4QJ8
Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (P453L)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Protease | polymer | 99 | 10828.8 | 4 | UniProt (P03369) Pfam (PF00077) | Human immunodeficiency virus type 1 (ARV2/SF2 ISOLATE) (HIV-1) | Retropepsin |
| 2 | E, F (E, F) | p1-p6 peptide | polymer | 10 | 1189.4 | 2 | UniProt (by SIFTS) (P03349) | Human immunodeficiency virus type 1 (ARV2/SF2 ISOLATE) | |
| 3 | G, H, J (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | I, K, L, M (A, C, D) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 5 | N, O, P, Q, R... (A, B, C, D, E...) | water | water | 18.0 | 170 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 497 | engineered mutation |
| Asn 25 | Asp 515 | engineered mutation |
| Val 50 | Ile 540 | engineered mutation |
| Ile 64 | Val 554 | engineered mutation |
| Val 71 | Ala 561 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 45694.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 656.2 | |
| All* | Total formula weight | 46350.2 |
