Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3N45

Human FPPS complex with FBS_04 and zoledronic acid/MG2+

Summary for 3N45
Entry DOI10.2210/pdb3n45/pdb
Related3N1V 3N1W 3N3L 3N46 3N49 3N5H 3N5J 3N6K
DescriptorFARNESYL PYROPHOSPHATE SYNTHASE, (2S)-1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid, ZOLEDRONIC ACID, ... (6 entities in total)
Functional Keywordsbisphosphonate; fragment-based screening; transferase; isoprene biosynthesis; cholesterol biosynthesis, transferase, transferase-transferase inhibiator complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P14324
Total number of polymer chains1
Total formula weight41016.11
Authors
Rondeau, J.-M. (deposition date: 2010-05-21, release date: 2010-08-18, Last modification date: 2024-02-21)
Primary citationJahnke, W.,Rondeau, J.M.,Cotesta, S.,Marzinzik, A.,Pelle, X.,Geiser, M.,Strauss, A.,Gotte, M.,Bitsch, F.,Hemmig, R.,Henry, C.,Lehmann, S.,Glickman, J.F.,Roddy, T.P.,Stout, S.J.,Green, J.R.
Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.
Nat.Chem.Biol., 6:660-666, 2010
Cited by
PubMed: 20711197
DOI: 10.1038/nchembio.421
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.88 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon