PDB: 95574 件ウェブページステータス検索Chemie searchBIRD

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8PDE	Crystal Structure of the MADS-box/MEF2 Domain of MEF2D bound to dsDNA and HDAC4 deacetylase binding motif 分子名称: DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(P*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), HDAC4 (histone deacetylase 4) binding motif peptide:GSGEVKMKLQEFVLNKK, ... 著者 Chinellato, M, Carli, A, Perin, S, Mazzocato, Y, Biondi, B, Di Giorgio, E, Brancolini, C, Angelini, A, Cendron, L. 登録日 2023-06-12 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA. J.Mol.Biol., 436, 2024
4F09	Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2 分子名称: 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine, Tyrosine-protein kinase JAK2 著者 Murray, J.M. 登録日 2012-05-03 公開日 2012-07-04 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2. J.Med.Chem., 55, 2012
8OH4	Subtomogram averaging structure of cofilactin filament inside microtubule lumen of Drosophila S2 cell protrusion. 分子名称: Actin-5C, Cofilin/actin-depolymerizing factor homolog 著者 Ventura Santos, C, Carter, A.P. 登録日 2023-03-20 公開日 2023-05-10 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (16.5 Å) 主引用文献 CryoET shows cofilactin filaments inside the microtubule lumen. Biorxiv, 2023
8PWT	Solution structure of the peptide U11-MYRTX-Tb1a from the venom of the ant Tetramorium bicarinatum 分子名称: U11-myrmicitoxin-Tb1a 著者 Jouvensal, L, Paquet, F, Loth, K. 登録日 2023-07-21 公開日 2023-10-25 最終更新日 2023-11-08 実験手法 SOLUTION NMR 主引用文献 Discovery of an Insect Neuroactive Helix Ring Peptide from Ant Venom. Toxins, 15, 2023
3PR0	Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase 分子名称: 7-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]heptane-1,1-diol, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Mileni, M, Han, G.W, Boger, D.L, Stevens, R.C. 登録日 2010-11-29 公開日 2011-11-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase. J.Am.Chem.Soc., 133, 2011
4BI9	Crystal structure of wild-type SCP2 thiolase from Trypanosoma brucei. 分子名称: 3-KETOACYL-COA THIOLASE, PUTATIVE 著者 Harijan, R.K, Kiema, T.-R, Weiss, M.S, Michels, P.A.M, Wierenga, R.K. 登録日 2013-04-10 公開日 2013-08-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop. Biochem.J., 455, 2013
4BXI	Crystal structure of ATP binding domain of AgrC from Staphylococcus aureus 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACCESSORY GENE REGULATOR PROTEIN C, ACETATE ION, ... 著者 Srivastava, S.K, Rajasree, K, Gopal, B. 登録日 2013-07-12 公開日 2014-06-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Influence of the Agrc-Agra Complex in the Response Time of Staphylococcus Aureus Quorum Sensing J.Bacteriol., 196, 2014
4FBZ	Crystal structure of deltarhodopsin from Haloterrigena thermotolerans 分子名称: (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene, 2,3-DI-PHYTANYL-GLYCEROL, BACTERIORUBERIN, ... 著者 Kouyama, T. 登録日 2012-05-23 公開日 2013-05-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of deltarhodopsin-3 from Haloterrigena thermotolerans Proteins, 81, 2013
1JKJ	E. coli SCS 分子名称: COENZYME A, GLYCEROL, PHOSPHATE ION, ... 著者 Fraser, M.E. 登録日 2001-07-12 公開日 2002-01-30 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Two glutamate residues, Glu 208 alpha and Glu 197 beta, are crucial for phosphorylation and dephosphorylation of the active-site histidine residue in succinyl-CoA synthetase. Biochemistry, 41, 2002
