PDB: 37044 件ウェブページステータス検索Chemie searchBIRD

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4Q80	Neutrophil serine protease 4 (PRSS57) with val-leu-lys-chloromethylketone (VLK-cmk) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-valyl-N-[(2S,3S)-7-amino-1-chloro-2-hydroxyheptan-3-yl]-L-leucinamide, ... 著者 Eigenbrot, C, Lin, S.J, Dong, K.C. 登録日 2014-04-25 公開日 2014-09-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.07 Å) 主引用文献 Structures of neutrophil serine protease 4 reveal an unusual mechanism of substrate recognition by a trypsin-fold protease. Structure, 22, 2014
4Q7Y	Neutrophil serine protease 4 (PRSS57) apo form 2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Serine protease 57, ... 著者 Eigenbrot, C, Lin, S.J, Dong, K.C. 登録日 2014-04-25 公開日 2014-09-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structures of neutrophil serine protease 4 reveal an unusual mechanism of substrate recognition by a trypsin-fold protease. Structure, 22, 2014
4QGW	Crystal sturcture of the R132K:R111L:L121D mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.77 angstrom resolution 分子名称: (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cellular retinoic acid-binding protein 2 著者 Nosrati, M, Yapici, I, Geiger, J.H. 登録日 2014-05-26 公開日 2015-01-28 最終更新日 2015-02-11 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 "Turn-on" protein fluorescence: in situ formation of cyanine dyes. J.Am.Chem.Soc., 137, 2015
4PZY	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: 2-chloro-1-(1H-indol-3-yl)ethanone, GUANOSINE-5'-DIPHOSPHATE, K-Ras, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4PZX	Synthesis, Characterization and PK/PD Studies of a Series of Spirocyclic Pyranochromene BACE1 Inhibitors 分子名称: (4R,4a'R,10a'R)-7'-(5-chloropyridin-3-yl)-3',4',4a',10a'-tetrahydro-1'H-spiro[1,3-oxazole-4,5'-pyrano[3,4-b]chromen]-2-amine, Beta-secretase 1, NICKEL (II) ION 著者 Vigers, G.P.A. 登録日 2014-03-31 公開日 2014-05-14 最終更新日 2014-10-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors. Bioorg.Med.Chem.Lett., 24, 2014
4Q1X	Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance 分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ASPARTYL PROTEASE, GLYCEROL, ... 著者 Ragland, D.A, Nalam, M.N.L, Cao, H, Nalivaika, E.A, Cai, Y, Kurt-Yilmaz, N, Schiffer, C.A. 登録日 2014-04-04 公開日 2015-02-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease. J.Am.Chem.Soc., 136, 2014
4Q2K	Bovine alpha chymotrypsin bound to a cyclic peptide inhibitor, 5b 分子名称: (11S)-4,9-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-17,22-dioxa-10,30-diazatetracyclo[21.2.2.2~13,16~.1~5,8~]triaconta-1(25),5,7,13,15,23,26,28-octaene-11-carboxamide, Chymotrypsinogen A 著者 Chan, H.Y, Bruning, J.B, Abell, A.D. 登録日 2014-04-09 公開日 2014-07-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Macrocyclic protease inhibitors with reduced peptide character. Angew.Chem.Int.Ed.Engl., 53, 2014
4Q7K	Structure of NBD287 of TM287/288 分子名称: ABC transporter 著者 Bukowska, M.A, Hohl, M, Gruetter, M.G, Seeger, M.A. 登録日 2014-04-25 公開日 2015-05-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter. Biochemistry, 54, 2015
4Q7L	Structure of NBD288 of TM287/288 分子名称: NICKEL (II) ION, Uncharacterized ABC transporter ATP-binding protein TM_0288 著者 Bukowska, M.A, Hohl, M, Gruetter, M.G, Seeger, M.A. 登録日 2014-04-25 公開日 2015-05-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter. Biochemistry, 54, 2015
4QAU	Crystal structure of F43Y mutant of sperm whale myoglobin 分子名称: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE 著者 Lin, Y, Tan, X, Li, W. 登録日 2014-05-06 公開日 2015-01-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.597 Å) 主引用文献 A Novel Tyrosine-Heme C-O Covalent Linkage in F43Y Myoglobin: A New Post-translational Modification of Heme Proteins Chembiochem, 16, 2015
4PYW	1.92 angstrom crystal structure of A1AT:TTAI ternary complex 分子名称: ACE-THR-THR-ALA-ILE-NH2, Alpha-1-antitrypsin, GLYCEROL 著者 Nyon, M.P, Day, J, Gooptu, B. 登録日 2014-03-28 公開日 2015-06-10 最終更新日 2022-08-24 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of alpha 1 -antitrypsin upon ligand binding. Protein Sci., 24, 2015
4Q01	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: GUANOSINE-5'-DIPHOSPHATE, K-Ras, MAGNESIUM ION, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.291 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4PWN	Crystal structure of Active WNK1 kinase 分子名称: PHOSPHATE ION, Serine/threonine-protein kinase WNK1 著者 Piala, A, Moon, T, Akella, T, He, H, Cobbm, M.H, Goldsmith, E. 登録日 2014-03-20 公開日 2014-05-28 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation. Sci.Signal., 7, 2014
