PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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2R6M	Crystal structure of rat CK2-beta subunit 分子名称: Casein kinase II subunit beta, ZINC ION 著者 Shen, Y. 登録日 2007-09-06 公開日 2008-09-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structures of catalytic and regulatory subunits of rat protein kinase CK2 CHIN.SCI.BULL., 54, 2009
5LF4	Human 20S proteasome complex with Delanzomib at 2.0 Angstrom 分子名称: CHLORIDE ION, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... 著者 Schrader, J, Henneberg, F, Mata, R, Tittmann, K, Schneider, T.R, Stark, H, Bourenkov, G, Chari, A. 登録日 2016-06-30 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353, 2016
4FSU	Crystal Structure of the CHK1 分子名称: 4-[6-(1H-imidazol-1-ylmethyl)-7-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl]benzonitrile, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. 登録日 2012-06-27 公開日 2012-08-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of the CHK1 To be Published
4FT5	Crystal Structure of the CHK1 分子名称: 1-{5-chloro-2-[(3R)-pyrrolidin-3-yloxy]phenyl}-3-(5-cyanopyrazin-2-yl)urea, GLYCEROL, SULFATE ION, ... 著者 Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. 登録日 2012-06-27 公開日 2012-08-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of the CHK1 To be Published
4FTO	Crystal Structure of the CHK1 分子名称: 4-{7-methoxy-6-[3-(morpholin-4-yl)propoxy]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl}benzonitrile, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. 登録日 2012-06-27 公開日 2012-08-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of the CHK1 To be Published
5LF6	Human 20S proteasome complex with Z-LLY-ketoaldehyde at 2.1 Angstrom 分子名称: CHLORIDE ION, LLY-ketoaldehyde peptide, MAGNESIUM ION, ... 著者 Schrader, J, Henneberg, F, Mata, R, Tittmann, K, Schneider, T.R, Stark, H, Bourenkov, G, Chari, A. 登録日 2016-06-30 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353, 2016
4G1Z	Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor 分子名称: 3-(5'-{[3,4-bis(hydroxymethyl)benzyl]oxy}-2'-ethyl-2-propylbiphenyl-4-yl)pentan-3-ol, Nuclear receptor coactivator 1, Vitamin D3 receptor A 著者 Ciesielski, F, Sato, Y, Moras, D, Rochel, N. 登録日 2012-07-11 公開日 2012-09-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor. J.Med.Chem., 55, 2012
5LEY	Human 20S proteasome complex with Oprozomib at 1.9 Angstrom 分子名称: CHLORIDE ION, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... 著者 Schrader, J, Henneberg, F, Mata, R, Tittmann, K, Schneider, T.R, Stark, H, Bourenkov, G, Chari, A. 登録日 2016-06-30 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353, 2016
3D6H	Crystal structure of human caspase-1 with a naturally-occurring Asn263->Ser substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) 分子名称: Caspase-1, Caspase-1 precursor, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide 著者 Rosen-Wolff, A, Roesler, J, Romanowski, M.J. 登録日 2008-05-19 公開日 2010-03-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008
4GGA	Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C 分子名称: Cell division cycle protein 20 homolog 著者 Luo, X, Tian, W, Tomchick, D.R. 登録日 2012-08-06 公開日 2012-11-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.044 Å) 主引用文献 Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc.Natl.Acad.Sci.USA, 109, 2012
3D7D	A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCFBD, a urea-based inhibitor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Lubkowski, J, Barinka, C. 登録日 2008-05-21 公開日 2008-12-30 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization J.Med.Chem., 51, 2008
3D9J	Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II 分子名称: AMMONIUM ION, GLYCEROL, RNA-binding protein 16, ... 著者 Becker, R, Loll, B, Meinhart, A. 登録日 2008-05-27 公開日 2008-06-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Snapshots of the RNA Processing Factor SCAF8 Bound to Different Phosphorylated Forms of the Carboxyl-terminal Domain of RNA Polymerase II. J.Biol.Chem., 283, 2008
3D9T	CIAP1-BIR3 in complex with N-terminal peptide from Caspase-9 (ATPFQE) 分子名称: Baculoviral IAP repeat-containing protein 2, Caspase-9, ZINC ION 著者 Kulathila, R, Price, A. 登録日 2008-05-27 公開日 2008-06-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. Acta Crystallogr.,Sect.D, 65, 2009
