PDB: 17019 件ウェブページステータス検索Chemie searchBIRD

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5DGM	Crystal structure of human FPPS in complex with monophosphonate compound 7 分子名称: Farnesyl pyrophosphate synthase, PHOSPHATE ION, {2-[(phosphonomethyl)carbamoyl]-1H-benzo[g]indol-1-yl}acetic acid 著者 Rondeau, J.M, Bourgier, E, Lehmann, S. 登録日 2015-08-28 公開日 2016-07-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 A General Strategy for Targeting Drugs to Bone. Angew.Chem.Int.Ed.Engl., 54, 2015
5DIQ	Crystal structure of human FPPS in complex with salicylic acid derivative 3a 分子名称: 2-(naphthalen-1-ylmethoxy)benzoic acid, Farnesyl pyrophosphate synthase, GLYCEROL, ... 著者 Rondeau, J.M, Bourgier, E, Lehmann, S. 登録日 2015-09-01 公開日 2015-09-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
5DJP	Crystal structure of human FPPS in complex with biaryl compound 5 分子名称: 4-(naphthalen-1-yl)-1H-indole-2-carboxylic acid, Farnesyl pyrophosphate synthase, PHOSPHATE ION 著者 Rondeau, J.M, Bourgier, E, Lehmann, S. 登録日 2015-09-02 公開日 2015-09-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
5DJV	Crystal structure of human FPPS in complex with biaryl compound 8e 分子名称: 8-(naphthalen-1-yl)-6-(1H-pyrrol-2-yl)quinoline-2-carboxylic acid, Farnesyl pyrophosphate synthase 著者 Rondeau, J.M, Bourgier, E, Lehmann, S. 登録日 2015-09-02 公開日 2015-10-07 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
5DJR	Crystal structure of human FPPS in complex with biaryl compound 6 分子名称: 1H,1'H-4,4'-biindole-2-carboxylic acid, Farnesyl pyrophosphate synthase, GLYCEROL, ... 著者 Rondeau, J.M, Bourgier, E, Lehmann, S. 登録日 2015-09-02 公開日 2015-09-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
4G80	Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (WT, 3.8 A) 分子名称: Voltage-sensor containing phosphatase, fragment antibody heavy chain, fragment antibody light chain 著者 Li, Q. 登録日 2012-07-20 公開日 2014-02-05 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.58 Å) 主引用文献 Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain. Nat. Struct. Mol. Biol., 21, 2014
5M5J	Thioredoxin reductase from Giardia duodenalis 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, SODIUM ION, Thioredoxin reductase 著者 Fiorillo, A, Ilari, A, Lalle, M. 登録日 2016-10-21 公開日 2017-05-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX. Eur J Med Chem, 135, 2017
4G7V	Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.5 A) 分子名称: CHLORIDE ION, LAURYL DIMETHYLAMINE-N-OXIDE, SUCCINIC ACID, ... 著者 Li, Q. 登録日 2012-07-20 公開日 2014-02-05 最終更新日 2017-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain. Nat. Struct. Mol. Biol., 21, 2014
2FFL	Crystal Structure of Dicer from Giardia intestinalis 分子名称: Dicer, MANGANESE (II) ION 著者 Doudna, J.A, MacRae, I.J, Adams, P.D. 登録日 2005-12-19 公開日 2006-01-24 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.33 Å) 主引用文献 Structural Basis of Double-Stranded RNA Processing by Dicer Science, 311, 2006
3PF3	Crystal structure of a mutant (C202A) of Triosephosphate isomerase from Giardia lamblia derivatized with MMTS 分子名称: CALCIUM ION, GLYCEROL, SULFATE ION, ... 著者 Enriquez-Flores, S, Rodriguez-Romero, A, Hernandez-Santoyo, A, Reyes-Vivas, H. 登録日 2010-10-27 公開日 2011-06-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.098 Å) 主引用文献 Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: A study for antiparasitic drug design. Proteins, 79, 2011
4F7R	Crystal structure of 14-3-3 protein from Giardia intestinalis 分子名称: 14-3-3 protein, SULFATE ION 著者 Fiorillo, A, Ilari, A, Lalle, M. 登録日 2012-05-16 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The Crystal Structure of Giardia duodenalis 14-3-3 in the Apo Form: When Protein Post-Translational Modifications Make the Difference. Plos One, 9, 2014
2II2	Crystal Structure of Alpha-11 Giardin 分子名称: Alpha-11 giardin, SULFATE ION 著者 Pathuri, P, Nguyen, E.T, Luecke, H. 登録日 2006-09-27 公開日 2007-04-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Apo and Calcium-bound Crystal Structures of Alpha-11 Giardin, an Unusual Annexin from Giardia lamblia J.Mol.Biol., 368, 2007
2IIC	Calcium bound structure of alpha-11 giardin 分子名称: Alpha-11 giardin, CALCIUM ION 著者 Pathuri, P, Nguyen, E.T, Luecke, H. 登録日 2006-09-27 公開日 2007-04-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Apo and Calcium-bound Crystal Structures of Alpha-11 Giardin, an Unusual Annexin from Giardia lamblia J.Mol.Biol., 368, 2007