7ZV3	Crystal structure of indoleamine 2,3-dioxygenase 1 (IDO1) in complex with ferric heme and MMG-0472 分子名称: 4-(3-chloro-2-phenethylphenyl)-1H-1,2,3-triazole, GLYCEROL, Indoleamine 2,3-dioxygenase 1, ... 著者 Roehrig, U.F, Reynaud, A, Pojer, F, Michielin, O, Zoete, V. 登録日 2022-05-13 公開日 2022-07-06 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.551 Å) 主引用文献 Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. J Enzyme Inhib Med Chem, 37, 2022
7FBW	Acetylxylan esterase from Caldanaerobacter subterraneus subsp. tengcongensis 分子名称: NICKEL (II) ION, Predicted xylanase/chitin deacetylase 著者 Sasamoto, K, Himiyama, T, Moriyoshi, K, Ohmoto, T, Uegaki, K, Nishiya, Y, Nakamura, T. 登録日 2021-07-13 公開日 2021-10-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of acetylxylan esterase from Caldanaerobacter subterraneus subsp. tengcongensis. Acta Crystallogr.,Sect.F, 77, 2021
4BTH	The LeuA146Trp,PheB24Tyr Double Mutant of the Quorum Quenching N-acyl Homoserine Lactone Acylase PvdQ Has an Altered Substrate Specificity Towards Small Acyl Chains 分子名称: ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT ALPHA, ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT BETA, GLYCEROL 著者 Koch, G, Nadal-Jimenez, P, Reis, C.R, Muntendam, R, Bokhove, M, Melillo, E, Dijkstra, B.W, Cool, R.H, Quax, W.J. 登録日 2013-06-18 公開日 2014-01-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reducing Virulence of the Human Pathogen Burkholderia by Altering the Substrate Specificity of the Quorum-Quenching Acylase Pvdq Proc.Natl.Acad.Sci.USA, 111, 2014
4B31	Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum 分子名称: CALCIUM ION, CATALASE-PHENOL OXIDASE, CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE 著者 Yuzugullu, Y, Trinh, C.H, Pearson, A.R, Ogel, Z.B, McPherson, M.J. 登録日 2012-07-20 公開日 2013-04-10 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Investigating the Active Centre of the Scytalidium Thermophilum Catalase Acta Crystallogr.,Sect.F, 69, 2013
4EXM	The crystal structure of an engineered phage lysin containing the binding domain of pesticin and the killing domain of T4-lysozyme 分子名称: Pesticin, Lysozyme Chimera 著者 Seddiki, N, Noinaj, N, Fairman, J.W, Lukacik, P, Barnard, T.J, Buchanan, S.K. 登録日 2012-04-30 公開日 2012-06-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural engineering of a phage lysin that targets Gram-negative pathogens. Proc.Natl.Acad.Sci.USA, 109, 2012
1IRB	CARBOXYLIC ESTER HYDROLASE 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Sundaralingam, M. 登録日 1997-08-13 公開日 1997-12-24 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface. Biochemistry, 35, 1996
4GCE	Room temperature X-ray diffraction study of a 6-fold molar excess of a cisplatin/carboplatin mixture binding to HEWL, Dataset 3 分子名称: Cisplatin, DIMETHYL SULFOXIDE, Lysozyme C 著者 Helliwell, J.R, Tanley, S.W.M. 登録日 2012-07-30 公開日 2013-01-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The crystal structure analysis of the relative binding of cisplatin and carboplatin in a mixture with histidine in a protein studied at 100 and 300 K with repeated X-ray irradiation. Acta Crystallogr.,Sect.D, 69, 2013
8JIU	Cryo-EM structure of the GLP-1R/GCGR dual agonist SAR425899-bound human GCGR-Gs complex 分子名称: Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Yang, L, Zhou, Q.T, Dai, A.T, Zhao, F.H, Chang, R.L, Ying, T.L, Wu, B.L, Yang, D.H, Wang, M.W, Cong, Z.T. 登録日 2023-05-27 公開日 2023-09-13 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 Structural analysis of the dual agonism at GLP-1R and GCGR. Proc.Natl.Acad.Sci.USA, 120, 2023
