5WE8
Crystal structure of WNK1 in complex with N-{(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl}-2-(3-methoxyphenyl)-N-methylquinoline-4-carboxamide (compound 8)
Summary for 5WE8
Entry DOI | 10.2210/pdb5we8/pdb |
Descriptor | Serine/threonine-protein kinase WNK1, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9H4A3 |
Total number of polymer chains | 2 |
Total formula weight | 65882.10 |
Authors | |
Primary citation | Yamada, K.,Levell, J.,Yoon, T.,Kohls, D.,Yowe, D.,Rigel, D.F.,Imase, H.,Yuan, J.,Yasoshima, K.,DiPetrillo, K.,Monovich, L.,Xu, L.,Zhu, M.,Kato, M.,Jain, M.,Idamakanti, N.,Taslimi, P.,Kawanami, T.,Argikar, U.A.,Kunjathoor, V.,Xie, X.,Yagi, Y.I.,Iwaki, Y.,Robinson, Z.,Park, H.M. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J. Med. Chem., 60:7099-7107, 2017 Cited by PubMed: 28771350DOI: 10.1021/acs.jmedchem.7b00708 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.006 Å) |
Structure validation
Download full validation report