3KFR

HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 1F1 in the outside/top of flap

Summary for 3KFR

• Entry DOI: 10.2210/pdb3kfr/pdb
• Related: 2AZ8 3KF0 3KF1 3KFN 3KFP 3KFS
• Related PRD ID: PRD_000434
• Descriptor: Protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, BETA-MERCAPTOETHANOL, ... (5 entities in total)
• Functional Keywords: hiv-1, protease, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22890.17

Authors

Stout, C.D. (deposition date: 2009-10-27, release date: 2010-02-23, Last modification date: 2023-09-06)

• Primary citation: Perryman, A.L.,Zhang, Q.,Soutter, H.H.,Rosenfeld, R.,McRee, D.E.,Olson, A.J.,Elder, J.E.,David Stout, C.; Fragment-based screen against HIV protease.; Chem.Biol.Drug Des., 75:257-268, 2010; PubMed: 20659109; DOI: 10.1111/j.1747-0285.2009.00943.x

Experimental method

X-RAY DIFFRACTION (1.3 Å)