PDB: 71589 件ウェブページステータス検索Chemie searchBIRD

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8Q5L	PqsR coinducer binding domain of Pseudomonas aeruginosa with ligand 2f: 2-(4-(3-((6-chloro-1-isopropyl-1H-benzo[d]imidazol-2-yl)amino)-2-hydroxypropoxy)phenyl)acetonitrile 分子名称: 2-[4-[(2~{S})-3-[(6-chloranyl-1-propan-2-yl-benzimidazol-2-yl)amino]-2-oxidanyl-propoxy]phenyl]ethanenitrile, Transcriptional regulator MvfR 著者 Markham-Lee, Z.J, Emsley, J. 登録日 2023-08-09 公開日 2024-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Design, Synthesis, and Evaluation of New 1 H -Benzo[ d ]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections. J.Med.Chem., 67, 2024
8CRO	Cryo-EM structure of Pyrococcus furiosus transcription elongation complex 分子名称: DNA Non-Template Strand, DNA Template Strand, DNA-directed RNA polymerase subunit Rpo10, ... 著者 Tarau, D.M, Grunberger, F, Reichelt, R, Heiss, F.B, Pilsl, M, Hausner, W, Engel, C, Grohmann, D. 登録日 2023-03-08 公開日 2024-04-17 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment. Nucleic Acids Res., 52, 2024
3NQ8	Optimization of the in silico designed Kemp eliminase KE70 by computational design and directed evolution R4 8/5A 分子名称: BENZAMIDINE, NITRATE ION, deoxyribose phosphate aldolase 著者 Khersonsky, O, Rothlisberge, D, Wollacott, A.M, Dym, O, Baker, D, Tawfik, D.S, Israel Structural Proteomics Center (ISPC) 登録日 2010-06-29 公開日 2011-02-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution J.Mol.Biol., 407, 2011
6ALR	VioC L-arginine hydroxylase bound to the vanadyl ion, L-arginine, and succinate 分子名称: ARGININE, Alpha-ketoglutarate-dependent L-arginine hydroxylase, SUCCINIC ACID, ... 著者 Mitchell, A.J, Dunham, N.P, Bergman, J.A, Boal, A.K. 登録日 2017-08-08 公開日 2017-09-06 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase. J. Am. Chem. Soc., 139, 2017
6AM9	Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9, with Ser-bound in a predominantly closed state. 分子名称: 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, SODIUM ION, Tryptophan synthase beta chain 1, ... 著者 Buller, A.R, van Roye, P. 登録日 2017-08-09 公開日 2018-05-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble. J. Am. Chem. Soc., 140, 2018
6EJH	Crystal structure of the G343C mutant of Candida albicans Mep2 分子名称: Ammonium transporter 著者 van den Berg, B, van den Berg, B. 登録日 2017-09-21 公開日 2018-10-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Crystal structure of the G343C mutant of Candida albicans Mep2 To Be Published
6AM8	Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9 with Trp bound as E(Aex2) 分子名称: SODIUM ION, TRYPTOPHAN, Tryptophan synthase beta chain 1, ... 著者 Buller, A.R, van Roye, P. 登録日 2017-08-09 公開日 2018-05-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble. J. Am. Chem. Soc., 140, 2018
6EJU	Nuclease NucB from Bacillus licheniformis in P1 space group 分子名称: Nuclease, SULFATE ION 著者 Stransky, J, Dohnalek, J, Oestergaard, L.A. 登録日 2017-09-23 公開日 2019-04-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of novel nuclease NucB from Bacillus licheniformis To Be Published
6S8J	Structure of ZEBOV GP in complex with 5T0180 antibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope Glycoprotein 1, Envelope glycoprotein, ... 著者 Diskin, R, Cohen-Dvashi, H. 登録日 2019-07-10 公開日 2020-02-12 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (2.91 Å) 主引用文献 Structural Basis for a Convergent Immune Response against Ebola Virus. Cell Host Microbe, 27, 2020
6I6U	Circular permutant of ribosomal protein S6, adding 9aa to N terminal of P81-82, L75A mutant 分子名称: 30S ribosomal protein S6,30S ribosomal protein S6 著者 Wang, H, Logan, D.T, Oliveberg, M. 登録日 2018-11-15 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Exposing the distinctive modular behavior of beta-strands and alpha-helices in folded proteins. Proc.Natl.Acad.Sci.USA, 117, 2020
6AW2	Crystal structure of the HopQ-CEACAM1 complex 分子名称: Carcinoembryonic antigen-related cell adhesion molecule 1, HopQ 著者 Bonsor, D.A, Sundberg, E.J. 登録日 2017-09-05 公開日 2018-05-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 TheHelicobacter pyloriadhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA. EMBO J., 37, 2018
6S8I	Structure of ZEBOV GP in complex with 3T0265 antibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, Enveloped Glycoprotein 1, ... 著者 Diskin, R, Cohen-Dvashi, H. 登録日 2019-07-10 公開日 2020-02-12 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (2.99 Å) 主引用文献 Structural Basis for a Convergent Immune Response against Ebola Virus. Cell Host Microbe, 27, 2020
