4QJ6
Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (L449F)
Summary for 4QJ6
Entry DOI | 10.2210/pdb4qj6/pdb |
Related | 4QJ6 4QJ7 4QJ8 4QJ9 4QJA |
Descriptor | Protease, p1-p6 peptide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | co-evolution, protease, hydrolase |
Biological source | Human immunodeficiency virus type 1 (ARV2/SF2 ISOLATE) (HIV-1) More |
Cellular location | Matrix protein p17: Virion . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 6 |
Total formula weight | 45922.13 |
Authors | Lin, K.H.,Schiffer, C.A. (deposition date: 2014-06-03, release date: 2014-10-29, Last modification date: 2024-02-28) |
Primary citation | Ozen, A.,Lin, K.H.,Kurt Yilmaz, N.,Schiffer, C.A. Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease. Proc.Natl.Acad.Sci.USA, 111:15993-15998, 2014 Cited by PubMed: 25355911DOI: 10.1073/pnas.1414063111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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