase of Apis mellifera. Febs Lett., 597, 2023
8Q8A	Crystal structure of Apis mellifera glutathione transferase delta 1, mutant M126L 分子名称: Glutathione S-transferase D1 isoform X1, SULFATE ION 著者 Schwartz, M, Neiers, F. 登録日 2023-08-18 公開日 2023-10-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure-activity analysis suggests an olfactory function for the unique antennal delta glutathione transferase of Apis mellifera. Febs Lett., 597, 2023
8Q7W	Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3) 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. 登録日 2023-08-17 公開日 2024-04-17 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of human U5 snRNP late biogenesis and recycling. Nat.Struct.Mol.Biol., 31, 2024
8KG2	Crystal structure of p97-N/D1 hexamer in complex with FAF1-UBX domain 分子名称: ADENOSINE-5'-DIPHOSPHATE, FAS-associated factor 1, Transitional endoplasmic reticulum ATPase 著者 Kang, W. 登録日 2023-08-17 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal Structure of p97-N/D1 Hexamer Complexed with FAF1 UBX Domain J. Korean Chem. Soc., 2024
8Q7V	Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1) 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. 登録日 2023-08-17 公開日 2024-04-17 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis of human U5 snRNP late biogenesis and recycling. Nat.Struct.Mol.Biol., 31, 2024
8Q7X	Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4) 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. 登録日 2023-08-17 公開日 2024-04-17 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Structural basis of human U5 snRNP late biogenesis and recycling. Nat.Struct.Mol.Biol., 31, 2024

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