4GB0	Crystal Structure of the RING domain of RNF168 分子名称: E3 ubiquitin-protein ligase RNF168, MALONATE ION, ZINC ION 著者 Zhang, X.Q, Wang, C.L, Zang, J.Y. 登録日 2012-07-26 公開日 2013-07-10 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for role of ring finger protein RNF168 RING domain Cell Cycle, 12, 2013
3D9N	Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II 分子名称: CTD-PEPTIDE, RNA-binding protein 16, SULFATE ION 著者 Becker, R, Loll, B, Meinhart, A. 登録日 2008-05-27 公開日 2008-06-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Snapshots of the RNA Processing Factor SCAF8 Bound to Different Phosphorylated Forms of the Carboxyl-terminal Domain of RNA Polymerase II. J.Biol.Chem., 283, 2008
2TSR	THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE, TOMUDEX 著者 Sotelo-Mundo, R.R, Ciesla, J, Dzik, J.M, Rode, W, Maley, F, Maley, G, Hardy, L.W, Montfort, W.R. 登録日 1998-06-19 公開日 1999-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug. Biochemistry, 38, 1999
4FSY	Crystal Structure of the CHK1 分子名称: 2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-3-yl)benzamide, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Kang, Y.N, Stuckey, J.A, Chang, P, Russell, A.J. 登録日 2012-06-27 公開日 2012-08-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of the CHK1 To be Published
5LF7	Human 20S proteasome complex with Ixazomib at 2.0 Angstrom 分子名称: CHLORIDE ION, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... 著者 Schrader, J, Henneberg, F, Mata, R, Tittmann, K, Schneider, T.R, Stark, H, Bourenkov, G, Chari, A. 登録日 2016-06-30 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353, 2016
3DAI	Crystal structure of the bromodomain of the human ATAD2 分子名称: ATPase family AAA domain-containing protein 2, CHLORIDE ION, SULFATE ION 著者 Filippakopoulos, P, Keates, T, Picaud, S, Fedorov, O, Roos, A.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2008-05-29 公開日 2008-09-09 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
2RVM	Solution structure of the chromodomain of HP1alpha with the phosphorylated N-terminal tail 分子名称: Chromobox protein homolog 5 著者 Kawaguchi, A, Nishimura, Y. 登録日 2015-12-18 公開日 2016-03-16 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Extended string-like binding of the phosphorylated HP1 alpha N-terminal tail to the lysine 9-methylated histone H3 tail Sci Rep, 6, 2016
3DBL	Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190wt-NEDD8Ala72Gln) 分子名称: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ... 著者 Souphron, J, Schulman, B.A. 登録日 2008-06-01 公開日 2008-08-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry, 47, 2008
3DGV	Crystal structure of thrombin activatable fibrinolysis inhibitor (TAFI) 分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Anand, K, Pallares, I, Valnickova, Z, Christensen, T, Schreuder, H, Enghild, J. 登録日 2008-06-16 公開日 2008-07-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The crystal structure of thrombin-activable fibrinolysis inhibitor (TAFI) provides the structural basis for its intrinsic activity and the short half-life of TAFIa. J.Biol.Chem., 283, 2008
2RQK	NMR Solution Structure of Mesoderm Development (MESD) - closed conformation 分子名称: Mesoderm development candidate 2 著者 Koehler, C, Lighthouse, J.K, Werther, T, Andersen, O.M, Diehl, A, Schmieder, P, Holdener, B.C, Oschkinat, H. 登録日 2009-08-06 公開日 2009-08-25 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 The Structure of MESD45-184 Brings Light into the Mechanism of LDLR Family Folding Structure, 19, 2011
2RT9	Solution structure of a regulatory domain of meiosis inhibitor 分子名称: F-box only protein 43, ZINC ION 著者 Shoji, S, Muto, Y, Ikeda, M, He, F, Tsuda, K, Ohsawa, N, Akasaka, R, Terada, T, Wakiyama, M, Shirouzu, M, Yokoyama, S. 登録日 2013-07-05 公開日 2014-07-16 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation FEBS Open Bio, 4, 2014
4G2H	Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor 分子名称: (3E,5E)-6-(3-{2-[3,4-bis(hydroxymethyl)phenyl]ethyl}phenyl)-1,1,1-trifluoro-2-(trifluoromethyl)octa-3,5-dien-2-ol, Nuclear receptor coactivator 1, Vitamin D3 receptor A 著者 Ciesielski, F, Sato, Y, Moras, D, Rochel, N. 登録日 2012-07-12 公開日 2012-09-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor. J.Med.Chem., 55, 2012

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