PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

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8AV0	small molecule stabilizer (compound 1) for C-RAF pS259 and 14-3-3 分子名称: 1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2022-08-26 公開日 2023-04-26 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. Acs Cent.Sci., 9, 2023
2B53	Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325 分子名称: 6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE, Cell division protein kinase 2 著者 Muckelbauer, J. 登録日 2005-09-27 公開日 2005-10-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Quinazolines as Cyclin Dependent Kinase Inhibitors Bioorg.Med.Chem.Lett., 11, 2001
2B55	Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312 分子名称: 2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE, Cell division protein kinase 2 著者 Muckelbauer, J. 登録日 2005-09-27 公開日 2005-10-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3 J.Med.Chem., 45, 2002
3LL8	Crystal Structure of Calcineurin in Complex with AKAP79 Peptide 分子名称: AKAP79 peptide, CALCIUM ION, Calcineurin subunit B type 1, ... 著者 Li, H, Hogan, P.G. 登録日 2010-01-28 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Balanced interactions of calcineurin with AKAP79 regulate Ca(2+)-calcineurin-NFAT signaling. Nat.Struct.Mol.Biol., 19, 2012
5KIT	Crystal Structure of Nicotinamide Phosphoribosyltransferase (Nampt) in Complex with Inhibitors 37 分子名称: 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, ... 著者 Li, D, Wang, W. 登録日 2016-06-17 公開日 2016-08-31 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. J.Med.Chem., 59, 2016
1H26	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53 分子名称: CELL DIVISION PROTEIN KINASE 2, CELLULAR TUMOR ANTIGEN P53, CYCLIN A2 著者 Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N. 登録日 2002-07-31 公開日 2003-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A Biochemistry, 41, 2002
3L5W	Crystal structure of the complex between IL-13 and C836 FAB 分子名称: C836 HEAVY CHAIN, C836 LIGHT CHAIN, GLYCEROL, ... 著者 Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L. 登録日 2009-12-22 公開日 2010-04-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Human framework adaptation of a mouse anti-human IL-13 antibody. J.Mol.Biol., 398, 2010
4BG6	14-3-3 interaction with Rnd3 prenyl-phosphorylation motif 分子名称: 14-3-3 PROTEIN ZETA/DELTA, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FARNESYL, ... 著者 Riou, P, Kjaer, S, Purkiss, A, O'Reilly, N, McDonald, N.Q. 登録日 2013-03-23 公開日 2013-05-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins. Cell(Cambridge,Mass.), 153, 2013
7MKX	Crystal Structure Analysis of human CDK2 and CCNA2 complex 分子名称: 2-[(5-bromo-2-{4-[(cyanomethyl)sulfamoyl]anilino}pyrimidin-4-yl)amino]-6-fluorobenzamide, Cyclin-A2, Cyclin-dependent kinase 2 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2021-04-27 公開日 2022-11-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Crystal Structure Analysis of human CDK2 and CCNA2 complex To Be Published
4O0Z	Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase 分子名称: N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}indolizine-6-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION 著者 Oh, A, Wang, W. 登録日 2013-12-14 公開日 2014-06-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.049 Å) 主引用文献 Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem, 15, 2014
8TWA	Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA-PolE-DNA complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18, Chromosome transmission fidelity protein 8, ... 著者 Yuan, Z, Georgescu, R, O'Donnell, M, Li, H. 登録日 2023-08-20 公開日 2024-09-04 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Cryo-EM reveals that Ctf18-RFC collaborates with PolE to load the PCNA clamp onto a leading strand DNA To Be Published
7NFW	Human 14-3-3 sigma in complex with human Estrogen Receptor alpha peptide 分子名称: 14-3-3 protein sigma, Estrogen receptor 著者 Roversi, P, Falcicchio, M, Doveston, R. 登録日 2021-02-08 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Cooperative stabilisation of 14-3-3 sigma protein-protein interactions via covalent protein modification. Chem Sci, 12, 2021
1YO5	Analysis of the 2.0A crystal structure of the protein-DNA complex of human PDEF Ets domain bound to the prostate specific antigen regulatory site 分子名称: Enhancer site of Prostate Specific Antigen Promoter Region, SAM pointed domain containing ets transcription factor 著者 Wang, Y, Feng, L, Said, M, Balderman, S, Fayazi, Z, Liu, Y, Ghosh, D, Gulick, A.M. 登録日 2005-01-26 公開日 2005-05-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Analysis of the 2.0 A Crystal Structure of the Protein-DNA Complex of the Human PDEF Ets Domain Bound to the Prostate Specific Antigen Regulatory Site Biochemistry, 44, 2005
8AV8	Small molecular stabilizer for ERalpha and 14-3-3 (1075300) 分子名称: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-(1-phenoxycyclopentyl)carbonylpiperidin-4-yl]methyl]ethanamide, Estrogen receptor, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-08-26 公開日 2023-09-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
5JI5	Crystal Structure of a Histone Deacetylase superfamily protein from Burkholderia phymatumphymatum 分子名称: 1,2-ETHANEDIOL, BuphA.10154.a.B1, SODIUM ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-04-21 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of a Histone Deacetylase superfamily protein from Burkholderia phymatumphymatum to be published
8ANC	14-3-3 sigma sirtuin-3 phospho-peptide complex 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Weyand, M, Steegborn, C, Debbert, L. 登録日 2022-08-05 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.11 Å) 主引用文献 14-3-3 sigma sirtuin-3 phospho-peptide complex To Be Published
3HOM	Crystal structure of oxidized A66C mutant of Human acidic fibroblast growth factor 分子名称: Acidic fibroblast growth factor, FORMIC ACID, SULFATE ION 著者 Blaber, M, Lee, J. 登録日 2009-06-02 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. J.Mol.Biol., 393, 2009
8ANB	14-3-3 sigma sirtuin-1 phospho-peptide complex 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Weyand, M, Steegborn, C, Debbert, L. 登録日 2022-08-05 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 14-3-3 sigma sirtuin-1 phospho-peptide complex To Be Published
8ANF	Small molecule stabilizer for ERalpha and 14-3-3 (1074359) 分子名称: 14-3-3 protein sigma, 2-chloranyl-N-[3-[1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]piperidin-4-yl]propyl]ethanamide, Estrogen receptor, ... 著者 Konstantinidou, M, Visser, E.J, Vandenboorn, E.M.F, Sheng, C, Jaishankar, P, Overmans, M.J.A.M, Dutta, S, Neitz, J, Renslo, A, Ottmann, C, Brunsveld, L, Arkin, M. 登録日 2022-08-05 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
8AQC	Small molecular stabilizer for ERalpha and 14-3-3 (1080294) 分子名称: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-08-12 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
8ARW	Small molecular stabilizer for ERalpha and 14-3-3 (1076402) 分子名称: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-08-17 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
8ARY	Small molecular stabilizer for ERalpha and 14-3-3 (1080273) 分子名称: 14-3-3 protein sigma, 2-chloranyl-N-[[1-[1-(4-chloranylphenoxy)cyclohexyl]carbonylpiperidin-4-yl]methyl]ethanamide, Estrogen receptor, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-08-17 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
8ATR	Small molecular stabilizer for C-RAF (pS259) and 14-3-3 (1075297) 分子名称: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[1-(4-chloranylphenoxy)cyclopentyl]carbonylpiperidin-4-yl]methyl]ethanamide, CHLORIDE ION, ... 著者 Visser, E.J, Overmans, M.J.A.M, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-08-24 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
8ATS	Small molecular stabilizer for C-RAF (pS259) and 14-3-3 (1075306) 分子名称: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[1-[(4-chlorophenyl)amino]cyclopentyl]carbonylpiperidin-4-yl]methyl]ethanamide, CHLORIDE ION, ... 著者 Visser, E.J, Overmans, M.J.A.M, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-08-24 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
8AUY	Small molecule stabilizer for ERalpha and 14-3-3 (1080298) 分子名称: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-08-26 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023

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