8VF6
 
 | | Crystal structure of Serine/threonine-protein kinase 33 (STK33) Kinase Domain in complex with inhibitor CDD-2211 | | 分子名称: | Serine/threonine-protein kinase 33, {3-[([1,1'-biphenyl]-2-yl)ethynyl]-1H-indazol-5-yl}[(3R)-3-(dimethylamino)pyrrolidin-1-yl]methanone | | 著者 | Ta, H.M, Kim, C, Ku, K.A, Matzuk, M.M. | | 登録日 | 2023-12-21 | | 公開日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Reversible male contraception by targeted inhibition of serine/threonine kinase 33.
Science, 384, 2024
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4XHH
 | | Structure of C. glabrata Hrr25, Apo state | | 分子名称: | PHOSPHATE ION, Similar to uniprot|P29295 Saccharomyces cerevisiae YPL204w HRR25 | | 著者 | Ye, Q, Corbett, K.D. | | 登録日 | 2015-01-05 | | 公開日 | 2016-01-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.908 Å) | | 主引用文献 | Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator.
Embo J., 35, 2016
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3JUH
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4XJB
 | | X-ray structure of Lysozyme1 | | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION | | 著者 | Huang, C.Y, Olieric, V, Diederichs, K, Wang, M, Caffrey, M. | | 登録日 | 2015-01-08 | | 公開日 | 2015-06-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | In meso in situ serial X-ray crystallography of soluble and membrane proteins.
Acta Crystallogr.,Sect.D, 71, 2015
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4XJG
 | | X-ray structure of Lysozyme B2 | | 分子名称: | BROMIDE ION, Lysozyme C, SODIUM ION | | 著者 | Huang, C.Y, Olieric, V, Diederichs, K, Wang, M, Caffrey, M. | | 登録日 | 2015-01-08 | | 公開日 | 2015-06-03 | | 最終更新日 | 2015-06-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | In meso in situ serial X-ray crystallography of soluble and membrane proteins.
Acta Crystallogr.,Sect.D, 71, 2015
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6R6X
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4XJI
 | | X-ray structure of LysozymeS2 | | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION | | 著者 | Huang, C.Y, Olieric, V, Diederichs, K, Wang, M, Caffrey, M. | | 登録日 | 2015-01-08 | | 公開日 | 2015-06-03 | | 最終更新日 | 2015-06-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | In meso in situ serial X-ray crystallography of soluble and membrane proteins.
Acta Crystallogr.,Sect.D, 71, 2015
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3K4V
 | | New crystal form of HIV-1 Protease/Saquinavir structure reveals carbamylation of N-terminal proline | | 分子名称: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Olajuyigbe, F.M, Demitri, N, Ajele, J.O, Maurizio, E, Randaccio, L, Geremia, S. | | 登録日 | 2009-10-06 | | 公開日 | 2010-06-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Carbamylation of N-terminal proline.
ACS Med Chem Lett, 1, 2010
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6RAV
 | | Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid | | 分子名称: | 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, Complement factor B, SULFATE ION, ... | | 著者 | Adams, C.M, Sellner, H, Ehara, T, Mac Sweeney, A, Crowley, M, Anderson, K, Karki, R, Mainolfi, N, Valeur, E, Sirockin, F, Gerhartz, B, Erbel, P, Hughes, N, Smith, T.M, Cumin, F, Argikar, U, Mogi, M, Sedrani, R, Wiesmann, C, Jaffee, B, Maibaum, J, Flohr, S, Harrison, R, Eder, J. | | 登録日 | 2019-04-08 | | 公開日 | 2019-04-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Proc.Natl.Acad.Sci.USA, 116, 2019
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4XOJ
 | | Structure of bovine trypsin in complex with analogues of sunflower inhibitor 1 (SFTI-1) | | 分子名称: | 1,2-ETHANEDIOL, AMMONIUM ION, CALCIUM ION, ... | | 著者 | Golik, P, Malicki, S, Grudnik, P, Karna, N, Debowski, D, Legowska, A, Wladyka, B, Gitlin, A, Brzozowski, K, Dubin, G, Rolka, K. | | 登録日 | 2015-01-16 | | 公開日 | 2015-08-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (0.91 Å) | | 主引用文献 | Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1).
