3K4V

New crystal form of HIV-1 Protease/Saquinavir structure reveals carbamylation of N-terminal proline

Summary for 3K4V

• Entry DOI: 10.2210/pdb3k4v/pdb
• Related PRD ID: PRD_000454
• Descriptor: HIV-1 Protease, DIMETHYL SULFOXIDE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, ... (6 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, carbamylation, aids, aspartyl protease, capsid maturation, capsid protein, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 4
• Total formula weight: 44706.43

Authors

Olajuyigbe, F.M.,Demitri, N.,Ajele, J.O.,Maurizio, E.,Randaccio, L.,Geremia, S. (deposition date: 2009-10-06, release date: 2010-06-09, Last modification date: 2023-09-06)

• Primary citation: Olajuyigbe, F.M.,Demitri, N.,Ajele, J.O.,Maurizio, E.,Randaccio, L.,Geremia, S.; Carbamylation of N-terminal proline.; ACS Med Chem Lett, 1:254-257, 2010; PubMed: 24900204; DOI: 10.1021/ml100046d

Experimental method

X-RAY DIFFRACTION (1.39 Å)