3ZQT	TARGETING THE BINDING FUNCTION 3 SITE OF THE ANDROGEN RECEPTOR THROUGH IN SILICO MOLECULAR MODELING 分子名称: 4-[(2R,3S)-3-[(3,4-DIHYDROXYPHENYL)METHYL]-2-METHYLBUTYL]BENZENE-1,2-DIOL, ANDROGEN RECEPTOR, SULFATE ION, ... 著者 Lack, N.A, Axerio, P, Tavassoli, P, Kuchenbecker, K, Han, F.Q, Chan, K.H, Feau, C, LeBlanc, E, Tomlinson, E, Guy, R.K, Rennie, P.S, Cherkasov, A. 登録日 2011-06-10 公開日 2011-12-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Targeting the Binding Function 3 (Bf3) Site of the Human Androgen Receptor Through Virtual Screening. J.Med.Chem., 54, 2011
5DGN	Crystal structure of human FPPS in complex with compound 13 分子名称: 8-(naphthalen-1-yl)quinoline-2-carboxylic acid, Farnesyl pyrophosphate synthase 著者 Rondeau, J.M, Bourgier, E, Lehmann, S. 登録日 2015-08-28 公開日 2015-09-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
4MGS	BiXyn10A CBM1 APO 分子名称: Putative glycosyl hydrolase family 10 著者 Chekan, J.R, Nair, S.K. 登録日 2013-08-28 公開日 2014-08-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Xylan utilization in human gut commensal bacteria is orchestrated by unique modular organization of polysaccharide-degrading enzymes. Proc.Natl.Acad.Sci.USA, 111, 2014
4HLW	Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor Through Virtual Screening. 2. Development of 2-((2-phenoxyethyl) thio)-1H-benzoimidazole derivatives. 分子名称: 2-[(2-phenoxyethyl)sulfanyl]-1H-benzimidazole, Androgen receptor, GLYCEROL, ... 著者 Ravi, S.N.M, Leblanc, E, Axerio-Cilies, P, Labriere, C, Frewin, K, Hassona, M.D.H, Lack, N.A, Han, F.Q, Guns, E.S, Young, R, Ban, F, Rennie, P.S, Cherkasov, A. 登録日 2012-10-17 公開日 2013-01-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Targeting the Binding Function 3 (BF3) Site of the Androgen Receptor Through Virtual Screening. 2. Development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole Derivatives. J.Med.Chem., 56, 2013
5LDY	Structure of Yersinia pseudotuberculosis InvD 分子名称: Ig domain protein group 1 domain protein, PHOSPHATE ION 著者 Sadana, P, Scrima, A. 登録日 2016-06-28 公開日 2017-06-14 最終更新日 2020-06-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine J.Biol.Chem., 2018
5LS9	Humanized Archaeal ferritin 分子名称: Ferritin, putative, MAGNESIUM ION 著者 Baiocco, P, Trabuco, M.C, Boffi, A. 登録日 2016-08-23 公開日 2016-11-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Humanized archaeal ferritin as a tool for cell targeted delivery. Nanoscale, 9, 2017
4EVH	Crystal structure of calcium-bound alpha-1 giardin 分子名称: CALCIUM ION, Giardin subunit alpha-1 著者 Weeratunga, S, Hofmann, A. 登録日 2012-04-26 公開日 2012-07-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms J.Mol.Biol., 423, 2012
4EVF	Crystal structure of apo alpha-1 giardin 分子名称: Giardin subunit alpha-1 著者 Weeratunga, S, Hofmann, A. 登録日 2012-04-26 公開日 2012-07-25 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms J.Mol.Biol., 423, 2012
3N46	Human FPPS complex with NOV_980 and zoledronic acid/MG2+ 分子名称: (2R)-1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid, FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, ... 著者 Rondeau, J.-M. 登録日 2010-05-21 公開日 2010-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat.Chem.Biol., 6, 2010
2GSA	CRYSTAL STRUCTURE OF GLUTAMATE-1-SEMIALDEHYDE AMINOMUTASE (AMINOTRANSFERASE, WILD-TYPE FORM) 分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLUTAMATE SEMIALDEHYDE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE 著者 Hennig, M, Jansonius, J.N. 登録日 1997-02-26 公開日 1998-03-04 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity. Proc.Natl.Acad.Sci.USA, 94, 1997
3N1V	Human FPPS COMPLEX WITH FBS_01 分子名称: (5-chloro-3-methyl-1-benzothiophen-2-yl)acetic acid, FARNESYL PYROPHOSPHATE SYNTHASE, PHOSPHATE ION 著者 Rondeau, J.-M. 登録日 2010-05-17 公開日 2010-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat.Chem.Biol., 6, 2010
3N49	Human FPPS COMPLEX WITH NOV_292 分子名称: FARNESYL PYROPHOSPHATE SYNTHASE, PHOSPHATE ION, naphtho[2,1-b]thiophen-1-ylacetic acid 著者 Rondeau, J.-M. 登録日 2010-05-21 公開日 2010-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat.Chem.Biol., 6, 2010

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