PDB: 2682 件ウェブページステータス検索Chemie searchBIRD

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3CC9	Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate 分子名称: GERANYLGERANYL DIPHOSPHATE, Putative farnesyl pyrophosphate synthase, SODIUM ION 著者 Wernimont, A.K, Dunford, J, Lew, J, Zhao, Y, Kozieradzki, I, Cossar, D, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC) 登録日 2008-02-25 公開日 2008-03-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate. To be Published
1UZU	Glycogen Phosphorylase b in complex with indirubin-5'-sulphonate 分子名称: 2',3-DIOXO-1,1',2',3-TETRAHYDRO-2,3'-BIINDOLE-5'-SULFONIC ACID, GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, ... 著者 Kosmopoulou, M.N, Leonidas, D.D, Chrysina, E.D, Bischler, N, Eisenbrand, G, Sakarellos, C.E, Pauptit, R, Oikonomakos, N.G. 登録日 2004-03-16 公開日 2004-05-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex. Eur. J. Biochem., 271, 2004
1VQM	The structure of the transition state analogue "DAN" bound to the large ribosomal subunit of haloarcula marismortui 分子名称: 23S ribosomal rna, 5'-R(*CP*CP*(PPU)P*(PO2)P*(DA)P*C*C)-3'), 50S RIBOSOMAL PROTEIN L10E, ... 著者 Schmeing, T.M, Steitz, T.A. 登録日 2004-12-16 公開日 2005-11-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Insights into the Roles of Water and the 2' Hydroxyl of the P Site tRNA in the Peptidyl Transferase Reaction. Mol.Cell, 20, 2005
1VQK	The structure of CCDA-PHE-CAP-BIO bound to the a site of the ribosomal subunit of haloarcula marismortui 分子名称: 23S ribosomal rna, 5'-R(*CP*CP*(DA)*(PHE)*(ACA))-3', 50S RIBOSOMAL PROTEIN L10E, ... 著者 Schmeing, T.M, Steitz, T.A. 登録日 2004-12-16 公開日 2005-11-29 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Insights into the Roles of Water and the 2' Hydroxyl of the P Site tRNA in the Peptidyl Transferase Reaction. Mol.Cell, 20, 2005
3GPB	COMPARISON OF THE BINDING OF GLUCOSE AND GLUCOSE-1-PHOSPHATE DERIVATIVES TO T-STATE GLYCOGEN PHOSPHORYLASE B 分子名称: 1-O-phosphono-alpha-D-glucopyranose, GLYCOGEN PHOSPHORYLASE B, PYRIDOXAL-5'-PHOSPHATE 著者 Martin, J.L, Johnson, L.N. 登録日 1990-06-04 公開日 1992-10-15 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Comparison of the binding of glucose and glucose 1-phosphate derivatives to T-state glycogen phosphorylase b. Biochemistry, 29, 1990
2AMV	THE STRUCTURE OF GLYCOGEN PHOSPHORYLASE B WITH AN ALKYL-DIHYDROPYRIDINE-DICARBOXYLIC ACID 分子名称: 2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM, GLYCEROL, PROTEIN (GLYCOGEN PHOSPHORYLASE), ... 著者 Zographos, S.E, Oikonomakos, N.G, Johnson, L.N. 登録日 1998-10-13 公開日 1998-10-21 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor. Structure, 5, 1997
1VQL	The structure of the transition state analogue "DCSN" bound to the large ribosomal subunit of haloarcula marismortui 分子名称: 23S ribosomal rna, 5'-R(*CP*CP*(PPU)*(TSE)*(DA)*CP*C)-3', 50S RIBOSOMAL PROTEIN L10E, ... 著者 Schmeing, T.M, Steitz, T.A. 登録日 2004-12-16 公開日 2005-11-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Insights into the Roles of Water and the 2' Hydroxyl of the P Site tRNA in the Peptidyl Transferase Reaction. Mol.Cell, 20, 2005
3EZ3	Crystal Structure of Plasmodium vivax geranylgeranylpyrophosphate synthase PVX_092040 with zoledronate and IPP bound 分子名称: 1,2-ETHANEDIOL, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, ... 著者 Wernimont, A.K, Lew, J, Zhao, Y, Kozieradzki, I, Cossar, D, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC) 登録日 2008-10-22 公開日 2008-12-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.304 Å) 主引用文献 Crystal Structure of Plasmodium vivax geranylgeranylpyrophosphate synthase PVX_092040 with zoledronate and IPP bound TO BE PUBLISHED
5AYP	Crystal structure of Bacillus stearothermophilus Farnesyl pyrophosphate synthase 分子名称: Farnesyl diphosphate synthase 著者 Makabe, K, Kijima, T. 登録日 2015-08-26 公開日 2016-09-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Crystal structure of Bacillus stearothermophilus Farnesyl pyrophosphate synthase To Be Published
7KEZ	Crystal structure of bH1 Fab variant (CDR H3 loop design 16_0325) in complex with VEGF 分子名称: CHLORIDE ION, Isoform L-VEGF206 of Vascular endothelial growth factor A, anti-VEGF-A Fab bH1 heavy chain, ... 著者 Shi, R, Manenda, M.S, Picard, M.-E. 登録日 2020-10-13 公開日 2021-11-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Crystal structure of bH1 Fab CDR H3 loop variants in apo form and in complex with VEGF to be published
8G6X	Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site meta-aminobenzoic acid charged NH-tRNAPhe 分子名称: 23S rRNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), 3-aminobenzamide, ... 著者 Majumdar, C, Cate, J.H.D. 登録日 2023-02-16 公開日 2023-03-22 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.31 Å) 主引用文献 Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome. Acs Cent.Sci., 9, 2023
6FJY	Crystal structure of CsuC-CsuE chaperone-tip adhesion subunit pre-assembly complex from archaic chaperone-usher Csu pili of Acinetobacter baumannii 分子名称: CsuC, Protein CsuE 著者 Pakharukova, N.A, Tuitilla, M, Paavilainen, S, Zavialov, A.V. 登録日 2018-01-23 公開日 2018-05-16 最終更新日 2018-09-19 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Structural basis forAcinetobacter baumanniibiofilm formation. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7LL8	D-Protein RFX-V1 Bound to the VEGFR1 Domain 2 Site on VEGF-A 分子名称: Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V1 著者 Marinec, P.S, Landgraf, K.E, Uppalapati, M, Chen, G, Xie, D, Jiang, Q, Zhao, Y, Petriello, A, Deshayes, K, Kent, S.B.H, Ault-Riche, D, Sidhu, S.S. 登録日 2021-02-03 公開日 2021-02-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth. Acs Chem.Biol., 16, 2021
4RXC	T. Brucei Farnesyl Diphosphate Synthase Complexed with Homorisedronate BPH-6 分子名称: Farnesyl pyrophosphate synthase, MAGNESIUM ION, [1-hydroxy-3-(pyridin-3-yl)propane-1,1-diyl]bis(phosphonic acid) 著者 Cao, R, Liu, Y.-L, Oldfield, E. 登録日 2014-12-09 公開日 2015-04-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. ACS Med Chem Lett, 6, 2015
1GG8	DESIGN OF INHIBITORS OF GLYCOGEN PHOSPHORYLASE: A STUDY OF ALPHA-AND BETA-C-GLUCOSIDES AND 1-THIO-BETA-D-GLUCOSE COMPOUNDS 分子名称: ALPHA-D-GLUCOPYRANOSYL-2-CARBOXYLIC ACID AMIDE, INOSINIC ACID, PROTEIN (GLYCOGEN PHOSPHORYLASE), ... 著者 Watson, K.A, Mitchell, E.P, Johnson, L.N, Son, J.C, Bichard, C.J, Orchard, M.G, Fleet, G.W, Oikonomakos, N.G, Leonidas, D.D, Kontou, M, Papageorgiou, A.C. 登録日 2000-07-30 公開日 2000-08-23 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds. Biochemistry, 33, 1994
2E92	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-261 分子名称: (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID), Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION 著者 Guo, R.T, Ko, T.P, Cao, R, Jeng, W.Y, Chen, C.K.-M, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. 登録日 2007-01-24 公開日 2007-06-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
7KF0	Crystal structure of bH1 Fab variant (CDR H3 loop design 13_0346) in complex with VEGF 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Isoform L-VEGF206 of Vascular endothelial growth factor A, ... 著者 Shi, R, Picard, M.-E. 登録日 2020-10-13 公開日 2021-11-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Crystal structure of bH1 Fab CDR H3 loop variants in apo form and in complex with VEGF to be published
8HSP	E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and t6A37 in classical state 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Akiyama, N, Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. 登録日 2022-12-20 公開日 2024-04-03 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.32 Å) 主引用文献 Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine. Nat.Struct.Mol.Biol., 31, 2024
7PZY	Structure of the vacant Candida albicans 80S ribosome 分子名称: 1,4-DIAMINOBUTANE, 18S ribosomal RNA, 25S ribosomal RNA, ... 著者 Zgadzay, Y, Kolosova, O, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M. 登録日 2021-10-13 公開日 2022-05-18 最終更新日 2022-06-08 実験手法 ELECTRON MICROSCOPY (2.32 Å) 主引用文献 E-site drug specificity of the human pathogen Candida albicans ribosome. Sci Adv, 8, 2022
5QT4	T. brucei FPPS in complex with CID 3599333 分子名称: 1-[3-(4-chlorophenoxy)propyl]-1H-imidazole, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... 著者 Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W. 登録日 2019-08-07 公開日 2020-10-07 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.324 Å) 主引用文献 T. brucei FPPS in complex with CID 3599333 To Be Published
6Y5O	The crystal structure of glycogen phosphorylase in complex with 20 分子名称: 2-(4-fluorophenyl)-5,7-bis(oxidanyl)chromen-4-one, Glycogen phosphorylase, muscle form 著者 Kyriakis, E, Koulas, S.M, Skamnaki, V.T, Leonidas, D.D. 登録日 2020-02-25 公開日 2020-08-19 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. Bioorg.Chem., 102, 2020
6SII	T. brucei FPPS in complex with 1-((1H-indol-3-yl)methyl)-N-(3-chlorobenzyl)piperidin-4-amine 分子名称: Farnesyl pyrophosphate synthase, GLYCEROL, ~{N}-[(3-chlorophenyl)methyl]-1-(1~{H}-indol-3-ylmethyl)piperidin-4-amine 著者 Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W. 登録日 2019-08-09 公開日 2020-08-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 T. brucei FPPS To Be Published
8BF7	Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site 分子名称: 16S rRNA RRSB-RRNA, 23S rRNA RRLG-RRNA, 30S ribosomal protein S10, ... 著者 Koziej, L, Glatt, S. 登録日 2022-10-24 公開日 2023-08-16 実験手法 ELECTRON MICROSCOPY (2.33 Å) 主引用文献 Modulation of translational decoding by m 6 A modification of mRNA. Nat Commun, 14, 2023
7N1P	Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation 分子名称: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... 著者 Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, S.K, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. 登録日 2021-05-28 公開日 2021-07-14 最終更新日 2021-08-11 実験手法 ELECTRON MICROSCOPY (2.33 Å) 主引用文献 Structural basis of early translocation events on the ribosome. Nature, 595, 2021
6R38	T. brucei FPPS in complex with 2-(2,5-dichlorobenzo[b]thiophen-3-yl)acetic acid 分子名称: 2-[2,5-bis(chloranyl)-1-benzothiophen-3-yl]ethanoic acid, DIMETHYL SULFOXIDE, Farnesyl pyrophosphate synthase 著者 Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W. 登録日 2019-03-19 公開日 2020-04-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery Thesis, 2019

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