4BTH
The LeuA146Trp,PheB24Tyr Double Mutant of the Quorum Quenching N-acyl Homoserine Lactone Acylase PvdQ Has an Altered Substrate Specificity Towards Small Acyl Chains
Summary for 4BTH
Entry DOI | 10.2210/pdb4bth/pdb |
Related | 2WYB 2WYC 2WYD 2WYE |
Descriptor | ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT ALPHA, ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT BETA, GLYCEROL, ... (4 entities in total) |
Functional Keywords | zymogen, hydrolase, quorum quenching |
Biological source | PSEUDOMONAS AERUGINOSA More |
Cellular location | Periplasm (Probable): Q9I194 Q9I194 |
Total number of polymer chains | 2 |
Total formula weight | 79632.36 |
Authors | Koch, G.,Nadal-Jimenez, P.,Reis, C.R.,Muntendam, R.,Bokhove, M.,Melillo, E.,Dijkstra, B.W.,Cool, R.H.,Quax, W.J. (deposition date: 2013-06-18, release date: 2014-01-22, Last modification date: 2023-12-20) |
Primary citation | Koch, G.,Nadal-Jimenez, P.,Reis, C.R.,Muntendam, R.,Bokhove, M.,Melillo, E.,Dijkstra, B.W.,Cool, R.H.,Quax, W.J. Reducing Virulence of the Human Pathogen Burkholderia by Altering the Substrate Specificity of the Quorum-Quenching Acylase Pvdq Proc.Natl.Acad.Sci.USA, 111:1568-, 2014 Cited by PubMed: 24474783DOI: 10.1073/PNAS.1311263111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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