PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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6PZI	Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP only 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8 著者 Shyng, S.L, Yoshioka, C, Martin, G.M, Sung, M.W. 登録日 2019-07-31 公開日 2019-08-14 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM. Elife, 8, 2019
5W59	Crystal structure of a monomeric human FGF9 in complex with the ectodomain of human FGFR1c 分子名称: Fibroblast growth factor 9, Fibroblast growth factor receptor 1, SULFATE ION 著者 Mohammadi, M, Ma, J, Liu, Y. 登録日 2017-06-14 公開日 2017-08-16 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.498 Å) 主引用文献 Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization. Structure, 25, 2017
6PSS	Escherichia coli RNA polymerase promoter unwinding intermediate (TRPi1.5a) with TraR and mutant rpsT P2 promoter 分子名称: DNA (85-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. 登録日 2019-07-13 公開日 2020-03-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Stepwise Promoter Melting by Bacterial RNA Polymerase. Mol.Cell, 78, 2020
6PZA	Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide 分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... 著者 Shyng, S.L, Yoshioka, C, Martin, G.M, Sung, M.W. 登録日 2019-07-31 公開日 2019-08-14 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.74 Å) 主引用文献 Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM. Elife, 8, 2019
6OEM	Cryo-EM structure of mouse RAG1/2 PRC complex (DNA0) 分子名称: DNA (46-MER), DNA (57-MER), High mobility group protein B1, ... 著者 Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. 登録日 2019-03-27 公開日 2020-01-29 最終更新日 2025-05-21 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
5VPB	Transcription factor FosB/JunD bZIP domain in its oxidized form, type-I crystal 分子名称: CHLORIDE ION, Protein fosB, Transcription factor jun-D 著者 Yin, Z, Machius, M, Rudenko, G. 登録日 2017-05-04 公開日 2017-09-06 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.691 Å) 主引用文献 Activator Protein-1: redox switch controlling structure and DNA-binding. Nucleic Acids Res., 45, 2017
8OID	Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the N111S mutation 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. 登録日 2023-03-22 公開日 2023-08-09 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
5VPD	Transcription factor FosB/JunD bZIP domain in its oxidized form, type-III crystal 分子名称: CHLORIDE ION, Protein fosB, SODIUM ION, ... 著者 Yin, Z, Machius, M, Rudenko, G. 登録日 2017-05-04 公開日 2017-09-06 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Activator Protein-1: redox switch controlling structure and DNA-binding. Nucleic Acids Res., 45, 2017
8OI8	Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the R183W mutation 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. 登録日 2023-03-22 公開日 2023-08-16 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.28 Å) 主引用文献 Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
5VSW	X-ray crystal structure of Escherichia coli RNA polymerase and DksA/ppGpp complex 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Murakami, K.S, Molodtsov, V. 登録日 2017-05-12 公開日 2017-06-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (4.295 Å) 主引用文献 Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
5W21	Crystal Structure of a 1:1:1 FGF23-FGFR1c-aKlotho Ternary Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibroblast growth factor 23, Fibroblast growth factor receptor 1, ... 著者 Mohammadi, M. 登録日 2017-06-05 公開日 2018-01-24 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling. Nature, 553, 2018
5W1T	X-ray crystal structure of Escherichia coli RNA polymerase and DksA complex 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Murakami, K.S, Molodtsov, V. 登録日 2017-06-04 公開日 2017-06-14 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
6QCJ	Human Sirt6 in complex with ADP-ribose and the inhibitor catechin gallate 分子名称: (2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, 1,2-ETHANEDIOL, NAD-dependent protein deacetylase sirtuin-6, ... 著者 You, W, Steegborn, C. 登録日 2018-12-28 公開日 2019-12-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives. Sci Rep, 9, 2019
6PSQ	Escherichia coli RNA polymerase closed complex (TRPc) with TraR and rpsT P2 promoter 分子名称: CHAPSO, DNA (85-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. 登録日 2019-07-13 公開日 2020-03-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Stepwise Promoter Melting by Bacterial RNA Polymerase. Mol.Cell, 78, 2020
6OSJ	Cryo-EM structure of the N-terminally acetylated full length alpha-synuclein fibrils (Ac1-140) 分子名称: Alpha-synuclein 著者 Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. 登録日 2019-05-01 公開日 2019-09-25 最終更新日 2025-06-04 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
5WE8	Crystal structure of WNK1 in complex with N-{(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl}-2-(3-methoxyphenyl)-N-methylquinoline-4-carboxamide (compound 8) 分子名称: MANGANESE (II) ION, N-{(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl}-2-(3-methoxyphenyl)-N-methylquinoline-4-carboxamide, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Xie, X, Kohls, D. 登録日 2017-07-07 公開日 2017-08-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.006 Å) 主引用文献 Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J. Med. Chem., 60, 2017
6NPJ	Structure of the NKCC1 CTD 分子名称: Sodium-potassium-chloride cotransporter 1 著者 Feng, L, Liao, M.F, Orlando, B, Zhang, J.R. 登録日 2019-01-17 公開日 2019-07-31 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structure and mechanism of the cation-chloride cotransporter NKCC1. Nature, 572, 2019
6OEN	Cryo-EM structure of mouse RAG1/2 PRC complex (DNA1) 分子名称: CALCIUM ION, DNA (46-MER), DNA (57-MER), ... 著者 Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. 登録日 2019-03-27 公開日 2020-01-29 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
5I20	Crystal structure of protein 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, SULFATE ION, Uncharacterized protein 著者 Ishitani, R, Nureki, O. 登録日 2016-02-08 公開日 2016-06-01 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for amino acid export by DMT superfamily transporter YddG. Nature, 534, 2016
5VJ7	Ferredoxin NADP Oxidoreductase (Xfn) 分子名称: FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, Ferredoxin-NADP(+) reductase subunit alpha, ... 著者 Zadvornyy, O.A, Nguyen, D.M.N, Schut, G.J, Lipscomb, G.L, Tokmina-Lukaszewska, M, Adams, M.W.W, Peters, J.W. 登録日 2017-04-18 公開日 2017-07-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Two functionally distinct NADP(+)-dependent ferredoxin oxidoreductases maintain the primary redox balance of Pyrococcus furiosus. J. Biol. Chem., 292, 2017
5VPC	Transcription factor FosB/JunD bZIP domain in its oxidized form, type-II crystal 分子名称: CHLORIDE ION, Protein fosB, SODIUM ION, ... 著者 Yin, Z, Machius, M.C, Rudenko, G. 登録日 2017-05-04 公開日 2017-09-06 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.498 Å) 主引用文献 Activator Protein-1: redox switch controlling structure and DNA-binding. Nucleic Acids Res., 45, 2017
6PZ9	Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11, ... 著者 Shyng, S.L, Yoshioka, C, Martin, G.M, Sung, M.W. 登録日 2019-07-31 公開日 2019-08-14 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.65 Å) 主引用文献 Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM. Elife, 8, 2019
5ITD	Crystal structure of PI3K alpha with PI3K delta inhibitor 分子名称: 5-{4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl}-2-methoxypyridine-3-carbonitrile, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Knapp, M.S, Elling, R.A. 登録日 2016-03-16 公開日 2016-09-07 最終更新日 2025-04-09 実験手法 X-RAY DIFFRACTION (3.02 Å) 主引用文献 Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors. Acs Med.Chem.Lett., 7, 2016
5IPL	SigmaS-transcription initiation complex with 4-nt nascent RNA 分子名称: DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Liu, B, Zuo, Y, Steitz, T.A. 登録日 2016-03-09 公開日 2016-03-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
6OET	Cryo-EM structure of mouse RAG1/2 STC complex 分子名称: CALCIUM ION, DNA (30-MER), DNA (39-MER), ... 著者 Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. 登録日 2019-03-27 公開日 2020-01-22 最終更新日 2025-05-21 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 How mouse RAG recombinase avoids DNA transposition. Nat.Struct.Mol.Biol., 27, 2020

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