7YYM
| Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate | 分子名称: | 59-nt precursor of miR-15a, Endoribonuclease Dicer | 著者 | Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. | 登録日 | 2022-02-18 | 公開日 | 2022-11-16 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.19 Å) | 主引用文献 | Structural and functional basis of mammalian microRNA biogenesis by Dicer. Mol.Cell, 82, 2022
|
|
1MK2
| SMAD3 SBD complex | 分子名称: | ACETIC ACID, Madh-interacting protein, SMAD 3 | 著者 | Qin, B.Y, Lam, S.S, Correia, J.J, Lin, K. | 登録日 | 2002-08-28 | 公開日 | 2002-10-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control Genes Dev., 16, 2002
|
|
6DXB
| |
1MOM
| CRYSTAL STRUCTURE OF MOMORDIN, A TYPE I RIBOSOME INACTIVATING PROTEIN FROM THE SEEDS OF MOMORDICA CHARANTIA | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MOMORDIN | 著者 | Husain, J, Tickle, I.J, Wood, S.P. | 登録日 | 1994-03-04 | 公開日 | 1994-05-31 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Crystal structure of momordin, a type I ribosome inactivating protein from the seeds of Momordica charantia. FEBS Lett., 342, 1994
|
|
1MPU
| Crystal Structure of the free human NKG2D immunoreceptor | 分子名称: | NKG2-D type II integral membrane protein, PHOSPHATE ION | 著者 | McFarland, B.J, Kortemme, T, Baker, D, Strong, R.K. | 登録日 | 2002-09-12 | 公開日 | 2003-04-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Symmetry Recognizing Asymmetry: Analysis of the Interactions between the C-Type Lectin-like Immunoreceptor NKG2D and MHC
Class I-like Ligands Structure, 11, 2003
|
|
4XGM
| |
1MZN
| CRYSTAL STRUCTURE at 1.9 ANGSTROEMS RESOLUTION OF THE HOMODIMER OF HUMAN RXR ALPHA LIGAND BINDING DOMAIN BOUND TO THE SYNTHETIC AGONIST COMPOUND BMS 649 AND A COACTIVATOR PEPTIDE | 分子名称: | 4-[2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-[1,3]DIOXOLAN-2-YL]-BENZOIC ACID, Nuclear receptor coactivator 2, RXR retinoid X receptor | 著者 | Egea, P.F, Mitschler, A, Moras, D. | 登録日 | 2002-10-09 | 公開日 | 2002-10-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular Recognition of Agonist Ligands by RXRs MOL.ENDOCRINOL., 16, 2002
|
|
1N2L
| Crystal structure of a covalent intermediate of endogenous human arylsulfatase A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ARYLSULFATASE A, ... | 著者 | Chruszcz, M, Laidler, P, Monkiewicz, M, Ortlund, E, Lebioda, L, Lewinski, K. | 登録日 | 2002-10-23 | 公開日 | 2003-12-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structure of a covalent intermediate of endogenous human arylsulfatase A. J.Inorg.Biochem., 96, 2003
|
|
5AOB
| The structure of a novel thermophilic esterase from the Planctomycetes species, Thermogutta terrifontis, Est2-butyrate bound | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Sayer, C, Szabo, Z, Isupov, M.N, Ingham, C, Littlechild, J.A. | 登録日 | 2015-09-10 | 公開日 | 2015-12-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | The Structure of a Novel Thermophilic Esterase from the Planctomycetes Species, Thermogutta Terrifontis Reveals an Open Active Site due to a Minimal 'CAP' Domain. Front.Microbiol., 6, 2015
|
|
1MX8
| |
1N0N
| Catalytic and Structural Effects of Amino-Acid Substitution at His30 in Human Manganese Superoxide Dismutase | 分子名称: | MANGANESE (II) ION, SULFATE ION, Superoxide dismutase [Mn] | 著者 | Borgstahl, G.E.O, Parge, H.E, Hickey, M.J, Beyer Jr, W.F, Hallewell, R.A, Tainer, J.A. | 登録日 | 2002-10-14 | 公開日 | 2002-11-06 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Catalytic and Structural Effects of Amino-Acid Substitution at His30 in Human Manganese Superoxide Dismutase to be published
|
|
7Z2M
| |
1U7T
| Crystal Structure of ABAD/HSD10 with a Bound Inhibitor | 分子名称: | 1-AZEPAN-1-YL-2-PHENYL-2-(4-THIOXO-1,4-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-5-YL)ETHANONE ADDUCT, 3-hydroxyacyl-CoA dehydrogenase type II, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Kissinger, C.R, Rejto, P.A, Pelletier, L.A, Showalter, R.E, Villafranca, J.E. | 登録日 | 2004-08-04 | 公開日 | 2004-10-05 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics J.Mol.Biol., 342, 2004