4PYP	Crystal structure of the human glucose transporter GLUT1 分子名称: Solute carrier family 2, facilitated glucose transporter member 1, nonyl beta-D-glucopyranoside 著者 Deng, D, Yan, C.Y, Xu, C, Wu, J.P, Sun, P.C, Hu, M.X, Yan, N. 登録日 2014-03-27 公開日 2014-05-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.166 Å) 主引用文献 Crystal structure of the human glucose transporter GLUT1 Nature, 510, 2014
4PZ5	Crystal structure of the second and third fibronectin F1 modules in complex with a fragment of BBK32 from Borrelia burgdorferi 分子名称: Fibronectin, Fibronectin-binding protein BBK32 著者 Harris, G, Potts, J.R. 登録日 2014-03-28 公開日 2014-07-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Borrelia burgdorferi Protein BBK32 Binds to Soluble Fibronectin via the N-terminal 70-kDa Region, Causing Fibronectin to Undergo Conformational Extension. J.Biol.Chem., 289, 2014
4QFI	The crystal structure of rat angiogenin-heparin complex 分子名称: ACETIC ACID, Angiogenin, ZINC ION 著者 Yeo, K.J, Hwang, E, Min, K.M, Hwang, K.Y, Jeon, Y.H, Chang, S.I, Cheong, H.K. 登録日 2014-05-21 公開日 2014-08-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.784 Å) 主引用文献 The crystal structure of rat angiogenin-heparin complex To be Published
4QJ8	Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (P453L) 分子名称: GLYCEROL, PHOSPHATE ION, Protease, ... 著者 Lin, K.H, Schiffer, C.A. 登録日 2014-06-03 公開日 2014-10-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease. Proc.Natl.Acad.Sci.USA, 111, 2014
4QKI	Dimeric form of human LLT1, a ligand for NKR-P1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-type lectin domain family 2 member D 著者 Skalova, T, Blaha, J, Harlos, K, Duskova, J, Koval, T, Stransky, J, Hasek, J, Vanek, O, Dohnalek, J. 登録日 2014-06-06 公開日 2015-03-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states Acta Crystallogr.,Sect.D, 71, 2015
3KFH	Major mouse urinary protein IV complexed with 2-ethylhexanol 分子名称: (2S)-2-ethylhexan-1-ol, CHLORIDE ION, Major urinary protein 4 著者 Perez-Miller, S, Zou, Q, Hurley, T.D. 登録日 2009-10-27 公開日 2010-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.02 Å) 主引用文献 High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones. Protein Sci., 19, 2010
7BGU	Mason-Pfizer Monkey Virus Protease mutant C7A/D26N/C106A in complex with peptidomimetic inhibitor 分子名称: Gag-Pro-Pol polyprotein, PENTAETHYLENE GLYCOL, peptidomimetic inhibitor 著者 Wosicki, S, Gilski, M, Kazmierczyk, M, Jaskolski, M, Zabranska, H, Pichova, I. 登録日 2021-01-08 公開日 2021-12-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.433 Å) 主引用文献 Crystal structures of inhibitor complexes of M-PMV protease with visible flap loops. Protein Sci., 30, 2021
7BGT	Mason-Pfizer Monkey Virus Protease mutant C7A/D26N/C106A in complex with peptidomimetic inhibitor 分子名称: ACETATE ION, Gag-Pro-Pol polyprotein, PENTAETHYLENE GLYCOL, ... 著者 Wosicki, S, Gilski, M, Jaskolski, M, Zabranska, H, Pichova, I. 登録日 2021-01-08 公開日 2021-12-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Crystal structures of inhibitor complexes of M-PMV protease with visible flap loops. Protein Sci., 30, 2021
3KFR	HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 1F1 in the outside/top of flap 分子名称: 1H-indole-6-carboxylic acid, BETA-MERCAPTOETHANOL, Protease, ... 著者 Stout, C.D. 登録日 2009-10-27 公開日 2010-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Fragment-based screen against HIV protease. Chem.Biol.Drug Des., 75, 2010
2KXL	Solution structure of a bacterial cyclic nucleotide-activated K+ channel binding domain in the unliganded state 分子名称: Cyclic nucleotide-gated potassium channel mll3241 著者 Schunke, S, Stoldt, M, Willbold, D. 登録日 2010-05-10 公開日 2011-04-20 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channel. Proc.Natl.Acad.Sci.USA, 108, 2011
3KDB	Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10006 分子名称: (4R)-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, GLYCEROL, Protease 著者 Chufan, E.E, Lafont, V, Freire, E, Amzel, L.M. 登録日 2009-10-22 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 How much binding affinity can be gained by filling a cavity? Chem.Biol.Drug Des., 75, 2010
2KXH	Solution structure of the first two RRM domains of FIR in the complex with FBP Nbox peptide 分子名称: Poly(U)-binding-splicing factor PUF60, peptide of Far upstream element-binding protein 1 著者 Cukier, C.D, Ramos, A, Hollingworth, D, Diaz-Moreno, I, Kelly, G. 登録日 2010-05-05 公開日 2010-08-18 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Molecular basis of FIR-mediated c-myc transcriptional control. Nat.Struct.Mol.Biol., 17, 2010

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