3N1V
Human FPPS COMPLEX WITH FBS_01
Summary for 3N1V
| Entry DOI | 10.2210/pdb3n1v/pdb |
| Related | 3N1W 3N3L 3N45 3N46 3N49 3N5H 3N5J 3N6K |
| Descriptor | FARNESYL PYROPHOSPHATE SYNTHASE, (5-chloro-3-methyl-1-benzothiophen-2-yl)acetic acid, PHOSPHATE ION, ... (4 entities in total) |
| Functional Keywords | bisphosphonate; fragment-based screening; transferase; isoprene biosynthesis; cholesterol biosynthesis, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P14324 |
| Total number of polymer chains | 1 |
| Total formula weight | 40760.24 |
| Authors | Rondeau, J.-M. (deposition date: 2010-05-17, release date: 2010-08-18, Last modification date: 2024-02-21) |
| Primary citation | Jahnke, W.,Rondeau, J.M.,Cotesta, S.,Marzinzik, A.,Pelle, X.,Geiser, M.,Strauss, A.,Gotte, M.,Bitsch, F.,Hemmig, R.,Henry, C.,Lehmann, S.,Glickman, J.F.,Roddy, T.P.,Stout, S.J.,Green, J.R. Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat.Chem.Biol., 6:660-666, 2010 Cited by PubMed: 20711197DOI: 10.1038/nchembio.421 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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