6BFI	Vinculin homolog in a sponge (phylum Porifera) reveals vertebrate-like cell adhesions involved in early multicellular evolution 分子名称: VIN1 著者 Weis, W.I, Chodaparambil, J.V. 登録日 2017-10-26 公開日 2018-06-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Analysis of a vinculin homolog in a sponge (phylum Porifera) reveals that vertebrate-like cell adhesions emerged early in animal evolution. J. Biol. Chem., 293, 2018
6AW3	Crystal structure of the HopQ-CEACAM3 L44Q complex 分子名称: Carcinoembryonic antigen-related cell adhesion molecule 3, HopQ 著者 Bonsor, D.A, Sundberg, E.J. 登録日 2017-09-05 公開日 2018-05-16 最終更新日 2018-07-11 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 TheHelicobacter pyloriadhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA. EMBO J., 37, 2018
6ELC	Crystal Structure of O-linked Glycosylated VSG3 分子名称: Variant surface glycoprotein, alpha-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Stebbins, C.E. 登録日 2017-09-28 公開日 2018-07-11 最終更新日 2022-03-30 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat. Nat Microbiol, 3, 2018
6OWL	RNA oligonucleotides with 3'-arabino guanosine co-crystallized with GMP 分子名称: RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*R)-3'), RNA (5'-R(P*G)-3') 著者 Szostak, J.W, Kim, S, Zhang, W. 登録日 2019-05-10 公開日 2020-02-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2'-Deoxynucleotides. J.Am.Chem.Soc., 142, 2020
6B79	Curved pair of sheets formed from SOD1 residues 28-38 with familial mutation G37R. 分子名称: 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid, Superoxide dismutase [Cu-Zn] 著者 Sangwan, S, Sawaya, M.R, Eisenberg, D.S. 登録日 2017-10-03 公開日 2018-05-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations. Protein Sci., 27, 2018
6UZ1	Noncanonical binding of single-chain A6 TCR variant S3-4 in complex with Tax/HLA-A2 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-2-microglobulin, LEU-LEU-PHE-GLY-TYR-PRO-VAL-TYR-VAL, ... 著者 Ma, J, Singh, N.K. 登録日 2019-11-14 公開日 2020-10-28 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes. Biochemistry, 59, 2020
3NPV	Optimization of the in silico designed Kemp eliminase KE70 by computational design and directed evolution 分子名称: deoxyribose phosphate aldolase 著者 Khersonsky, O, Rothlisberge, D, Wollacott, A.M, Dym, O, Baker, D, Tawfik, D.S, Israel Structural Proteomics Center (ISPC) 登録日 2010-06-29 公開日 2011-02-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution J.Mol.Biol., 407, 2011
7AVY	MerTK kinase domain in complex with quinazoline-based inhbitor 分子名称: N-(2-(2-cyclopropylethoxy)pyrimidin-5-yl)-7-methoxy-6-(piperidin-4-ylmethoxy)quinazolin-4-amine, SULFATE ION, Tyrosine-protein kinase Mer 著者 Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S. 登録日 2020-11-06 公開日 2021-03-03 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021
6VCK	Crystal structure of E.coli RppH-DapF in complex with GDP, Mg2+ and F- 分子名称: CHLORIDE ION, Diaminopimelate epimerase, FLUORIDE ION, ... 著者 Gao, A, Vasilyev, N, Kaushik, A, Duan, W, Serganov, A. 登録日 2019-12-21 公開日 2020-02-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH. Nucleic Acids Res., 48, 2020
6VCP	Crystal structure of E.coli RppH in complex with UTP 分子名称: RNA pyrophosphohydrolase, URIDINE 5'-TRIPHOSPHATE 著者 Gao, A, Vasilyev, N, Kaushik, A, Duan, W, Serganov, A. 登録日 2019-12-21 公開日 2020-02-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH. Nucleic Acids Res., 48, 2020
7AVX	MerTK kinase domain in complex with NPS-1034 分子名称: 1-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide, Tyrosine-protein kinase Mer 著者 Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S. 登録日 2020-11-06 公開日 2021-03-03 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021
6J9K	Apo-AcrIIC2 分子名称: AcrIIC2, MAGNESIUM ION 著者 Zhu, Y.L, Gao, A, Serganov, A, Gao, P. 登録日 2019-01-23 公開日 2019-03-06 最終更新日 2022-03-23 実験手法 X-RAY DIFFRACTION (2.234 Å) 主引用文献 Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins. Mol. Cell, 74, 2019
7AW0	MerTK kinase domain in complex with purine inhibitor 分子名称: 2-(cyclopentyloxy)-9-(2,6-difluorobenzyl)-N-methyl-9H-purin-6-amine, Tyrosine-protein kinase Mer 著者 Schimpl, M, Nissink, J.W.M, Blackett, C, Clarke, M, Disch, J, Goldberg, K, Guilinger, J, Hennessy, E.J, Jetson, R, Ginkunja, D, Hardaker, E, Keefe, A, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S, Zhang, Y. 登録日 2020-11-06 公開日 2021-03-03 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.893 Å) 主引用文献 Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021

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