PDB: 974 件ウェブページステータス検索Chemie searchBIRD

---

4JPM	Structure of SHV-1 beta-lactamase in complex with the 7-alkylidenecephalosporin DCM-1-10 at 1.14 Ang resolution 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 7-alkylidenecephalosporin DCM-1-10, bound form, ... 著者 Rodkey, E.A, van den Akker, F. 登録日 2013-03-19 公開日 2013-12-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.14 Å) 主引用文献 beta-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-Enzyme. J.Am.Chem.Soc., 135, 2013
4JLF	Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase 分子名称: Beta-lactamase, PHOSPHATE ION 著者 Hazra, S, Kurz, S, Blanchard, J, Bonomo, R. 登録日 2013-03-12 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations. Antimicrob.Agents Chemother., 57, 2013
4LEN	CTX-M-9 in complex with the broad spectrum inhibitor 3-(2- carboxyvinyl)benzo(b)thiophene-2-boronic acid 分子名称: (2E)-3-[2-(dihydroxyboranyl)-1-benzothiophen-3-yl]prop-2-enoic acid, Beta-lactamase 著者 Tondi, D. 登録日 2013-06-26 公開日 2014-06-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Targeting Class A and C Serine beta-Lactamases with a Broad-Spectrum Boronic Acid Derivative. J.Med.Chem., 57, 2014
3TOI	Tailoring Enzyme Stability and Exploiting Stability-Trait Linkage by Iterative Truncation and Optimization 分子名称: Ampicillin resistance protein 著者 Tam, H.K, Einsle, O. 登録日 2011-09-05 公開日 2012-05-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Exploring the Molecular Linkage of Protein Stability Traits for Enzyme Optimization by Iterative Truncation and Evolution. Biochemistry, 51, 2012
3RXW	KPC-2 carbapenemase in complex with PSR3-226 分子名称: (2S,3R)-4-(2-amino-2-oxoethoxy)-3-(dihydroxy-lambda~4~-sulfanyl)-3-methyl-4-oxo-2-{[(1E)-3-oxoprop-1-en-1-yl]amino}butanoic acid, CITRIC ACID, Carbepenem-hydrolyzing beta-lactamase KPC 著者 Ke, W, van den Akker, F. 登録日 2011-05-10 公開日 2012-03-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Crystal structures of KPC-2 {beta}-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226. Antimicrob.Agents Chemother., 56, 2012
3RXX	KPC-2 carbapenemase in complex with 3-NPBA 分子名称: 3-NITROPHENYLBORONIC ACID, Carbepenem-hydrolyzing beta-lactamase KPC 著者 Ke, W, van den Akker, F. 登録日 2011-05-10 公開日 2012-03-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Crystal structures of KPC-2 {beta}-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226. Antimicrob.Agents Chemother., 56, 2012
3V3S	Crystal structure of GES-18 分子名称: Extended spectrum beta-lactamase GES-18 著者 Delbruck, H, Hoffmann, K.M.V, Bebrone, C. 登録日 2011-12-14 公開日 2012-11-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 GES-18, a new carbapenem-hydrolyzing GES-Type beta-lactamase from pseudomonas aeruginosa that contains Ile80 and Ser170 residues. Antimicrob.Agents Chemother., 57, 2013
3V3R	Crystal Structure of GES-11 分子名称: Extended spectrum class A beta-lactamase GES-11, IODIDE ION, SODIUM ION 著者 Delbruck, H, Hoffmann, K.M.V, Bebrone, C. 登録日 2011-12-14 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.898 Å) 主引用文献 Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 beta-lactamases. Antimicrob.Agents Chemother., 56, 2012
3V50	Complex of SHV S130G mutant beta-lactamase complexed to SA2-13 分子名称: (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, Beta-lactamase, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE 著者 Wei, K, van den Akker, F. 登録日 2011-12-15 公開日 2012-08-08 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The importance of the trans-enamine intermediate as a beta-lactamase inhibition strategy probed in inhibitor-resistant SHV beta-lactamase variants. Chemmedchem, 7, 2012
3VFH	BlaC E166A CDC-1 Acyl-Intermediate 分子名称: (2R)-5-methylidene-2-{(1R)-2-oxo-1-[(phenylacetyl)amino]ethyl}-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION 著者 Mire, J.A, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2012-01-09 公開日 2012-09-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 BlaC-Specific Fluorogenic Probes for Rapid Tuberculosis Detection To be Published
3VFF	BlaC E166A CDC-OMe Acyl-Intermediate Complex 分子名称: (2R)-2-[(1S)-1-(benzoylamino)-1-methoxy-2-oxoethyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION 著者 Mire, J.A, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2012-01-09 公開日 2012-09-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.777 Å) 主引用文献 BlaC-Specific Fluorogenic Probes for Rapid Tuberculosis Detection To be Published
3V5M	Crystal structure of M69V mutant of SHV beta-lactamase 分子名称: Beta-lactamase, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE 著者 van den Akker, F, Rodkey, E.A. 登録日 2011-12-16 公開日 2012-08-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The importance of the trans-enamine intermediate as a beta-lactamase inhibition strategy probed in inhibitor-resistant SHV beta-lactamase variants. Chemmedchem, 7, 2012
