1.2A resolution structure of a crayfish trypsin complexed with a peptide inhibitor, SGTI

Replaces:  1YR4

Summary for 2F91

Descriptorhepatopancreas trypsin, Serine protease inhibitor I/II, CADMIUM ION, ... (5 entities in total)
Functional Keywordsserine protease, trypsin, canonical inhibitor, atomic resolution, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourcePontastacus leptodactylus (narrow-clawed crayfish)
Cellular locationSecreted O46162
Total number of polymer chains2
Total molecular weight29646.12
Fodor, K.,Harmat, V.,Hetenyi, C.,Kardos, J.,Antal, J.,Perczel, A.,Patthy, A.,Katona, G.,Graf, L. (deposition date: 2005-12-05, release date: 2006-04-18, Last modification date: 2011-07-13)
Primary citation
Fodor, K.,Harmat, V.,Neutze, R.,Szilagyi, L.,Graf, L.,Katona, G.
Enzyme:Substrate Hydrogen Bond Shortening during the Acylation Phase of Serine Protease Catalysis.
Biochemistry, 45:2114-2121, 2006
PubMed: 16475800 (PDB entries with the same primary citation)
DOI: 10.1021/bi0517133
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19340.4%2.3%11.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2f91
no rotation
Molmil generated image of 2f91
rotated about x axis by 90°
Molmil generated image of 2f91
rotated about y axis by 90°