3EHB	A D-Pathway Mutation Decouples the Paracoccus Denitrificans Cytochrome c Oxidase by Altering the side chain orientation of a distant, conserved Glutamate 分子名称: CALCIUM ION, COPPER (II) ION, Cytochrome c oxidase subunit 1-beta, ... 著者 Koepke, J, Mueller, H, Peng, G. 登録日 2008-09-12 公開日 2008-09-30 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 A d-pathway mutation decouples the paracoccusdenitrificans cytochrome C oxidase by altering the side-chain orientation of a distant conserved glutamate J.Mol.Biol., 384, 2008
7BYS	Crystal structure of exo-beta-1,3-galactanase from Phanerochaete chrysosporium Pc1,3Gal43A apo form 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CITRIC ACID, ... 著者 Matsuyama, K, Ishida, T, Kishine, N, Fujimoto, Z, Igarashi, K, Kaneko, S. 登録日 2020-04-24 公開日 2020-11-04 最終更新日 2021-01-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Unique active-site and subsite features in the arabinogalactan-degrading GH43 exo-beta-1,3-galactanase from Phanerochaete chrysosporium . J.Biol.Chem., 295, 2020
7BYV	Crystal structure of exo-beta-1,3-galactanase from Phanerochaete chrysosporium Pc1,3Gal43A E208Q with beta-1,3-galactotriose 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Galactan 1,3-beta-galactosidase, ... 著者 Matsuyama, K, Ishida, T, Kishine, N, Fujimoto, Z, Igarashi, K, Kaneko, S. 登録日 2020-04-24 公開日 2020-11-04 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Unique active-site and subsite features in the arabinogalactan-degrading GH43 exo-beta-1,3-galactanase from Phanerochaete chrysosporium . J.Biol.Chem., 295, 2020
6DR7	YopH PTP1B WPD loop Chimera 2 PTPase bound to vanadate 分子名称: ACETATE ION, Targeted effector protein, VANADATE ION 著者 Moise, G, Morales, Y, Johnson, S.J, Hengge, A.C. 登録日 2018-06-11 公開日 2018-08-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.849 Å) 主引用文献 A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases. Biochemistry, 57, 2018
6DKW	Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 3. 分子名称: 5-(1-methyl-1H-imidazol-4-yl)-2-[(1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl)oxy]benzamide, Tyrosine-protein kinase receptor 著者 Greasley, S.E, Brown, D. 登録日 2018-05-31 公開日 2018-07-11 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J. Med. Chem., 61, 2018
8LDH	REFINED CRYSTAL STRUCTURE OF DOGFISH M4 APO-LACTATE DEHYDROGENASE 分子名称: CITRIC ACID, M4 APO-LACTATE DEHYDROGENASE 著者 Abad-Zapatero, C, Rossmann, M.G. 登録日 1988-01-04 公開日 1989-07-12 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Refined crystal structure of dogfish M4 apo-lactate dehydrogenase. J.Mol.Biol., 198, 1987
6E18	Crystal structure of Chlamydomonas reinhardtii HAP2 ectodomain provides structural insights of functional loops in green algae. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... 著者 Baquero, E, Legrand, P, Rey, F.A. 登録日 2018-07-09 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Species-Specific Functional Regions of the Green Alga Gamete Fusion Protein HAP2 Revealed by Structural Studies. Structure, 27, 2019
8JWY	Crystal structure of A2AR-T4L in complex with 2-118 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[2-oxidanylidene-1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]pyridin-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, Adenosine receptor A2a,Endolysin, ... 著者 Weng, Y, Chen, Y, Xu, Y, Song, G. 登録日 2023-06-29 公開日 2023-08-16 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A 2 receptors. Sci China Life Sci, 67, 2024

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