Chembiochem, 16, 2015
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3KA0
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6RCH
 | | Crystal structure of Casein kinase I isoform delta (CK1 delta) complexed with SR4133 inhibitor | | 分子名称: | 1,2-ETHANEDIOL, Casein kinase I isoform delta, SODIUM ION, ... | | 著者 | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Roush, W.R, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2019-04-11 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Crystal structure of Casein kinase I isoform delta (CK1 delta) complexed with SR4133 inhibitor
To Be Published
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4XC4
 | | Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide | | 分子名称: | CHLORIDE ION, Insulin, SODIUM ION, ... | | 著者 | Bracey, A.W, Magis, A.T, Buschard, K, Osterbye, T, Bailey, K.M, Ostrov, D.A. | | 登録日 | 2014-12-17 | | 公開日 | 2015-02-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | | 主引用文献 | Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide
To Be Published
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3JSD
 | | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus | | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | 著者 | Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. | | 登録日 | 2009-09-10 | | 公開日 | 2010-09-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
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4XID
 | | AntpHD with 15bp DNA duplex | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*AP*GP*AP*AP*AP*GP*CP*CP*AP*TP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*CP*TP*AP*AP*TP*GP*GP*CP*TP*TP*TP*C)-3'), ... | | 著者 | White, M.A, Zandarashvili, L, Iwahara, J. | | 登録日 | 2015-01-06 | | 公開日 | 2015-11-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | | 主引用文献 | Entropic Enhancement of Protein-DNA Affinity by Oxygen-to-Sulfur Substitution in DNA Phosphate.
Biophys.J., 109, 2015
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6R49
 | | Aurora-A in complex with shape-diverse fragment 39 | | 分子名称: | (1~{S},10~{S})-12-cyclopropyl-1-oxidanyl-10-propan-2-yl-9,12-diazatricyclo[8.2.1.0^{2,7}]trideca-2(7),3,5-trien-11-one, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ... | | 著者 | Bayliss, R, McIntyre, P.J. | | 登録日 | 2019-03-22 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.209 Å) | | 主引用文献 | Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Chemistry, 25, 2019
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3K3J
 | | P38alpha bound to novel DFG-out compound PF-00416121 | | 分子名称: | 2-(4-fluorophenyl)-3-oxo-6-pyridin-4-yl-N-[2-(trifluoromethyl)benzyl]-2,3-dihydropyridazine-4-carboxamide, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, Mitogen-activated protein kinase 14 | | 著者 | Kazmirski, S.L, DiNitto, J.P. | | 登録日 | 2009-10-02 | | 公開日 | 2009-11-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | | 主引用文献 | The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38alpha for High Throughput Screening Binding Assay.
Chem.Biol.Drug Des., 74, 2009
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4XJD
 | | X-ray structure of Lysozyme2 | | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION | | 著者 | Huang, C.Y, Olieric, V, Diederichs, K, Wang, M, Caffrey, M. | | 登録日 | 2015-01-08 | | 公開日 | 2015-06-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | | 主引用文献 | In meso in situ serial X-ray crystallography of soluble and membrane proteins.
Acta Crystallogr.,Sect.D, 71, 2015
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4XJH
 | | X-ray structure of LysozymeS1 | | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION | | 著者 | Huang, C.Y, Olieric, V, Diederichs, K, Wang, M, Caffrey, M. | | 登録日 | 2015-01-08 | | 公開日 | 2015-06-03 | | 最終更新日 | 2015-06-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | In meso in situ serial X-ray crystallography of soluble and membrane proteins.
Acta Crystallogr.,Sect.D, 71, 2015
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8YGY
 | | Structure of the KLK1 from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, Kallikrein-1, SULFATE ION, ... | | 著者 | Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y. | | 登録日 | 2024-02-27 | | 公開日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | | 主引用文献 | Structure of the KLK1 from Biortus.
To Be Published
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6RA7
 | | Human tnik in complex with compound 9 | | 分子名称: | 1,2-ETHANEDIOL, 2-[8-azanyl-2-(2-fluoranylpyridin-4-yl)-1,7-naphthyridin-5-yl]propan-2-ol, MAGNESIUM ION, ... | | 著者 | Read, J.A. | | 登録日 | 2019-04-05 | | 公開日 | 2019-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase
To Be Published
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6RAT
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9B7E
 | | S_SAD structure of HEWL using lossy compression data with a compression ratio of 422 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C, ... | | 著者 | Jakoncic, J, Bernstein, H.J, Soares, A.S, Horvat, K. | | 登録日 | 2024-03-27 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Investigation of fast and efficient lossless compression algorithms for macromolecular crystallography experiments
To Be Published
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4XP3
 | | Crystal structure of ERK2 in complex with an inhibitor | | 分子名称: | 2-amino-1,9-dihydro-6H-purine-6-thione, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | | 著者 | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | | 登録日 | 2015-01-16 | | 公開日 | 2015-08-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.782 Å) | | 主引用文献 | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015
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4XHZ
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