3TSG	Crystal structure of GES-14 分子名称: Extended-spectrum beta-lactamase GES-14, GLYCEROL, IODIDE ION 著者 Delbruck, H, Hoffmann, K.M.V, Bebrone, C. 登録日 2011-09-13 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 beta-lactamases. Antimicrob.Agents Chemother., 56, 2012
3W4P	Crystal structure of PenI beta-lactamase from Burkholderia pseudomallei at pH7.5 分子名称: Beta-lactamase, GLYCEROL, SULFATE ION 著者 Nukaga, M, Ohuchi, N, Papp-Wallace, K.M, Taracila, M.A, Bonomo, R.A. 登録日 2013-01-10 公開日 2013-05-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Insights into beta-lactamases from Burkholderia species, two phylogenetically related yet distinct resistance determinants J.Biol.Chem., 288, 2013
3W4Q	Crystal structure of PenA beta-lactamase from Burkholderia multivorans at pH4.2 分子名称: Beta-lactamase 著者 Nukaga, M, Ohuchi, N, Papp-Wallace, K.M, Taracila, M.A, Bonomo, R.A. 登録日 2013-01-10 公開日 2013-05-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Insights into beta-lactamases from Burkholderia species, two phylogenetically related yet distinct resistance determinants J.Biol.Chem., 288, 2013
1ESU	S235A MUTANT OF TEM1 BETA-LACTAMASE 分子名称: BETA-LACTAMASE, SULFATE ION 著者 Fonze, E, Charlier, P. 登録日 2000-04-11 公開日 2000-05-03 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 TEM1 beta-lactamase structure solved by molecular replacement and refined structure of the S235A mutant. Acta Crystallogr.,Sect.D, 51, 1995
1ERO	X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID 分子名称: (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID, TEM-1 BETA-LACTAMASE 著者 Ness, S, Martin, R, Kindler, A.M, Paetzel, M, Gold, M, Jones, J.B, Strynadka, N.C.J. 登録日 2000-04-06 公開日 2000-05-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,). Biochemistry, 39, 2000
3E2K	Crystal Structure of the KPC-2 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) 分子名称: Beta-lactamase inhibitory protein, Carbapenemase 著者 Hanes, M.S, Jude, K.M, Berger, J.M, Bonomo, R.A, Handel, T.M. 登録日 2008-08-05 公開日 2009-08-04 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein Biochemistry, 48, 2009
3G31	CTX-M-9 class A beta-lactamase complexed with compound 4 (GF1) 分子名称: (2S)-2-[(3aR,4R,7S,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl]propanoic acid, Beta-lactamase CTX-M-9a, DIMETHYL SULFOXIDE, ... 著者 Chen, Y, Shoichet, B.K. 登録日 2009-02-01 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular docking and ligand specificity in fragment-based inhibitor discovery Nat.Chem.Biol., 5, 2009
3G30	CTX-M-9 class A beta-lactamase complexed with compound 3 (G30) 分子名称: (1S,2R)-2-[(2,5-difluorophenyl)carbamoyl]cyclopropanecarboxylic acid, Beta-lactamase CTX-M-9a 著者 Chen, Y, Shoichet, B.K. 登録日 2009-02-01 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Molecular docking and ligand specificity in fragment-based inhibitor discovery Nat.Chem.Biol., 5, 2009
3G2Y	CTX-M-9 class A beta-lactamase complexed with compound 1 (GF4) 分子名称: 4-ethyl-5-methyl-2-(1H-tetrazol-5-yl)-1,2-dihydro-3H-pyrazol-3-one, Beta-lactamase CTX-M-9a, DIMETHYL SULFOXIDE 著者 Chen, Y, Shoichet, B.K. 登録日 2009-02-01 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Molecular docking and ligand specificity in fragment-based inhibitor discovery Nat.Chem.Biol., 5, 2009
3G32	CTX-M-9 class A beta-lactamase complexed with compound 6 (3G3) 分子名称: 2-[2-(1H-tetrazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione, Beta-lactamase CTX-M-9a, DIMETHYL SULFOXIDE, ... 著者 Chen, Y, Shoichet, B.K. 登録日 2009-02-01 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Molecular docking and ligand specificity in fragment-based inhibitor discovery Nat.Chem.Biol., 5, 2009
1FQG	MOLECULAR STRUCTURE OF THE ACYL-ENZYME INTERMEDIATE IN TEM-1 BETA-LACTAMASE 分子名称: OPEN FORM - PENICILLIN G, TEM-1 BETA-LACTAMASE 著者 Strynadka, N.C. 登録日 2000-09-05 公開日 2000-11-01 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution. Nature, 359, 1992
3G34	CTX-M-9 class A beta-lactamase complexed with compound 11 (1CE) 分子名称: 3-(1H-tetrazol-5-ylmethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one, Beta-lactamase CTX-M-9a, DIMETHYL SULFOXIDE, ... 著者 Chen, Y, Shoichet, B.K. 登録日 2009-02-01 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Molecular docking and ligand specificity in fragment-based inhibitor discovery Nat.Chem.Biol., 5, 2009
3G2Z	CTX-M-9 class A beta-lactamase complexed with compound 2 (GZ2) 分子名称: 3-(1H-tetrazol-5-ylamino)cyclohex-2-en-1-one, Beta-lactamase CTX-M-9a, DIMETHYL SULFOXIDE 著者 Chen, Y, Shoichet, B.K. 登録日 2009-02-01 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Molecular docking and ligand specificity in fragment-based inhibitor discovery Nat.Chem.Biol., 5, 2009

<24252627282930313233343536373839>