8ANF

Small molecule stabilizer for ERalpha and 14-3-3 (1074359)

Summary for 8ANF

• Entry DOI: 10.2210/pdb8anf/pdb
• Descriptor: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: 14-3-3, eralpha, stabilizer, structural protein, signaling protein-pe complex, signaling protein/pe
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 27644.78

Authors

Konstantinidou, M.,Visser, E.J.,Vandenboorn, E.M.F.,Sheng, C.,Jaishankar, P.,Overmans, M.J.A.M.,Dutta, S.,Neitz, J.,Renslo, A.,Ottmann, C.,Brunsveld, L.,Arkin, M. (deposition date: 2022-08-05, release date: 2023-09-20, Last modification date: 2023-10-04)

• Primary citation: Konstantinidou, M.,Visser, E.J.,Vandenboorn, E.,Chen, S.,Jaishankar, P.,Overmans, M.,Dutta, S.,Neitz, R.J.,Renslo, A.R.,Ottmann, C.,Brunsveld, L.,Arkin, M.R.; Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments.; J.Am.Chem.Soc., 145:20328-20343, 2023; PubMed: 37676236; DOI: 10.1021/jacs.3c05161

Experimental method

X-RAY DIFFRACTION (1.4 Å)