|
|
6DXU
| |
1U9E
| CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-397 | 分子名称: | 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL, Estrogen receptor beta, STEROID RECEPTOR COACTIVATOR-1 | 著者 | Manas, E.S, Unwalla, R.J, Xu, Z.B, Malamas, M.S, Miller, C.P, Harris, H.A, Hsiao, C, Akopian, T, Hum, W.T, Malakian, K, Wolfrom, S, Bapat, A, Bhat, R.A, Stahl, M.L, Somers, W.S, Alvarez, J.C. | 登録日 | 2004-08-09 | 公開日 | 2005-03-01 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure-Based Design Of Estrogen Receptor-beta Selective Ligands J.Am.Chem.Soc., 126, 2004
|
|
1N28
| Crystal structure of the H48Q mutant of human group IIA phospholipase A2 | 分子名称: | CALCIUM ION, Phospholipase A2, membrane associated | 著者 | Edwards, S.H, Thompson, D, Baker, S.F, Wood, S.P, Wilton, D.C. | 登録日 | 2002-10-22 | 公開日 | 2003-10-28 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism Biochemistry, 41, 2002
|
|
1AGW
| |
5I7C
| Centrosomin-motif 2 (CM2) domain of Drosophila melanogaster Centrosomin (Cnn) | 分子名称: | Centrosomin, ZINC ION | 著者 | Feng, Z, Cottee, M.A, Johnson, S, Lea, S.M. | 登録日 | 2016-02-17 | 公開日 | 2017-03-08 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.804 Å) | 主引用文献 | Structural Basis for Mitotic Centrosome Assembly in Flies. Cell, 169, 2017
|
|
6DZ3
| Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol | 分子名称: | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl]sulfanyl}methyl)pyrrolidin-3-ol, 1,2-ETHANEDIOL, ACETIC ACID, ... | 著者 | Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. | 登録日 | 2018-07-02 | 公開日 | 2019-03-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem., 62, 2019
|
|
6DZ0
| Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((pent-4-yn-1-ylthio)methyl)pyrrolidin-3-ol | 分子名称: | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(pent-4-yn-1-yl)sulfanyl]methyl}pyrrolidin-3-ol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. | 登録日 | 2018-07-02 | 公開日 | 2019-03-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem., 62, 2019
|
|
1TV0
| Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells | 分子名称: | Cryptdin-4 | 著者 | Jing, W, Hunter, H.N, Tanabe, H, Ouellette, A.J, Vogel, H.J. | 登録日 | 2004-06-25 | 公開日 | 2005-01-04 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of Cryptdin-4, a Mouse Paneth Cell alpha-Defensin. Biochemistry, 43, 2004
|
|
5IQQ
| |
6DYZ
| Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((prop-2-yn-1-ylthio)methyl)pyrrolidin-3-ol | 分子名称: | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(prop-2-yn-1-yl)sulfanyl]methyl}pyrrolidin-3-ol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. | 登録日 | 2018-07-02 | 公開日 | 2019-03-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem., 62, 2019
|
|
1MVC
| Crystal structure of the human RXR alpha ligand binding domain bound to the synthetic agonist compound BMS 649 and a coactivator peptide | 分子名称: | 4-[2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-[1,3]DIOXOLAN-2-YL]-BENZOIC ACID, Nuclear receptor coactivator 2, RXR retinoid X receptor | 著者 | Egea, P.F, Mitschler, A, Moras, D. | 登録日 | 2002-09-24 | 公開日 | 2002-10-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular Recognition of Agonist Ligands by RXRs MOL.ENDOCRINOL., 16, 2002
|
|
6DZ2
| Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-benzyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol | 分子名称: | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[3-(1-benzyl-1H-1,2,3-triazol-4-yl)propyl]sulfanyl}methyl)pyrrolidin-3-ol, 1,2-ETHANEDIOL, ACETIC ACID, ... | 著者 | Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. | 登録日 | 2018-07-02 | 公開日 | 2019-03-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem., 62, 2019
|
|