5CSB
 
 | | The crystal structure of beta2-microglobulin D76N mutant at room temperature | | 分子名称: | Beta-2-microglobulin | | 著者 | de Rosa, M, Mota, C.S, de Sanctis, D, Bolognesi, M, Ricagno, S. | | 登録日 | 2015-07-23 | | 公開日 | 2016-08-10 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.719 Å) | | 主引用文献 | Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.
Nat Commun, 9, 2018
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5D7L
 | | Structure of human MR1-5-OP-RU in complex with human MAV36 TCR | | 分子名称: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, Beta-2-microglobulin, MAV36 TCR Alpha Chain, ... | | 著者 | Keller, A.N, Rossjohn, J. | | 登録日 | 2015-08-14 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition.
Immunity, 44, 2016
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6EXZ
 | | Crystal structure of Mex67 C-term | | 分子名称: | FORMIC ACID, mRNA export factor MEX67 | | 著者 | Mohamad, N, Bravo, J. | | 登録日 | 2017-11-10 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Mip6 binds directly to the Mex67 UBA domain to maintain low levels of Msn2/4 stress-dependent mRNAs.
Embo Rep., 2019
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7P7R
 | | PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state I | | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | 著者 | Crowe-McAuliffe, C, Wilson, D.N. | | 登録日 | 2021-07-20 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
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5CS7
 | | The crystal structure of wt beta2-microglobulin at room temperature | | 分子名称: | Beta-2-microglobulin | | 著者 | de Rosa, M, Mota, C.S, de Sanctis, D, Bolognesi, M, Ricagno, S. | | 登録日 | 2015-07-23 | | 公開日 | 2016-08-10 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.
Nat Commun, 9, 2018
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7S5A
 | | Crystal structure of human chemokine CCL8 | | 分子名称: | C-C motif chemokine 8 | | 著者 | Bhusal, R.P, Devkota, S.R, Aryal, P, Wilce, M.C.J, Stone, M.J. | | 登録日 | 2021-09-10 | | 公開日 | 2021-09-29 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | | 主引用文献 | Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases.
Proc.Natl.Acad.Sci.USA, 119, 2022
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9L2E
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5D90
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5D2L
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9N3R
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9N3N
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9N3O
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9N3Q
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9MGM
 | | Crystal structure of PRMT5:MEP50 in complex with MTA and compound 24 | | 分子名称: | 2-(cyclobutylamino)-N-[(2S)-2-hydroxy-3-{6-[(1-methyl-1H-pyrazol-5-yl)methoxy]-3,4-dihydroisoquinolin-2(1H)-yl}propyl]pyridine-4-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... | | 著者 | Whittington, D.A. | | 登録日 | 2024-12-11 | | 公開日 | 2025-03-05 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design.
J.Med.Chem., 68, 2025
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9N3P
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9L2D
 | | Structure of SARM1 bound to M1 in the intermediate state 1 | | 分子名称: | NAD(+) hydrolase SARM1, [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate | | 著者 | Huang, Y, Zhang, J, Zheng, S, Wang, X. | | 登録日 | 2024-12-17 | | 公開日 | 2025-03-12 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | Stepwise Activation of SARM1 by a Biosynthetic NMN mimic
To Be Published
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5D7I
 | | Structure of human MR1-Ac-6-FP in complex with human MAIT M33.64 TCR | | 分子名称: | Beta-2-microglobulin, GLYCEROL, M33.64 TCR Alpha Chain, ... | | 著者 | Keller, A.N, Woolley, R.E, Rossjohn, J. | | 登録日 | 2015-08-14 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition.
Immunity, 44, 2016
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9MGL
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9MGP
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5D0B
 | | Crystal structure of epoxyqueuosine reductase with a tRNA-TYR epoxyqueuosine-modified tRNA stem loop | | 分子名称: | COBALAMIN, Epoxyqueuosine reductase, GLYCEROL, ... | | 著者 | Dowling, D.P, Miles, Z.D, Kohrer, C, Bandarian, V, Drennan, C.L. | | 登録日 | 2015-08-03 | | 公開日 | 2016-09-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.645 Å) | | 主引用文献 | Molecular basis of cobalamin-dependent RNA modification.
Nucleic Acids Res., 44, 2016
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9L2G
 | | Structure of SARM1 2C-mutant bound to M1 | | 分子名称: | NAD(+) hydrolase SARM1, [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate | | 著者 | Huang, Y, Zhang, J, Zheng, S, Wang, X. | | 登録日 | 2024-12-17 | | 公開日 | 2025-03-19 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Stepwise Activation of SARM1 by a Biosynthetic NMN mimic
To Be Published
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5D5M
 | | Structure of human MR1-5-OP-RU in complex with human MAIT M33.64 TCR | | 分子名称: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, ACETATE ION, Beta-2-microglobulin, ... | | 著者 | Keller, A.N, Birkinshaw, R.W, Rossjohn, J. | | 登録日 | 2015-08-11 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition.
Immunity, 44, 2016
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9L2F
 | | Structure of SARM1 bound to M1 and 1AD in the active state | | 分子名称: | NAD(+) hydrolase SARM1, [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate | | 著者 | Huang, Y, Zhang, J, Zheng, S, Wang, X. | | 登録日 | 2024-12-17 | | 公開日 | 2025-03-19 | | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | | 主引用文献 | Stepwise Activation of SARM1 by a Biosynthetic NMN mimic
To Be Published
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5D8C
 | | Crystal structure of HiNmlR, a MerR family regulator lacking the sensor domain, bound to promoter DNA | | 分子名称: | DNA (5'-D(*CP*TP*TP*AP*GP*AP*GP*TP*GP*AP*AP*CP*TP*CP*TP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*AP*GP*AP*GP*TP*TP*CP*AP*CP*TP*CP*TP*AP*AP*G)-3'), MerR family regulator protein | | 著者 | Counago, R.M, Chang, C.W, Chen, N.H, Djoko, K.Y, McEwan, A.G, Kobe, B. | | 登録日 | 2015-08-17 | | 公開日 | 2016-06-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region.
Nucleic Acids Res., 44, 2016
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4Y2A
 | | Crystal Structure of Coxsackie Virus B3 3D polymerase in complex with GPC-N114 inhibitor | | 分子名称: | 2,2'-[(4-chlorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... | | 著者 | Vives-Adrian, L, Ferrer-Orta, C, Verdaguer, N. | | 登録日 | 2015-02-09 | | 公開日 | 2015-04-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
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