PDB: 4050 件ウェブページステータス検索Chemie searchBIRD

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3PWC	Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor 分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2010-12-08 公開日 2011-12-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3PWB	Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor 分子名称: BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2010-12-08 公開日 2011-12-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3PYH	Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor 分子名称: 3-(3-carbamimidoylphenyl)-N-(2'-sulfamoylbiphenyl-4-yl)-1,2-oxazole-4-carboxamide, CALCIUM ION, CHLORIDE ION, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2010-12-13 公開日 2011-12-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3PMJ	Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor 分子名称: CALCIUM ION, CHLORIDE ION, Cationic trypsin, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2010-11-17 公開日 2011-11-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3PM3	Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor 分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2010-11-16 公開日 2011-12-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3Q00	Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor 分子名称: 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, CALCIUM ION, Cationic trypsin, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2010-12-15 公開日 2011-12-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3PLB	Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor 分子名称: BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2010-11-15 公開日 2011-12-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3PLP	Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor 分子名称: 2,7-BIS-(4-AMIDINOBENZYLIDENE)-CYCLOHEPTAN-1-ONE, CALCIUM ION, Cationic trypsin, ... 著者 Tziridis, A, Neumann, P, Braeuer, U, Kolenko, P, Stubbs, M.T. 登録日 2010-11-15 公開日 2011-12-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3PLK	Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor 分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ... 著者 Tziridis, A, Neumann, P, Braeuer, U, Kolenko, P, Stubbs, M.T. 登録日 2010-11-15 公開日 2011-12-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
4Q2K	Bovine alpha chymotrypsin bound to a cyclic peptide inhibitor, 5b 分子名称: (11S)-4,9-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-17,22-dioxa-10,30-diazatetracyclo[21.2.2.2~13,16~.1~5,8~]triaconta-1(25),5,7,13,15,23,26,28-octaene-11-carboxamide, Chymotrypsinogen A 著者 Chan, H.Y, Bruning, J.B, Abell, A.D. 登録日 2014-04-09 公開日 2014-07-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Macrocyclic protease inhibitors with reduced peptide character. Angew.Chem.Int.Ed.Engl., 53, 2014
4INU	Yeast 20S proteasome in complex with the vinyl sulfone LU112 分子名称: N3Phe-Phe(4-NH2CH2)-Leu-Phe(4-NH2CH2)-methyl vinyl sulfone, bound form, Proteasome component C1, ... 著者 Geurink, P.P, van der Linden, W.A, Mirabella, A.C, Gallastegui, N, de Bruin, G, Blom, A.E.M, Voges, M.J, Mock, E.D, Florea, B.I, van der Marel, G.A, Driessen, C, van der Stelt, M, Groll, M, Overkleeft, H.S, Kisselev, A.F. 登録日 2013-01-06 公開日 2013-01-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites. J.Med.Chem., 56, 2013
3S7K	Structure of thrombin mutant Y225P in the E form 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, POTASSIUM ION, Prothrombin 著者 Niu, W, Chen, Z, Gandhi, P, Vogt, A, Pozzi, N, Pele, L.A, Zapata, F, Di Cera, E. 登録日 2011-05-26 公開日 2011-07-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic and Kinetic Evidence of Allostery in a Trypsin-like Protease. Biochemistry, 50, 2011
4INR	Yeast 20S proteasome in complex with the vinyl sulfone LU102 分子名称: N3Phe-Leu-Leu-Phe(4-NH2CH2)-methyl vinyl sulfone, bound form, Proteasome component C1, ... 著者 Geurink, P.P, van der Linden, W.A, Mirabella, A.C, Gallastegui, N, de Bruin, G, Blom, A.E.M, Voges, M.J, Mock, E.D, Florea, B.I, van der Marel, G.A, Driessen, C, van der Stelt, M, Groll, M, Overkleeft, H.S, Kisselev, A.F. 登録日 2013-01-06 公開日 2013-01-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites. J.Med.Chem., 56, 2013
4INT	Yeast 20S proteasome in complex with the vinyl sulfone LU122 分子名称: HMB-Val-Ser-Phe(4-NH2CH2)-methyl vinyl sulfone, bound form, Proteasome component C1, ... 著者 Geurink, P.P, van der Linden, W.A, Mirabella, A.C, Gallastegui, N, de Bruin, G, Blom, A.E.M, Voges, M.J, Mock, E.D, Florea, B.I, van der Marel, G.A, Driessen, C, van der Stelt, M, Groll, M, Overkleeft, H.S, Kisselev, A.F. 登録日 2013-01-06 公開日 2013-01-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites. J.Med.Chem., 56, 2013
3S7H	Structure of thrombin mutant Y225P in the E* form 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Prothrombin 著者 Niu, W, Chen, Z, Gandhi, P, Vogt, A, Pozzi, N, Pele, L.A, Zapata, F, Di Cera, E. 登録日 2011-05-26 公開日 2011-07-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic and Kinetic Evidence of Allostery in a Trypsin-like Protease. Biochemistry, 50, 2011
1BI6	NMR STRUCTURE OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM 分子名称: BROMELAIN INHIBITOR VI 著者 Hatano, K.-I. 登録日 1995-12-07 公開日 1996-04-03 最終更新日 2017-11-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of bromelain inhibitor IV from pineapple stem: structural similarity with Bowman-Birk trypsin/chymotrypsin inhibitor from soybean. Biochemistry, 35, 1996
2F91	1.2A resolution structure of a crayfish trypsin complexed with a peptide inhibitor, SGTI 分子名称: CADMIUM ION, CHLORIDE ION, Serine protease inhibitor I/II, ... 著者 Fodor, K, Harmat, V, Hetenyi, C, Kardos, J, Antal, J, Perczel, A, Patthy, A, Katona, G, Graf, L. 登録日 2005-12-05 公開日 2006-04-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Enzyme:Substrate Hydrogen Bond Shortening during the Acylation Phase of Serine Protease Catalysis. Biochemistry, 45, 2006
3I2A	Crystal structure of a chimeric trypsin inhibitor protein STI(L)-WCI(S) 分子名称: CHLORIDE ION, Chymotrypsin inhibitor 3 著者 Sen, U, Khamrui, S. 登録日 2009-06-29 公開日 2010-02-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Identification of a novel set of scaffolding residues that are instrumental for the inhibitory property of Kunitz (STI) inhibitors. Protein Sci., 19, 2010
2F3C	Crystal structure of infestin 1, a Kazal-type serineprotease inhibitor, in complex with trypsin 分子名称: CALCIUM ION, Cationic trypsin, SULFATE ION, ... 著者 Campos, I.T.N, Tanaka, A.S, Barbosa, J.A.R.G. 登録日 2005-11-20 公開日 2006-12-05 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure. Acta Crystallogr.,Sect.D, 68, 2012
3PO1	Thrombin in complex with Benzothiazole Guanidine 分子名称: ACETATE ION, SODIUM ION, Thrombin heavy chain, ... 著者 Xue, Y. 登録日 2010-11-21 公開日 2011-11-23 最終更新日 2012-07-25 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV. Bioorg.Med.Chem.Lett., 22, 2012
1EUF	BOVINE DUODENASE(NEW SERINE PROTEASE), CRYSTAL STRUCTURE 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DUODENASE, PHOSPHATE ION 著者 Pletnev, V.Z, Zamolodchikova, T.S, Pangborn, W.A, Duax, W.L. 登録日 2000-04-14 公開日 2001-04-14 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of bovine duodenase, a serine protease, with dual trypsin and chymotrypsin-like specificities. Proteins, 41, 2000
1A1Q	HEPATITIS C VIRUS NS3 PROTEINASE 分子名称: NS3 PROTEINASE, ZINC ION 著者 Love, R.A, Parge, H.E, Wickersham, J.A, Hostomsky, Z, Habuka, N, Moomaw, E.W, Adachi, T, Hostomska, Z. 登録日 1997-12-12 公開日 1998-03-25 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell(Cambridge,Mass.), 87, 1996
3P8G	Crystal Structure of MT-SP1 in complex with benzamidine 分子名称: 1,2-ETHANEDIOL, BENZAMIDINE, GLUTATHIONE, ... 著者 Yuan, C, Huang, M, Chen, L. 登録日 2010-10-13 公開日 2011-08-03 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1. Bmc Struct.Biol., 11, 2011
1L2E	Human Kallikrein 6 (hK6) Active Form with benzamidine inhibitor 分子名称: BENZAMIDINE, Kallikrein 6, MAGNESIUM ION 著者 Bernett, M.J, Blaber, S.I, Scarisbrick, I.A, Blaber, M. 登録日 2002-02-20 公開日 2002-05-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system. J.Biol.Chem., 277, 2002
1LQE	CRYSTAL STRUCTURE OF TRYPSIN IN COMPLEX WITH 79. 分子名称: CALCIUM ION, SULFATE ION, TRYPSIN, ... 著者 Schreuder, H.A, Liesum, A. 登録日 2002-05-10 公開日 2003-05-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa. J.Med.Chem., 45, 2002

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