4QJ8

Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (P453L)

Summary for 4QJ8

Entry DOI	10.2210/pdb4qj8/pdb
Related	4QJ2 4QJ6 4QJ7 4QJ9 4QJA
Descriptor	Protease, p1-p6 peptide, GLYCEROL, ... (5 entities in total)
Functional Keywords	co-evolution, protease, hydrolase
Biological source	Human immunodeficiency virus type 1 (ARV2/SF2 ISOLATE) (HIV-1) More
Cellular location	Matrix protein p17: Virion . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
Total number of polymer chains	6
Total formula weight	46350.23
Authors	Lin, K.H.,Schiffer, C.A. (deposition date: 2014-06-03, release date: 2014-10-29, Last modification date: 2024-02-28)
Primary citation	Ozen, A.,Lin, K.H.,Kurt Yilmaz, N.,Schiffer, C.A. Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease. Proc.Natl.Acad.Sci.USA, 111:15993-15998, 2014 Cited by PubMed: 25355911 DOI: 10.1073/pnas.1414063111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation